The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis

Park, Mijung; Park, Pil-Whan; Seo, Yiel-Hea; Kim, Kyung Hee; Park, Soon-Ho; Jeong, Ji-Hun; Ahn, Jeong Yeal

doi:10.3109/09537104.2012.699641

Cited by 56 publications

(45 citation statements)

References 24 publications

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“…Anemia, especially when caused by iron deficiency, can sometimes lead to thrombocytosis, which is a risk factor for venous thrombosis. 25,26 This mechanism would be in line with the fact that we observed a stronger association between CVT and microcytic anemia because iron deficiency is the most important cause of microcytic anemia. Unfortunately, thrombocytes were not measured in the MEGA study, and thus we could not examine whether the presence of thrombocytosis modified the association between anemia and CVT.…”

Section: Discussionsupporting

confidence: 82%

Association Between Anemia and Cerebral Venous Thrombosis

Coutinho

Zuurbier

Gaartman

et al. 2015

Stroke

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Background and Purpose— Anemia is often considered to be a risk factor for cerebral venous thrombosis (CVT), but this assumption is mostly based on case reports. We investigated the association between anemia and CVT in a controlled study. Methods— Unmatched case–control study: cases were adult patients with CVT included in a single-center, prospective database between July 2006 and December 2014. Controls were subjects from the control population of the Multiple Environmental and Genetic Assessment of Risk Factors for Venous Thrombosis (MEGA) study. Anemia was defined according to World Health Organization criteria: nonpregnant women hemoglobin <7.5 mmol/L, pregnant women <6.9 mmol/L, and men <8.1 mmol/L. We used logistic regression analysis, adjusting for age, sex, malignancy, oral contraceptive use, and pregnancy/puerperium. Results— We included 152 cases and 2916 controls. Patients with CVT were younger (mean age, 40 versus 48 years) and more often women (74% versus 53%) than controls. Anemia was more frequent in cases (27.0%) than in controls (6.5%; P <0.001). Anemia was associated with CVT, both in univariate analysis (odds ratio, 5.3; 95% confidence interval [CI], 3.6–7.9) and after adjustment for potential confounders (adjusted odds ratio, 4.4; 95% CI, 2.8–6.9). Hemoglobin as a continuous variable was inversely associated with CVT (adjusted odds ratio per 1 mmol/L change 0.53; 95% CI, 0.42–0.66). Stratification by sex showed a stronger association between anemia and CVT in men (adjusted odds ratio, 9.9; 95% CI, 4.1–23.8) than in women (3.6; 95% CI, 2.1–6.0). Conclusion— Our data suggest that anemia is a risk factor for CVT.

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Section: Discussionsupporting

confidence: 82%

Association Between Anemia and Cerebral Venous Thrombosis

Coutinho

Zuurbier

Gaartman

et al. 2015

Stroke

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“…These values enable clinicians to apply such indices in research on various diseases. In the current study, consistent with previous reports (11), IS was the most important factor affecting platelet counts.…”

Section: Discussionsupporting

confidence: 93%

Survey of Correlation Between Serum Transferrin Saturation and Platelet Indices in High School Female Students in the Northwest Iran

Rafieemehr¹,

Rafiee²,

Mahmoodi³

et al. 2017

Int J School Health

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Background: Platelet indices (PIs), including platelet count (PC), mean platelet volume (MPV), platelet distribution width (PDW), and platelet larger cell ratio (P-LCR) are used to predict clinical outcomes in patients with various medical conditions. The current study aimed at evaluating the correlation between serum iron saturation (IS) and PIs among the female students living in the Northwest of Iran. Methods: The current cross sectional study included 254 high school female (HSF) students aged 15 to 18 years in Hamadan, Iran, from September to January 2016. After completion of a questionnaire, the hematological parameters were determined using standard methods. HSF afflicted with infections and acute hemorrhage, and the ones with malignancies and inflammatory diseases were excluded. The correlation between the serum levels of IS and PIs in the female residents of Northwest of Iran was evaluated using the Pearson correlation test.

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“…Several studies have suggested a link between iron deficiency and thrombocytosis in non-CKD patients. 9,21,22 Furthermore, ESA dose was one of the independent determinants of TSAT, and vice versa. 23 Also, ESA-associated venous thromboembolism could be caused by iron-restricted erythropoiesis and would be countered by iron supplementation in non-CKD patients.…”

Section: Discussionmentioning

confidence: 98%

Regulation of platelet count by erythropoiesis-stimulating agents – iron axis in hemodialysis patients

Koike

Fukami

Kawaguchi

et al. 2016

IJNRD

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Higher doses of erythropoiesis-stimulating agents (ESAs) contribute to atherothrombotic cardiovascular disease in hemodialysis (HD) patients. Thrombocytosis is associated with increased mortality in ESA-treated HD patients. We investigated variables affecting platelet count and its variability (platelet count increment [∆platelet count]) in HD patients. This retrospective longitudinal and observational study of HD outpatients was carried out over 3 years. The outcome was independent determinants of platelet count and ∆platelet count, which were associated with iron indices, ESA dose, and C-reactive protein. In univariate regression analysis, V-shaped relationship was observed between platelet count and transferrin saturation (TSAT), ferritin, serum iron, and hemoglobin (Hb) with the bottom of 0.21, 330 ng/mL, 49 µg/ dL, and 10.3 g/dL, respectively. Mixed-effect multivariate regression analysis revealed that TSAT (inversely), Hb #10.3 g/dL (inversely), C-reactive protein, and ESA dose were independently associated with platelet count. ∆platelet count was independently and inversely correlated with ∆TSAT and directly correlated with ∆ferritin. TSAT was independently and inversely associated with ESA dose. ESA dose was directly correlated with iron dose and inversely correlated with TSAT, ferritin #330 ng/mL, and Hb #10.3 g/dL. ESA dose and TSAT were correlated in determining platelet count and ∆platelet count. Targets of iron indices that reflect iron supply sufficient to avoid platelet count increment and variability may be .21% of TSAT and 300 ng/mL of serum ferritin for appropriate ESA therapy in HD patients.

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The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis

Cited by 56 publications

References 24 publications

Association Between Anemia and Cerebral Venous Thrombosis

Association Between Anemia and Cerebral Venous Thrombosis

Survey of Correlation Between Serum Transferrin Saturation and Platelet Indices in High School Female Students in the Northwest Iran

Regulation of platelet count by erythropoiesis-stimulating agents – iron axis in hemodialysis patients

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The relationship between iron parameters and platelet parameters in women with iron deficiency anemia and thrombocytosis

Cited by 56 publications

References 24 publications

Association Between Anemia and Cerebral Venous Thrombosis

Association Between Anemia and Cerebral Venous Thrombosis

Survey of Correlation Between Serum Transferrin Saturation and Platelet Indices in High School Female Students in the Northwest Iran

Regulation of platelet count by erythropoiesis-stimulating agents &ndash; iron axis in hemodialysis patients

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Regulation of platelet count by erythropoiesis-stimulating agents – iron axis in hemodialysis patients