The research study focused is to determining the effect of employee burnout on employee creativity, affective commitment and turnover intention in the pharmaceutical industry in Nigeria. With the growing global trend and ease of migration ‘Japa’, the level of employee burnout has been on an increase as an aftermath of delivering on the performance demands. The study focused on Maslach Inventory Model which categorised employee burnout into emotional exhaustion, Depersonalisation, and reduced personal accomplishment. A structured questionnaire was used to collect primary data from various pharmaceutical workers in the city of Lagos, Nigeria. A total of one hundred and eighty-four employees were sampled using the convenience sampling technique. The collated data were analysed using regression analysis was used to test the hypotheses. The findings reveal that; there is a significant relationship between employee burnout and employee creativity, there is a significant relationship between employee burnout and affective commitment, and there is a significant influence of employee burnout on turnover intention. The study, however, recommends that to strengthen the organization's burnout-reduction system, the organisation need to encourage various strategic business or functional units to design burnout-reduction programs and initiatives that they believe would be beneficial in their units. In relation to how employee burnout is addressed, the business may also devise a method to award the best unit in terms of creativity, innovation, commitment, and productivity.