The relationship between histologic grades of invasive carcinoma of breast ducts and mast cell infiltration

Abstract

Introduction:Breast carcinoma is the most prevalent tumors among women. Transformation of inflated cells in immune response leads to increase in inflammatory cells such as macrophages, mast cells (MC) and fibroblasts. The aim of this study was to determine the relationship between grades of invasive carcinoma of the breast ducts and MC infiltration around tumoral cells.Methods:During the present study, 75 female patients suffering from invasive ductal carcinoma who underwent surgery or diagnostic biopsy during 2010 and 2013 in Educational-Medical centers of Tabriz University of Medical Sciences, were included in the study. Based on Bloom-Richardson grading system, 25 cases were selected from each grade. To better observe of MCs, samples were stained by Toluidine blue and MCs were counted in 10 40 × 10 fields.Results:The mean age was 47.56 ± 10.84 and the number of MCs was between 6 and 96 and their overall average was 43.01. Average count of MCs in grade 1, 2 and 3 were 15.92 ± 10.07, 45.32 ± 10.47, and 67.8 ± 20.70, respectively. There was a significant relationship between the number of MCs and increase in disease grade (P < 0.001). With increasing grade of malignancy, the number of MCs had grown. No significant relationship was observed between age and grade of disease or age and number of MC.Conclusion:According to obtained results, number of MC around tumoral cells increased significantly with an increase in the grade of disease. In order to treat in the first stages of the disease, recognizing primary changes in the stroma of cells could be helpful.

Mast Cell, the Neglected Member of the Tumor Microenvironment: Role in Breast Cancer

“…A recent study by Keser et al found that mast cells were present in all invasive primary tumors and in the metastatic lymph nodes [ 98 ]. In previous studies, mast cells were generally observed in the stroma adjacent to the neoplastic cells and near vascular structures [ 87 , 88 , 99 ]. Confusingly, while mast cells were detected in all metastatic lymph nodes, not all enlarged lymph nodes with evidence of immune reactivity (reactive lymph nodes) showed evidence of their presence.…”

“…Thus, peritumoral mast cells seem to contribute to breast cancer progression. Fakhrjou et al also found a positive association between the number of mast cells and the histopathological grade of the disease, particularly in invasive ductal carcinoma [ 99 ].…”

An In Vitro Model of Mast Cell Recruitment and Activation by Breast Cancer Cells Supports Anti-Tumoral Responses

“…The MC role in cancer progression is controversial; while some studies associate high tumor MC density with BrC subtypes of good prognosis or with favorable clinical outcomes [ 5 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 ], others find them associated with aggressive features [ 23 , 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ]. One potential problem of current approaches to elucidate the participation of MCs in BrC progression, is that most studies are observational and correlative, and until now the molecular mechanisms have not been elucidated.…”

Similar outcomes between adenoid cystic carcinoma of the breast and invasive ductal carcinoma: a population-based study from the SEER 18 database

“…To treat patients with heterogeneous cancer, it is critical to understand the specific biological characteristics associated with the prognosis and outcomes of a given histological type. Approximately 83% of invasive breast cancers are classified as invasive ductal carcinoma, not otherwise specified (IDC-NOS) [2, 3], whereas approximately 0.1%~1% are defined as adenoid cystic carcinoma (ACC) [1, 3]. Based on its clinicopathological characteristics and outcomes, ACC is distinct from IDC-NOS.…”