The relationship between enthesitis indices and disease activity parameters in patients with ankylosing spondylitis

Abstract

In this study, patients with ankylosing spondylitis (AS) were assessed both by patient and physician using two enthesitis indices and the relationship between these indices and disease activity parameters was investigated. The study involved 100 AS patients. The patients were evaluated with 10-cm visual analog scale (VAS) for spinal pain (VAS-S), peripheral joint pain (VAS-P), global assessment of patient, and global assessment of doctor. In the laboratory evaluations, the erythrocyte sedimentation rates (ESR) and serum C-reactive protein levels of the patients were determined. Bath AS disease activity index (BASDAI), Bath AS functional index (BASFI), Bath AS metrology index, and Bath AS radiology index were calculated. The severity of enthesitis was evaluated according to Mander enthesitis index (MEI) and Maastricht ankylosing spondylitis enthesitis score applied by both the patient (MASES-P) him/herself and the physician (MASES-D). There was a correlation between BASDAI and BASFI as well as MEI, MASES-D, and MASES-P indices (r = 0.447, r = 0.342, r = 0.663, r = 0.530, r = 0.464, and r = 0.435, respectively). No correlation between the laboratory parameters and enthesitis indices were detected. In multiple linear regression analysis, BASFI, VAS-S, and female gender (41.3%) were the best predictors of MEI-D, whereas BASFI, VAS-S, female gender, and ESR (32.5%) were the best predictors for MASES-D and BASFI (18.9%) was the best predictor of MASES-P. The assessment of simple and easily applicable MASES score by a patient may be expected to help the physician in clinical practice. When the disease activity of the patients with AS are evaluated, both BASDAI, the clinical importance of which has been confirmed in numerous studies and which is recommended by ASAS, and BASFI, which is valued by patients, should be considered.

Enthesitis and its relationships with disease parameters in Moroccan patients with ankylosing spondylitis

“…The relationship between disease activity and enthesitis has been reported by several studies; this concord with our results [14,16,17]. Indeed, the relation between BASDAI and enthesitis indexes is probably due to the question related to enthesopathy which BASDAI covers.…”

Gdf5 progenitors give rise to fibrocartilage cells that mineralize via hedgehog signaling to form the zonal enthesis

“…2009). In addition, inflammatory conditions such as spondyloarthropathies, including ankylosing spondylitis (Sivas, et al 2009) and psoriatic arthritis (Mcgonagle. 2005), are localized to the enthesis (Sherlock, et al 2012).…”

The Impacts of Helicobacter Pylori Antigen Positivity on Ankylosing Spondylitis

“…This discrepancy may be due to different associations between diseases and CRP as well as various treatment methods of patients. Several parameters had been investigated whether they have impacts on disease activity of AS or not in order to find out an objective laboratory marker in evaluating disease activity of AS [1,[4][5][6]. For the same purpose, we have used linear regression analysis to clarify the parameters affecting BASDAI, the disease activity index of AS, and we did not find any contributions of the parameters on BASDAI score in this study.…”

“…Introduction Ankylosing spondylitis (AS) is a chronic inflammatory systemic disease of unknown origin which affects the axial skeleton and peripheral joints [1]. Genetic tendency and a number of infectious agents such as Klebsiella pneumonia are the main subjects which are accused in the pathogenesis of AS [2,3].…”