The Relationship between Hierarchical Chiral Structures of Proteins and their Functions

Malyshko, E. V.; Bagrova, Olga E.; Твердислов, В. А.

doi:10.1134/s0006350920030148

Cited by 2 publications

(1 citation statement)

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“…In addition to the previously obtained results [49], the distribution of secondary helical structures and coiled coils in the polypeptide chains of proteins of eight functional classes: virus protein, chaperone, oxidoreductase, hydrolase, structural proteins, exocytosis/endocytosis proteins, and electron transport proteins were analyzed. Proteins were selected using the PDB [45] and CC+ [46] databases.…”

Section: Distributions Of Helical and Superhelical Structures In Polypeptide Chainsmentioning

confidence: 99%

Protein Helical Structures: Defining Handedness and Localization Features

et al. 2021

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The quantitative evaluation of the chirality of macromolecule structures remains one of the exciting issues in biophysics. In this paper, we propose methods for quantitative analysis of the chirality of protein helical and superhelical structures. The analysis of the chirality sign of the protein helical structures (α-helices and -helices) is based on determining the mixed product of every three consecutive vectors between neighboring reference points—α-carbons atoms. The method for evaluating the chirality sign of coiled-coil structures is based on determining the direction and value of the angle between the coiled-coil axis and the α-helices axes. The chirality sign of the coiled coil is calculated by averaging the value of the cosine of the corresponding angle for all helices forming the superhelix. Chirality maps of helical and superhelical protein structures are presented. Furthermore, we propose an analysis of the distributions of helical and superhelical structures in polypeptide chains of several protein classes. The features common to all studied classes and typical for each protein class are revealed. The data obtained, in all likelihood, can reflect considerations about molecular machines as chiral formations.

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Section: Distributions Of Helical and Superhelical Structures In Polypeptide Chainsmentioning

confidence: 99%