The relationship between gastric emptying of semisolids and paracetamol absorption.

Abstract

The relationship between gastric emptying rate of semisolid Tc‐99m labelled Chelex‐100 resin/oatmeal and paracetamol absorption was determined simultaneously in seven healthy volunteers. There was no significant correlation between the half‐time of gastric emptying and the time of the peak serum paracetamol concentration. There was no significant correlation between the area under the serum paracetamol concentrations at 60 and 90 min and the % meal emptied in 60 and 90 min respectively. Three subjects showed a lag phase in gastric emptying pattern, while the other four showed the emptying curves without evidence of a delayed phase of emptying. Individual values of gastric emptying determined by the methods varied widely.

Inter‐ and intrasubject variability of gastric emptying in healthy volunteers measured by scintigraphy and paracetamol absorption.

“…There is disagreement as to the existence of such a lag period (Christian etal., 1983;Collins etal., 1988). In the present study the emptying pattern of semisolid and the filling curve of the intestine confirmed the existence of a lag period with a significant intersubject variation in its extent (Petring, 1989). Intrasubject variation in the lag period was, however, not significant.…”

“…tion of gastric emptying of either In an attempt to minimize the need for correcsolids is accompanied by significant tion for tissue attenuation we have used a small intrasubject variation (Brophy et (Petring et al, 1986) and the lag period ly could be explained by use of a small was determined by generation of time-activity test meal of approximately 115 ml curves over the intestine. As a result, the lag ( period could be measured even when only anterior detection was used.…”

“…In healthy volunteers no relationship was found between paracetamol absorption and scintigraphic measurement of gastric emptying of semisolids (Petring et al, 1986).…”

“…After an overnight fast for a minimum of 8 hours the volunteers sat while eating a semisolid meal comprising 30 g oatmeal, 5 g sugar, 100 ml of cold milk and paracetamol powder 20 mg kg-1 uniformly mixed with 37 MBq of Tc99m Chelex-100 resin (Petring et al, 1986). To control the extent of mastication, the subjects had to eat the semisolid meal within 10 min.…”

“…Investigations of the effect of gender on gastric emptying have given conflicting results (Datz et al, 1987;Horowitz et al, 1984) and in many studies the possible influence of gender or menstrual cycle on gastric emptying is not considered. In previous studies of gastric emptying in both sexes we observed large differences in emptying rates of a Tc-99m labelled semisolid meal within and between subjects on separate study days (Petring et al, 1986;Petring, 1989).…”