2022
DOI: 10.1177/11795549221120158
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The Relationship Between D-dimer and Prognosis in the Patients with Serum Alpha-Fetoprotein-Positive Gastric Cancer: A Retrospective Cohort Study

Abstract: Background: Alpha-fetoprotein-positive gastric cancer (AFPGC) is a subtype of gastric cancer that is rare in clinical practice and extremely malignant. Malignant tumors are often associated with hemorrhage, thrombosis, and even disseminated intravascular coagulation (DIC). The D-dimer test is used as a sensitive index in the diagnosis of DIC and fresh thrombosis in malignant tumors. Therefore, this study aims to investigate the relationship between D-dimer values and the clinical characteristics and prognosis … Show more

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“…Compared with non-AFP-producing gastric cancer, AFPGC exhibits enhanced proliferative capacity, reduced apoptotic rate, and increased neovascularization ability ( 2 ). It is also prone to lymph node metastasis, with 33%–72% of cases developing liver metastasis ( 10 ). Most diagnoses occur at the advanced stage with a poor prognosis.…”
Section: Discussionmentioning
confidence: 99%
“…Compared with non-AFP-producing gastric cancer, AFPGC exhibits enhanced proliferative capacity, reduced apoptotic rate, and increased neovascularization ability ( 2 ). It is also prone to lymph node metastasis, with 33%–72% of cases developing liver metastasis ( 10 ). Most diagnoses occur at the advanced stage with a poor prognosis.…”
Section: Discussionmentioning
confidence: 99%