The Relationship between Compound Danshen Dripping Pills with Isosorbide Mononitrate in the Treatment of Elderly Patients with Unstable Angina Pectoris

Abstract

Objective To evaluate the clinical efficacy and safety of Compound Danshen Dripping Pill (CDDP) and Isosorbide Mononitrate (ISMN) in the treatment of unstable angina pectoris (UAP) in the elderly. Materials and Methods CNKI, Wanfang, VIP, CBM, and PubMed databases were searched for appropriate articles without language limitations on keywords. RevMan 5.3 software was used to perform the meta-analysis. Results This analysis compared CDDP with ISMN of 21 randomized controlled trials (RCTs) that involved a total of 2356 patients with UAP. When the treatment lasted for four weeks, the clinical effective rate was OR = 3.97, 95% CI = 2.97, 5.30, and P < 0.00001, the ECG efficiency was OR = 3.43, 95% CI = 2.13, 5.53, and P < 0.00001, and incidence of adverse reactions was OR = 0.73, 95% CI = 0.52, 1.04, and P = 0.08 > 0.05. When the treatment lasted for eight weeks, clinical efficiency rate was OR = 4.22, 95% CI = 2.37, 3.79, and P < 0.00001, incidence of adverse reactions was OR = 0.58, 95% CI = 0.26, 1.27, and P = 0.17 > 0.05, whole blood low-cut blood viscosity was SMD = -0.61 and 95% CI -1.60, 0.38, whole blood high-cut blood viscosity was SMD = -0.38 and 95% CI -0.97, 0.21, and blood cells specific volume was SMD = -0.80 and 95% CI -2.61, 1.01. Conclusion Based on this meta-analysis, the CDDP was superior to ISMN with UAP in the elderly. However, there is still a need to further verify the clinical efficacy and safety of CDDP with more strictly designed RCTs with large sample and multiple centers in the future.

Study of Scraping with Copper Stone Based on Theory of Midnight-Noon Ebb-Flow in Angina Pectoris with Coronary Heart Disease of Qi Stagnation and Blood Stasis

“…Factors such as overwork, mood disorders, and climate change are potential triggers for the development of the disease, and if not treated in a timely manner, there is a high risk of developing acute myocardial infarction which may lead to a significant increase in the risk of death [ 10 , 11 ]. Pharmacological treatment is a conventional therapy in Western medicine, which mainly focuses on 3 aspects: dilating diseased blood vessels, improving atherosclerosis, and lowering blood pressure, with the purpose of reducing myocardial oxygen consumption, delaying atherosclerotic lesions, improving myocardial blood supply, and thus relieving angina symptoms and reducing mortality [ 12 ]. AP of CHD is called “thoracic obstruction” in TCM theory, and the mechanism of the disease is paralysis of the heart arteries due to poor blood flow, so TCM doctors mostly use the method of activating blood and removing blood stasis for treatment.…”

Compound Danshen Dripping Pill inhibits high altitude-induced hypoxic damage by suppressing oxidative stress and inflammatory responses

“…Numerous studies have demonstrated the therapeutic properties of CDDP through promoting blood circulation, reducing blood viscosity, inhibiting leukocyte adhesion and inflammation, protecting endothelial cells and optimizing myocardial energy metabolism to ameliorate angina symptoms caused by myocardial ischaemia (hypoxia) (Liang et al. 2018 ; Yao et al. 2019 ).…”

Hydroxysafflor Yellow A Ameliorates Myocardial Ischemia/Reperfusion Injury by Suppressing Calcium Overload and Apoptosis

“…Our research is not limited to MIRI treatment, and preadminis-tration also means that the candidate is potential to have a preventive effect for coronary heart disease. For example, such as the marketed compound Danshen tablets, compound Danshen dripping pills, and Tongxinluo capsules can prevent and treat coronary heart disease and be helpful for patients at risk of cardiovascular disease [43][44][45]. In fact, in the field of basic research, preadministration of the myocardial ischemia model is a common and recognized method [46,47].…”