The objective of the present study was to investigate the effectiveness of schema therapy on marital exhaustion, sexual self-efficacy and women's feeling of loneliness in the family. Based on the objective of the applied type and the method used in this research, the current research was semi-experimental with a pre-test-post-test design with a control group, and the subjects were randomly replaced in the two groups of the experimental and control groups. The statistical population of this research was made up of couples from Sari city who had visited counseling centers in Sari city. A number of 30 people from the statistical population were selected by random cluster sampling in counseling centers of Sari city from October 1400 to August 1401 based on the determined criteria. To collect information, sexual self-efficacy scale (Waziri and Lotfi Kashani, 2012), loneliness scale(Russell Veppello and Catrona, 1980) and marital burnout questionnaire (Pennis, 2003) were used. In the current research, descriptive statistics (mean and standard deviation) and inferential statistics (covariance analysis) were used. The results of the research showed that the coefficients related to the effect of schema therapy on marital exhaustion, sexual self-efficacy and women's feeling of loneliness in the family are significant at the alpha level of 0.05 (p < 0.50). Therefore, the hypothesis of the research based on the effectiveness of schema therapy on marital burnout, sexual self-efficacy and women's feeling of loneliness in the family was confirmed. Based on the obtained results, the schema therapy approach can be used as an effective treatment in reducing marital exhaustion, increasing sexual self-efficacy, and also reducing the feeling of loneliness in women in the family.