The Relationship Between Cholecystitis and Presence of Helicobacter pylori in the Gallbladder

Motie, Mohammadreza; Rezapanah, Alireza; Abbasi, Hadi; Memar, Bahram; Arianpoor, Arash

doi:10.5812/zjrms.9621

Cited by 4 publications

(3 citation statements)

References 24 publications

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“…A total of 84 studied patients with mean age of 45.19±1.78, 27 were male (32.1%) and 57 were female (67.9%). 23 Findings of the present study were comparable with the other studies. In present study all the patients had abdomen pain and the duration of pain was one to two months in 25.71% and 11.43% had pain for six months.…”

Section: Discussionsupporting

confidence: 92%

A study of H. pylori infection as risk factor for the gall stone disease

et al. 2023

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Background: Gallstones are one of the widely occurring digestive/hepatobiliary disorders. Chronic cholecystitis, cholelithiasis or symptomatic gallbladder is a prolonged mechanical or functional disorder of abnormal gallbladder emptying. Nearly eighty percent of the gallstones are cholesterol gallstones, and 20% are pigmented stones consisting of bilirubin and calcium, the two components present in the bile. The diagnosis is established by a variety of diagnostic tools like ultrasonography, CT scan, ERCP, liver function tests and pancreatic enzyme studies. The hypothesis of the presence of H. pylori in the biliary epithelium of the patients with hepatobiliary ailments has been sporadically investigated. Helicobacter pylori (H. pylori) is a spiral, microaerophilic, gram-negative bacterium. There are many suggestive evidences that the DNA components of H. pylori is found in the bile, gallbladder tissue and/or cholesterol gallstones. The association of gallstones with Helicobacter pylori has been investigated by many authors, but not clearly established. Methods: The present study is aimed to identify the Helicobacter pylori infection as a risk factor for gallstone disease. The histopathological samples of gall bladder mucosa were examined by staining with modified giemsa stain, haematoxylin, and eosin. Results: Our study showed the presence of H. pylori in only one case which is not statistically significant. Moreover, the present study was based on H and E stains only and they should have been substantiated with immunohistochemistry and PCR studies. Thus, further studies are required to establish a causal relationship between the Helicobactor pylori infection and gallstone formation. Conclusions: Helicobacter pylori as a risk factor for gallstones is yet to be proven.

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Section: Discussionsupporting

confidence: 92%

A study of H. pylori infection as risk factor for the gall stone disease

et al. 2023

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“…In addition, similar results have been suggested in Japan, China, Saudi Arabia and Pakistan populations (9)(10)(11)(12). In many studies, the presence of HP in the GB was determined and its correlation with cholecystitis and cholelithiasis was shown (12)(13)(14). In our study, the correlation between the presence of cholelithiasis and HP was clearly seen.…”

Section: Discussionsupporting

confidence: 65%

Helicobacter pylori relationship in cases of coexistence of gastritis and gallbladder disease

UÇAK,

TON ERYİLMAZ,

DİLBAZ

et al. 2023

Acibadem Univ Saglik Bilim Derg

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Purpose: We aimed to investigate the effect of Helicobacter Pylorii (HP) on the development of gallbladder diseases and cholelithiasis and its relationship with gastritis. Methods: 282 gastritis cases with follow-up and operated gallbladder material were included in the study. All histomorphological findings, presence of HP and other variables were compared. Active inflammation and presence of HP were examined in the gastritis group. The gallbladder (GB) disease group was evaluated in terms of cholelithiasis, inflammation, cholesterolosis, intestinal and pyloric metaplasia, and the presence of HP. Results: Gallbladder HP (+) was higher in female patients than in male patients. The presence of HP in the GB was significantly higher in patients with cholelithiasis than patients without cholelithiasis. The incidence of HP in the GB was higher in patients with active gastritis than in patients with inactive gastritis. The presence of HP in the GB was found to be higher in patients with HP on gastric biopsy. HP was found to be less in cases without cholesterolosis in the GB (p

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“…16 Similarly in another study, similar results were found. 26 It is still not known how these bacteria find their way into the gall bladder, but most probable theory is that it travels from stomach to duodenum and through sphincter of Odi enters the biliary system and resides in gall bladder.…”

Section: Discussionmentioning

confidence: 99%

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

Jimdc¹,

Mushtaq²

2019

JIMDC

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Background: Since H pylori has been mostly associated with gastritis its presence in other parts of gastrointestinal system has not been studied much. Few previous studies have identified “H pylori” in gallbladder and found its association in causing cholecystitis and gallstones but only a few studies have been performed in Pakistan that have shown a significant association. Therefore, in this study we looked for the presence of this microorganism in cholecystitis patients and its association with the morphological changes seen in gall bladders. Material and method: All patients with acute and chronic cholecystitis admitted in ANTH between the ages of 18 and 75 years from January 2017 till March 2019, who underwent cholecystectomy, were included in the study. Gall bladder specimens after surgery were sent to Pathology department ANTH and specimens were analyzed for the presence of H pylori bacteria using H&E and Giemsa staining. Signs of inflammation, any hyperplasia, metaplasia, mucosal atrophy or erosion, lymphoid infiltration, fibrosis, cholesterolosis or any other morphological changes were also noted. Association of H.pylori with cholecystitis and other morphological changes were checked by Chi Square analysis. P. value less than 0.05 was considered statistically significant Results: Chronic cholecystitis was present in 91% cases and acute cholecystitis in 9%. Other histological findings were Hyperplasia (10%), Metaplasia (15%), Fibrosis (79%), Cholesterolosis (19%) and ulcerations (36%). H pylori was found in 17% of gall bladders and all the cases were of chronic cholecystitis. Among these, there were 11.7% Males and 88% Females. Gallstones were present in 76.4% cases and age group involvement was seen more among 41-60 years (64.7%). Other histological findings seen in hpylori positive cases were; Hyperplasia in 11.7% cases, Metaplasia in 17.6%, Fibrosis in 94.1%, cholesterolosis in 23.5% and ulcerations in 17.6% cases. Association of H-Pylori with gender, cholecystitis, gall stones, histological features and age distribution was non-significant. Conclusion: Although H pylori infection has been found in cases of chronic cholecystitis and gall stone formation, its association with cholecystitis and other morphological changes could not be proved. Hence, it is uncertain whether H pylori eradication in patients with gastritis can prevent cholecystitis or gall stones formation

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The Relationship Between Cholecystitis and Presence of Helicobacter pylori in the Gallbladder

Cited by 4 publications

References 24 publications

A study of H. pylori infection as risk factor for the gall stone disease

A study of H. pylori infection as risk factor for the gall stone disease

Helicobacter pylori relationship in cases of coexistence of gastritis and gallbladder disease

Association of Clinicopathological features of cholecystitis with H.pylori infection in Gall bladders

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