The relationship between immature platelet fraction and severity of acute bronchiolitis

Doğan, Murat; Köse, Mehmet; Öztürk, Mehmet; Hangül, Melih; Aslaner, Hümeyra

doi:10.24953/turkjped.2021.06.014

Cited by 3 publications

(1 citation statement)

References 22 publications

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“…The WBC count will increase when there is infection and inflammatory reaction is intense, which is a defensive reaction of the body. Studies have shown that WBC counts can be used to predict and diagnose the severity of bronchiolitis ( 15 ). The rise of APTT indicates that the blood is in a hypercoagulable state, which is caused by the release of various inflammatory factors and clotting substances during infection ( 16 ).…”

Section: Discussionmentioning

confidence: 99%

A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis

et al. 2022

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ObjectivesPrediction of the efficacy of continuous positive airway pressure (CPAP) on bronchiolitis is necessary for timely treatment. This study aims to establish a nomogram for efficacy of CPAP on bronchiolitis, and compares accuracy with Pediatric Risk of Mortality III (PRISM III), Brighton Pediatric Early Warning Score (Brighton PEWS) and Pediatric Critical Illness Score (PCIS).MethodsFrom February 2014 to December 2020, data on children diagnosed with bronchiolitis and treated with CPAP in Chongqing was collected. The nomogram was evaluated by using multivariate logistic regression analysis. We compared the predictive value of model with PRISM III, PEWS and PCIS.ResultsA total of 510 children were included. The nomogram prediction model including fever, APTT, white blood cells, serum potassium concentration, lactic acid, immunodeficiency, atelectasis, lung consolidation, congenital airway dysplasia and congenital heart disease was established. The AUC of the nomogram was 0.919 in the training set and 0.947 in the validating set. The model fitted well, as evidenced by the calibration curve and Hosmer-Lemeshow goodness-of-fit test. We discovered that the nomogram significantly performed better than PRISM III, PCIS and PEWS.ConclusionsA nomogram including ten factors for predicting the efficacy of CPAP on bronchiolitis was established. It had higher performance than the PRISM III, PCIS, and PEWS in terms of clinical benefits.

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Section: Discussionmentioning

confidence: 99%

A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis

et al. 2022

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Early prediction of platelet recovery with immature platelet fraction in patients receiving hematopoietic stem cell transplantation

Yang,

Tsai,

Wang

et al. 2024

Ann Hematol

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Hematopoietic stem cell transplantation (HSCT) is pivotal in treating hematologic disorders, yet it poses the risk of post-transplantation pancytopenia. Prophylactic platelet transfusions are often administered to mitigate this risk. Utilizing practical markers, such as immature platelet fraction (IPF), to predict hematopoietic recovery in advance could reduce unnecessary prophylactic transfusions. Our prospective study, involving 53 HSCT patients at Taipei Veterans General Hospital between September 2022 and May 2023, utilized the Sysmex XN analyzer to assess peripheral blood cell parameters. We investigated whether IPF could predict platelet recovery early, determined the optimal cut-off value, and compared platelet usage. Neutrophil and platelet engraftment occurred 10 (median; range: 10–12) and 15 (median; range: 15–18) days post-HSCT. Notably, 71.7% of patients exhibited an IPF increase exceeding 2% before platelet recovery. The optimal cut-off IPF on day 10 for predicting platelet recovery within five days was 2.15% (specificity 0.89, sensitivity 0.65). On average, patients received 3.89 units of post-transplantation platelet transfusion. Our results indicate that IPF serves as a predictive marker for platelet engraftment, peaking before the increase in platelet count. This insight aids clinicians in assessing the need for prophylactic platelet transfusions. Integrating reference IPF values alongside platelet counts enhances the accuracy of evaluating a patient’s hematopoietic recovery status. Anticipating the timing of platelet recovery optimizes blood product usage and mitigates transfusion reaction risks.

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Role of Serum Endocan Levels in Children with Bacterial and Viral Pneumonia: A Prospective, Case-Control Study

Taşar

Fidancı

Bulut

et al. 2022

Pediatric Allergy, Immunology, and Pulmonology

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The relationship between immature platelet fraction and severity of acute bronchiolitis

Cited by 3 publications

References 22 publications

A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis

A prediction model for the efficacy of continuous positive airway pressure on bronchiolitis

Early prediction of platelet recovery with immature platelet fraction in patients receiving hematopoietic stem cell transplantation

Role of Serum Endocan Levels in Children with Bacterial and Viral Pneumonia: A Prospective, Case-Control Study

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