The Relationship Between Dietary Choices and Health and Premature Vascular Ageing

Mozoş, Ioana; Jianu, Dragoş Cătălin; Stoian, Dana; Mozos, Costin; Gug, Cristina; Pricop, Marius; Mărginean, Otilia; Luca, Constantin

doi:10.1016/j.hlc.2021.07.009

Cited by 12 publications

(7 citation statements)

References 121 publications

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“…PUFAs function not only by activating GPR40 and GPR120, but possess also effects on PPARs and other nuclear receptors [ 100 ]. Recent evidence suggests a maternal diet rich in PUFAs in pregnancy may reduce the child’s aortic stiffness, with potential benefits of prevention for later CVD [ 101 , 102 ]. As PUFAs have been used as dietary supplements with various health claims, there is a growing need to better realize the lipid sensing signals of action of PUFAs, and to be able to explore mechanisms underlying hypertension.…”

Section: The Link Between Nutrient-sensing Signals Disturbed Metaboli...mentioning

confidence: 99%

“…Among them, amino acids are the most commonly used nutrients for prevention of programmed hypertension. Vasoactive properties of dietary proteins depend on the amino acid compositions [ 102 ], which can regulate BP homeostasis. For example, serine, taurine, alanine, and glycine produce depressor responses, while proline, glutamate, aspartic acid, and asparagine yield pressor responses in conscious rats [ 131 ].…”

Section: Reprogramming Strategymentioning

confidence: 99%

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The Impact of Nutrient Intake and Metabolic Wastes during Pregnancy on Offspring Hypertension: Challenges and Future Opportunities

Tain

Hsu

2023

Metabolites

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Hypertension can have its origin in early life. During pregnancy, many metabolic alterations occur in the mother that have a crucial role in fetal development. In response to maternal insults, fetal programming may occur after metabolic disturbance, resulting in programmed hypertension later in life. Maternal dietary nutrients act as metabolic substrates for various metabolic processes via nutrient-sensing signals. Different nutrient-sensing pathways that detect levels of sugars, amino acids, lipids and energy are integrated during pregnancy, while disturbed nutrient-sensing signals have a role in the developmental programming of hypertension. Metabolism-modulated metabolites and nutrient-sensing signals are promising targets for new drug discovery due to their pathogenic link to hypertension programming. Hence, in this review, we pay particular attention to the maternal nutritional insults and metabolic wastes affecting fetal programming. We then discuss the role of nutrient-sensing signals linking the disturbed metabolism to hypertension programming. This review also summarizes current evidence to give directions for future studies regarding how to prevent hypertension via reprogramming strategies, such as nutritional intervention, targeting nutrient-sensing signals, and reduction of metabolic wastes. Better prevention for hypertension may be possible with the help of novel early-life interventions that target altered metabolism.

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Section: The Link Between Nutrient-sensing Signals Disturbed Metaboli...mentioning

confidence: 99%

Section: Reprogramming Strategymentioning

confidence: 99%

The Impact of Nutrient Intake and Metabolic Wastes during Pregnancy on Offspring Hypertension: Challenges and Future Opportunities

Tain

Hsu

2023

Metabolites

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“…Lifestyle modification may have a considerable impact. A diet rich in fruits and vegetables, polyunsaturated fatty acids, coca flavonoids, tea catechins and dairy products with a limited intake of salt and red meat have all been demonstrated to reduce arterial stiffness [36]. Anti-hypertensive treatment, anti-diabetic drugs and lipid lowering agents have also been shown to reverse vascular aging in middle aged individuals, and to a lesser degree, in older patients [37].…”

Section: Future Directionsmentioning

confidence: 99%

Perspective Chapter: Evolution of Techniques to Assess Vascular Impedance in Patients with Aortic Stenosis

Hungerford¹,

Nayya²,

Hansen³

et al. 2022

Aortic Stenosis - Recent Advances, New Perspectives and Applications

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Aortic stenosis (AS) once was conceptualized as a mechanical problem with a fixed left ventricular (LV) afterload because of an obstructive valve. With time, there has been growing recognition that AS functions more like a series circuit, with important contributions from the ventricle through to the vasculature. Emerging evidence suggests that higher blood pressure and increased arterial stiffness, synonymous with vascular aging, increases global LV afterload in patients with AS. This in turn, has adverse consequences on quality-of-life measures and survival. Although traditional methods have emphasized measurement of the transvalvular pressure gradient, focusing on valvular hemodynamics alone may be inadequate. By definition, total vascular load of the human circulation includes both steady and pulsatile components. Steady load is best represented by the systemic vascular resistance whereas pulsatile load occurs because of wave reflections and vascular stiffness, and is often referred to as the valvulo-arterial impedance. In the following Review, we evaluate existing and upcoming methods to assess vascular load in patients with AS in order to better understand the effects of vascular aging on this insidious disease process.

