The relationship between homeobox B7 expression and the clinical characteristics of patient with prostate cancer

Abstract

Background The prognosis of patients with prostate cancer (PCa) remains poor. Methods GSE16560, GSE32448, GSE79957, GSE17951, and TCGA‐PRAD were reanalyzed to evaluate the expression of homeobox B7 (HOXB7) between PCa tissues and normal prostate tissues and to characterize the correlation between the expression of HOXB7 and the clinicopathological features of patients with PCa. Gene set enrichment analysis was conducted to investigate the mechanisms. Results HOXB7 was upregulated in PCa tissues (P = 0.0005). Both the univariate and multivariate analyses demonstrated that the expression of HOXB7 was correlated with the Gleason score and TNM staging of patients with PCa. The Gleason score and TNM staging were higher in the HOXB7 high expression group. The overall survival (hazard ratio [HR] = 0.632; 95% confidence interval [CI]: 0.4773‐0.8369; P = 0.0014) and progression‐free survival (HR = 0.544; 95% CI: 0.3157‐0.9373; P = 0.0283) favored patients with PCa in HOXB7 low expression group over those in HOXB7 high expression group. PCa samples in HOXB7 low expression group were enriched in gene sets associated with the epithelial mesenchymal transition, apical junction, angiogenesis, ultraviolet response, and hypoxia. Conclusions HOXB7 might be an independent prognostic factor of patients with PCa.

JAG1 Intracellular Domain Enhances AR Expression and Signaling and Promotes Stem-like Properties in Prostate Cancer Cells

“…Human estrogen receptor-related receptor gamma (ERRγ) was reported to suppress cell proliferation and tumor growth of androgen-sensitive and androgen-insensitive PC cells [ 68 ] and JICD overexpression resulted in a depletion of ERRγ ( Figure S6A , ESRRG). In addition, homeobox (HOX) genes such as HOXB7 [ 69 ], HOXC8 [ 70 ], and HOXB13 [ 71 ], which are used as PC diagnostic markers, are involved in malignant cell transformation and/or cancer progression. HOXB13 is also a pivotal upstream regulator of AR-V7-driven transcriptomes that are often cell context-dependent in CRPC [ 71 ].…”

HOXB7 acts as an oncogenic biomarker in head and neck squamous cell carcinoma

“…Moreover, previous studies have shown that abnormally elevated HOXB7 expression was significantly associated with tumor size, cervical lymph node metastasis, malignancy, and etc. [ 32 , 35 ]. Consistently, our data revealed that both bioinformatics analyses from multiple independent patient cohorts and immunohistochemistry in primary HNSCC samples revealed aberrant overexpression of HOXB7 in a large subset of patients examined.…”

The significance of HOXB7 and IL17RB serum levels in prognosis of hormonally dependent breast cancer: A pilot study

“…As mentioned above, the prognostic value of intratumoral expression of HOXB7 and IL17RB has already been reported in the breast [13,14] and other cancers [15]. However, there are also reports that even serum levels of several intracellular proteins exert diagnostic or prognostic value [16,17].…”

“…First of all, please make sure to point out -in the text -the STRENGTHS and the NOVELTY of your study. Author response: According to this suggestion of the Editor, we have now expanded the explanation of strengths and novelty of the current study (Abstract, lines 2-7; Introduction section, page 2, lines 2-11 and Discussion section, page 12, lines [13][14][15][16][17][18].…”