The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells

Lehmann, Alan R.; Kirk-Bell, Susan; Shall, Sydney; Whish, William J. D.

doi:10.1016/0014-4827(74)90688-0

Cited by 107 publications

(47 citation statements)

References 39 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…After 30 mm or more at 0°C the precipitated cells were filtered onto glass tibre discs, washed 6 times with 1% trichloroacetic acid, once with acetone and the radioactivity counted. The radioactive trichloroacetic acid-insoluble material was shown to be poly(ADP-ribose) by digestion with snake venom phosphodiesterase and thin layer chromatography of the products [5].…”

Section: Poly(a Dp-ribose) Polymerase Assaymentioning

confidence: 99%

Poly(ADP‐ribose) polymerase activity in nucleotide permeable cells

1978

View full text Add to dashboard Cite

Section: Poly(a Dp-ribose) Polymerase Assaymentioning

confidence: 99%

Poly(ADP‐ribose) polymerase activity in nucleotide permeable cells

1978

View full text Add to dashboard Cite

“…A higher poly(ADP-ribose) polymerase activity in leukemic leukocytes than in lymphocytes from normal donors was observed [6,7]. Similarly, in human and pig lymphocytes, the activity of poly(ADP-ribose) polymerase increased together with DNA synthesis, induced by phytohemagglutinin PHA [7,8]. Finally, an increase in poly(ADP-ribose) polymerase activity in parallel to cellular NAD decrease after treatment of cells with DNA-damaging agents was reported [9,10].…”

Section: Introductionmentioning

confidence: 99%

Effect of nicotinamide on RNA and DNA synthesis and on poly(ADP‐ribose) polymerase activity in normal and phytohemagglutinin stimulated human lymphocytes

et al. 1980

View full text Add to dashboard Cite

“…In addition, PARP activity was found to be enhanced in replicating cells [61], in the vicinity of replication forks [62] and in newly replicated chromatin [63], suggesting that PARPs are an important component of the replication machinery.…”

Section: Parp1 In the Transmission Of Heterochromatin During Cell DIVmentioning

confidence: 99%

The expanding role ofPARPs in the establishment and maintenance of heterochromatin

Dantzer

Santoro

2013

The FEBS Journal

View full text Add to dashboard Cite

Poly(ADP-ribose) polymerases (PARPs) are enzymes that transfer poly (ADP-ribose) (PAR) groups to target proteins, and thereby affect various nuclear and cytoplasmic processes. The activity of PARP family members, such as PARP1 and PARP2, is tied to cellular signalling pathways, and, through poly(ADP-ribosyl)ation, they ultimately promote changes in chromatin architecture, gene expression, and the location and activity of proteins that mediate signalling responses. A growing body of evidence suggest that PARPs, particularly PARP1 and PARP2, also operate at heterochromatic regions such as the inactive X chromosome, telomeres, pericentric heterochromatin and silent ribosomal RNA (rRNA) genes. Both proteins localize to heterochromatic sites and often associate with or poly (ADP-ribosyl)ate histones and heterochromatin-binding proteins, thereby modulating their activities. In this review, we describe current knowledge concerning the role of PARPs in establishment and inheritance of heterochromatic structures, and highlight how their contribution affects biological outcomes.

show abstract

The relationship between cell growth, macromolecular synthesis and poly ADP-ribose polymerase in lymphoid cells

Cited by 107 publications

References 39 publications

Poly(ADP‐ribose) polymerase activity in nucleotide permeable cells

Poly(ADP‐ribose) polymerase activity in nucleotide permeable cells

Effect of nicotinamide on RNA and DNA synthesis and on poly(ADP‐ribose) polymerase activity in normal and phytohemagglutinin stimulated human lymphocytes

The expanding role ofPARPs in the establishment and maintenance of heterochromatin

Contact Info

Product

Resources

About