“…Some clinical features and tests help diagnose this disease, including bone marrow (BM) biopsy, high hemoglobin, and hematocrit, abnormal level of serum erythropoietin, leukocytosis, increased LDL, and splenomegaly (4). Different studies reported that the determination of some special mutations can be valuable in the screening and diagnosis of different diseases and treatment of patients (5,6). The co-occurrence of these three mutations has been documented.…”