The relationship between gut and adipose hormones, and reproduction

Comninos, Alexander; Jayasena, Channa N.; Dhillo, Waljit S.

doi:10.1093/humupd/dmt033

Cited by 130 publications

(111 citation statements)

References 290 publications

(307 reference statements)

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“…Poor body condition can also reduce the amount of substrate that a female can mobilize from her body to synthesize milk (Berry et al, 2007) and/or reduce the condition of skeletal muscle and other organs that are necessary to capture prey for dependent young (Bachman, 1993). Physiological indicators of body condition, such as the levels of the adipose and gastrointestinal hormones leptin and ghrelin, appear to play an important role in permitting or inhibiting ovulation (Comninos et al, 2014), and thus could reduce future reproductive fitness. Finally, both correlational and experimental studies have shown that reproduction can reduce immune function, which is predicted to reduce the probability of survival (Cichońet al, 2001;Kortet et al, 2003;Lozano and Lank, 2003;Ardia, 2005).…”

Section: Loss Of Somatic Storesmentioning

confidence: 99%

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms

Zhang

Hood

2016

Journal of Experimental Biology

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Oxidative damage is predicted to be a mediator of trade-offs between current reproduction and future reproduction or survival, but most studies fail to support such predictions. We suggest that two factors underlie the equivocal nature of these findings: (1) investigators typically assume a negative linear relationship between current reproduction and future reproduction or survival, even though this is not consistently shown by empirical studies; and (2) studies often fail to target mechanisms that could link interactions between sequential lifehistory events. Here, we review common patterns of reproduction, focusing on the relationships between reproductive performance, survival and parity in females. Observations in a range of species show that performance between sequential reproductive events can decline, remain consistent or increase. We describe likely bioenergetic consequences of reproduction that could underlie these changes in fitness, including mechanisms that could be responsible for negative effects being ephemeral, persistent or delayed. Finally, we make recommendations for designing future studies. We encourage investigators to carefully consider additional or alternative measures of bioenergetic function in studies of life-history trade-offs. Such measures include reactive oxygen species production, oxidative repair, mitochondrial biogenesis, cell proliferation, mitochondrial DNA mutation and replication error and, importantly, a measure of the respiratory function to determine whether measured differences in bioenergetic state are associated with a change in the energetic capacity of tissues that could feasibly affect future reproduction or lifespan. More careful consideration of the life-history context and bioenergetic variables will improve our understanding of the mechanisms that underlie the life-history patterns of animals.

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Section: Loss Of Somatic Storesmentioning

confidence: 99%

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms

Zhang

Hood

2016

Journal of Experimental Biology

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“…In females, the Molluscan insulin-related peptide 5 [Genbank:CU987248] was more expressed in Danish progeny. In mammals, the role of insulin pathway in fertility is well known [65] and in fish the insulin pathway has been positively associated to gamete quality [66]. In C. gigas, an Insulin-related peptide receptor has previously been identified in oysters by Gricourt et al [67] as well as several factors of the insulin signalling pathway.…”

Section: Discussionmentioning

confidence: 99%

Additive transcriptomic variation associated with reproductive traits suggest local adaptation in a recently settled population of the Pacific oyster, Crassostrea gigas

et al. 2015

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“…Similar to mice, people treated with exogenous leptin were hyperphagic and hyperinsulinemic [5]. Also, excessive leptin secretion was related to infertility in obese women [6].…”

Section: Introductionmentioning

confidence: 92%

Association of serum and follicular fluid leptin and ghrelin levels with in vitro fertilization success

Akarsu¹,

Büke²,

Göde³

et al. 2017

Ginekol Pol

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Objectives: The aim of this study was to evaluate the relationship between in vitro fertilization (IVF) cycle outcomes, serum and follicular fluid (FF) levels of leptin and ghrelin. Material and methods:Forty-four women who underwent intracytoplasmic sperm injection cycles (ICSI) were enrolled in the study. On the third day (D3) of the menstrual cycle, venous blood samples were drawn for serum measurements of leptin and ghrelin. The follicular fluid (FF) and the corresponding oocyte were obtained from a single dominant preovulatory follicle at the time of oocyte pick-up. The FF and D3 serum leptin and ghrelin concentrations were measured by enzyme-linked immunosorbent assay. The relationship between pregnancy rate and serum, follicular fluid levels of leptin and ghrelin were analyzed. Results:Of the 44 cases included, nineteen achieved clinical pregnancy (43.18%). Follicular fluid ghrelin levels were significantly lower in the pregnant group than non-pregnant group (p < 0.05) With respect to FF leptin, there was no statistically significant differences between the pregnant and non-pregnant women (p > 0.05). There was no statistically significant difference in D3 serum ghrelin between pregnant and non-pregnant groups (p > 0.05). However, D3 serum leptin levels were significantly lower in pregnant women than non-pregnant women (p < 0.05). Conclusions:Lower ghrelin levels in the follicular fluid were associated with higher pregnancy rates. Also, D3 serum leptin levels were inversely correlated with clinical pregnancy rates. These findings support the potential role of these molecules on IVF outcomes.

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The relationship between gut and adipose hormones, and reproduction

Cited by 130 publications

References 290 publications

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms

Current versus future reproduction and longevity: a re-evaluation of predictions and mechanisms

Additive transcriptomic variation associated with reproductive traits suggest local adaptation in a recently settled population of the Pacific oyster, Crassostrea gigas

Association of serum and follicular fluid leptin and ghrelin levels with in vitro fertilization success

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