The relationship between high intensity activities and kidney stone: A cross-sectional survey of NHANES

Abstract

Background Kidney stone disease (KSD) occurs in a wide range of ages and is influenced by multiple factors. Early detection and elimination of risk factors for KSD can effectively reduce the incidence of KSD. Methods In this research, we included KSD participants from the National Health and Nutrition Examination Survey (NHANES) database from 2007 to 2015. Baseline characteristics of the participants were investigated using Student's t-tests and chi-square tests. Subsequently, the relationship between high intensity activities (HIA) and KSD was investigated through multifactor glm regression modeling. In addition, the linear relationship between them was explored by smoothing curves. Finally, the predictive performance of HIA on KSD was explored based on receiver operating characteristic (ROC) curves. Results At first, 6,642 subjects were finally recruited for this study. The baseline statistical table showed that the exposure factor (time spent in HIA) was chosen to have a significant differentiation for KSD. In addition, HIA was significantly associated with KSD in all three models, with OR greater than 1 and P < 0.05. The smoothed curves showed that short periods of HIA did not increase the risk of KSD, but over a certain period of time greatly increased the risk of KSD. Stratified analysis results showed that exposure factors and race, educational status, and gout were significantly associated with KSD in Model 3. Eventually, ROC curve indicated the prediction for HIA to KSD was relatively accurate. Conclusion This study revealed a link between HIA and KSD, with HIA over a certain period of time greatly increasing the risk of KSD.