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“…Arterial stiffness increases with age due to atherosclerosis, arteriosclerosis, and calcifications of the vessel. Vascular calcifications, resulting from nucleation of calcium and phosphate into crystals, is associated with a transformation of vascular smooth muscle cells into osteoblast-like cells [ 1 ]. Polyunsaturated fatty acids (PUFA) are recommended by the guidelines of the European Society of Cardiology to reduce blood pressure, low density lipoprotein (LDL) cholesterol, the synthesis of proinflammatory mediators, and to increase the availability of nitric oxide in the vascular wall [ 1 , 2 ].…”

Section: Introductionmentioning

confidence: 99%

“…Vascular calcifications, resulting from nucleation of calcium and phosphate into crystals, is associated with a transformation of vascular smooth muscle cells into osteoblast-like cells [ 1 ]. Polyunsaturated fatty acids (PUFA) are recommended by the guidelines of the European Society of Cardiology to reduce blood pressure, low density lipoprotein (LDL) cholesterol, the synthesis of proinflammatory mediators, and to increase the availability of nitric oxide in the vascular wall [ 1 , 2 ]. Prevalent vegetable oil users, especially extra-virgin olive oil and corn oil, had lower arterial stiffness compared to prevalent animal fat users in a study [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Fatty Acid Levels and Their Inflammatory Metabolites Are Associated with the Nondipping Status and Risk of Obstructive Sleep Apnea Syndrome in Stroke Patients

et al. 2022

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Background: This paper discusses the role of inflammation in the pathogenesis of nondipping blood pressure and its role in the pathogenesis of obstructive sleep apnea syndrome. The aim of the study was to assess the impact of free fatty acids (FAs) and their inflammatory metabolites on the nondipping phenomenon and the risk of sleep apnea in stroke patients. Methods: Sixty-four ischemic stroke patients were included in the prospective study. Group I consisted of 33 patients with a preserved physiological dipping effect (DIP), while group II included 31 patients with the nondipping phenomenon (NDIP). All subjects had FA gas chromatography and inflammatory metabolite measurements performed with the use of liquid chromatography, their 24 h blood pressure was recorded, and they were assessed with the Epworth sleepiness scale (ESS). Results: In the nondipping group a higher level of C16:0 palmitic acid was observed, while lower levels were observed in regard to C20:0 arachidic acid, C22:0 behenic acid and C24:1 nervonic acid. A decreased leukotriene B4 level was recorded in the nondipping group. None of the FAs and derivatives correlated with the ESS scale in the group of patients after stroke. Correlations were observed after dividing into the DIP and NDIP groups. In the DIP group, a higher score of ESS was correlated with numerous FAs and derivatives. Inflammation of a lower degree and a higher level of anti-inflammatory mediators from EPA and DHA acids favored the occurrence of the DIP. A high level of C18: 3n6 gamma linoleic acid indicating advanced inflammation, intensified the NDIP effect. Conclusions: We demonstrated potential novel associations between the FA levels and eicosanoids in the pathogenesis of the nondipping phenomenon. There are common connections between fatty acids, their metabolites, inflammation, obstructive sleep apnea syndrome and nondipping in stroke patients.

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The Relationship Between Dietary Choices and Health and Premature Vascular Ageing

Cited by 12 publications

References 121 publications

The Impact of Nutrient Intake and Metabolic Wastes during Pregnancy on Offspring Hypertension: Challenges and Future Opportunities

The Impact of Nutrient Intake and Metabolic Wastes during Pregnancy on Offspring Hypertension: Challenges and Future Opportunities

Perspective Chapter: Evolution of Techniques to Assess Vascular Impedance in Patients with Aortic Stenosis

Fatty Acid Levels and Their Inflammatory Metabolites Are Associated with the Nondipping Status and Risk of Obstructive Sleep Apnea Syndrome in Stroke Patients

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