The relationship between chemerin, bone metabolism, the RANKL/RANK/OPG system, and bone mineral density in girls with anorexia nervosa

Ostrowska, Zofia; Morawiecka-Pietrzak, Małgorzata; Pluskiewicz, Wojciech; Świętochowska, Elżbieta; Strzelczyk, Joanna Katarzyna; Gołąbek, Karolina; Gaździcka, Jadwiga; Ziora, Katarzyna

doi:10.5603/ep.a2021.0103

Cited by 10 publications

(11 citation statements)

References 54 publications

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“…Topical MLT significantly decreased the gingival index and pocket depth as well as serum IL-6 and CRP levels. Apart from its remarkable anti-inflammatory potential, topical MLT also down-regulated salivary RANKL and elevated salivary OPG levels, which is consistent with earlier studies [119][120][121]. The present data implies that RANKL is a key cytokine in bone destruction during periodontitis, and that OPG, as a RANKL decoy receptor, protects against destructive bone disease [122,123].…”

Section: Melatoninsupporting

confidence: 92%

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Lin

Chao

et al. 2022

JCM

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Diabetes mellitus (DM) is a major worldwide health burden. DM is a metabolic disease characterized by chronic hyperglycemia, and if left untreated, can lead to various complications. Individuals with uncontrolled DM are more susceptible to periodontitis due to both a hyper-inflammatory host response and an impaired immune response. Periodontitis, on the other hand, may exacerbate DM by increasing both local and systemic inflammatory components of DM-related complications. The current standard for periodontal treatment in diabetes-associated periodontitis (DP) focuses mostly on reducing bacterial load and less on controlling the excessive host response, and hence, may not be able to resolve DP completely. Over the past decade, natural compounds have emerged as an adjunct approach for modulating the host immune response with the hope of curing DP. The anti-oxidant, anti-inflammatory, and anti-diabetic characteristics of natural substances are well-known, and they can be found in regularly consumed foods and drinks, as well as plants. The pathophysiology of DP and the treatment benefits of various bioactive extracts for DP will be covered in this review.

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Section: Melatoninsupporting

confidence: 92%

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Lin

Chao

et al. 2022

JCM

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“…Osteocalcin and CTX-1 levels were, respectively, >300% and 13% reduced in AN, reflecting a disproportionate suppression of osteoblast function in AN. Because mechanical loading positively contributes to osteoblast differentiation, a ∼30% decrease in the body weight in girls with AN could cause reduced osteocalcin levels ( Ostrowska et al, 2010 ).…”

Section: Clinical Assessment Of Melatonin In Diseases Of Bone Lossmentioning

confidence: 99%

Assessment of the Therapeutic Potential of Melatonin for the Treatment of Osteoporosis Through a Narrative Review of Its Signaling and Preclinical and Clinical Studies

2022

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Melatonin is a bioamine produced primarily in the pineal gland, although peripheral sites, including the gut, may also be its minor source. Melatonin regulates various functions, including circadian rhythm, reproduction, temperature regulation, immune system, cardiovascular system, energy metabolism, and bone metabolism. Studies on cultured bone cells, preclinical disease models of bone loss, and clinical trials suggest favorable modulation of bone metabolism by melatonin. This narrative review gives a comprehensive account of the current understanding of melatonin at the cell/molecular to the systems levels. Melatonin predominantly acts through its cognate receptors, of which melatonin receptor 2 (MT2R) is expressed in mesenchymal stem cells (MSCs), osteoblasts (bone-forming), and osteoclasts (bone-resorbing). Melatonin favors the osteoblastic fate of MSCs, stimulates osteoblast survival and differentiation, and inhibits osteoclastogenic differentiation of hematopoietic stem cells. Produced from osteoblastic cells, osteoprotegerin (OPG) and receptor activator of nuclear factor kappa B ligand (RANKL) critically regulate osteoclastogenesis and melatonin by suppressing the osteoclastogenic RANKL, and upregulating the anti-osteoclastogenic OPG exerts a strong anti-resorptive effect. Although the anti-inflammatory role of melatonin favors osteogenic function and antagonizes the osteoclastogenic function with the participation of SIRT signaling, various miRNAs also mediate the effects of the hormone on bone cells. In rodent models of osteoporosis, melatonin has been unequivocally shown to have an anti-osteoporotic effect. Several clinical trials indicate the bone mass conserving effect of melatonin in aging/postmenopausal osteoporosis. This review aims to determine the possibility of melatonin as a novel class of anti-osteoporosis therapy through the critical assessment of the available literature.

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“…Khalmuratova et al have stated the promoting effects of IL‐17 on bone remodeling in CRS (Khalmuratova et al, 2019). Interestingly, there is considerable literature revealing the effects of Chemerin on bone metabolism and remodeling (Han et al, 2021; Li et al, 2021; Ostrowska et al, 2022). However, little is studied on the effect of Chemerin on CRS bone remodeling.…”

Section: Introductionmentioning

confidence: 99%

Chemerin and IL‐17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis

Xie,

Bai,

Zhou

et al. 2023

Chem Biol Drug Des

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Chronic rhinosinusitis (CRS) is an inflammatory disease of paranasal sinuses. This study is formulated to explore the roles of pro‐inflammatory factors Chemerin and interleukin‐17 (IL‐17) in CRS. Patients suffering from CRS without/with nasal polyps (CRSsNP/CRSwNP), along with volunteers, were recruited. CRS rabbit models were constructed by Staphylococcus aureus infection and rabbits were injected with lentiviral vectors of short hairpin RNA‐targeting Chemerin (shChemerin), followed by micro‐computed tomography (CT) scan. Levels of Chemerin and IL‐17 were determined, and histopathological lesions were observed in subjects and CRS rabbits. Correlations between Chemerin/IL‐17 level and Lund‐Mackay/Lund‐Kennedy scores of subjects and the predictive value of Chemerin or IL‐17 for CRS were analyzed. In CRS patients and rabbits, inflammatory degrees and the level of Chemerin/IL‐17 were increased in pathological tissues or plasma, while Chemerin silencing alleviated CRS symptoms of CRS rabbits. Chemerin and IL‐17 were mainly located in the immune cells of pathological tissues and presented the positive correlation with Lund‐Mackay/Lund‐Kennedy score of CRS patients. Also, they showed high predictive value for CRS. Micro‐CT scan uncovered that CRS rabbits had increased bone remodeling, which was alleviated by Chemerin silencing. Collectively, Chemerin and IL‐17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis.

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The relationship between chemerin, bone metabolism, the RANKL/RANK/OPG system, and bone mineral density in girls with anorexia nervosa

Cited by 10 publications

References 54 publications

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Potential Therapeutic Applications of Natural Compounds in Diabetes-Associated Periodontitis

Assessment of the Therapeutic Potential of Melatonin for the Treatment of Osteoporosis Through a Narrative Review of Its Signaling and Preclinical and Clinical Studies

Chemerin and IL‐17 are potential predictors and Chemerin silencing alleviates inflammatory response and bone remodeling in chronic rhinosinusitis

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