The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

Aghaie, Zohreh; Hajian, Sepideh; Abdi, Fatemeh

doi:10.15419/bmrat.v5i8.468

Cited by 3 publications

(2 citation statements)

References 38 publications

(48 reference statements)

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“…It is known that many factors affect lipid levels in GDM because carbohydrate metabolism directly affects lipid metabolism. There is still controversy over the association between lipid profile and GDM [ 12 ]. Although lipid levels have been extensively studied during pregnancy, there are conflicting results in this regard.…”

Section: Introductionmentioning

confidence: 99%

Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

et al. 2021

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Gestational diabetes mellitus (GDM) can have adverse effects on pregnancy. GDM is associated with changes in the lipid profile of pregnant women. Finding out the early ways to diagnose GDM can prevent the adverse outcomes. This meta-analysis study aimed to determine the effect of GDM on lipid profile. PubMed, ProQuest, Web of Science, Scopus, Science Direct, Google Scholar, and ClinicalTrial were systematically searched for published articles relating to GDM until 2021 according to PRISMA guidelines. Newcastle Ottawa scale was used to assess the quality of the studies. Thirty-three studies with a sample size of 23,792 met the criteria for entering the meta-analysis. Pooled standardized mean difference (SMD) for total cholesterol (TC) and triglyceride (TG) was 0.23 mg/dL (95% CI: 0.11–0.34) and 1.14 mg/dL (95% CI: 0.91–1.38), respectively. The mean of TC and TG in people with GDM was higher than that in normal pregnant women. A similar pattern was observed for the very low-density lipoprotein (VLDL) and TG/high-density lipoprotein (HDL) ratio, with pooled SMD of 0.99 mg (95% CI: 0.71–1.27) and 0.65 mg (95% CI: 0.36–0.94), respectively. Pooled SMD for HDL was −0.35 mg/dL (95% CI: −0.54 to −0.16), women with GDM had a mean HDL lower than normal pregnant women. Although pooled SMD was higher for low-density lipoprotein (LDL) in the GDM group, this difference was not significant (0.14 [95% CI: −0.04 to 0.32]). Of all the lipid profiles, the largest difference between the GDM and control groups was observed in TG (SMD: 1.14). Elevated serum TG had the strongest effect on GDM. Higher levels of TC, LDL, VLDL, and TG/HDL ratio, and lower level of HDL were exhibited in GDM group. So, these markers can be considered as a reliable marker in the diagnosis of GDM.

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Section: Introductionmentioning

confidence: 99%

Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

et al. 2021

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“…Campolong, et al., [2] agrees that there are three stages of pregnancy, known as trimesters. In pregnancy, lipid metabolism undergoes complicated changes; lipid levels such as Low-density Lipoprotein (LDL), High-density Lipoprotein (HDL), Total Cholesterol (TC), and Triglyceride, above or below the normal range can lead to pregnancy complications that may end up to preterm delivery [3].…”

Section: Introductionmentioning

confidence: 99%

Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria

Eziechile¹,

Oguji²,

Chukwu³

et al. 2022

Int. J. Sci. Res. Arch.

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Background: In pregnancy which is a physiological state that is accompanied by high energy demand, there is an increased intake and utilization of oxygen, hence augmented levels of oxidative changes that are associated with a lot of risks, one of which is cardiovascular diseases. This research aims to investigate the oxidative changes that occur among pregnant women by determining the levels of High Sensitivity c-Reactive Protein (hs-CRP) and Oxidized Low-Density Lipoprotein (OxLDL) in first, second and third trimesters. Materials and Methodology: A total of 60 pregnant women were recruited for the study. Twenty (20) pregnant women each from the three trimesters while Twenty (20) non-pregnant pubertal women without any chronic disease were used as control. 5ml of venous blood was collected from all subjects and analyzed for OxLDL and hs-CRP using an Enzyme-Linked Immunosorbent Assay (ELISA) technique. The data were analyzed using Statistical Package for the Social Sciences (SPSS) version 18. Results: Oxidized Low-Density Lipoprotein (OxLDL) showed mean variations across the groups but was not significant (P>0.05) but Pregnant women in their second trimester showed significant mean variation (P<0.05) (3716.11±599.86) in when compared to non-pregnant women (control) (4305.33±68.90) respectively. Pregnant women in the second trimester showed significantly decreased mean variation (P<0.05) in High sensitivity C-reactive protein (85.09 ±12.38) when compared to non-pregnant women (control) (219.45 ±64.61) respectively. Conclusions: This study shows that there are increases in levels of OxLDL and a decrease in plasma concentration of hs-CRP which are more significant in the second trimester.

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Research Progress on Abnormal Lipid Metabolism in Pregnancy

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2024

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The relationship between lipid profiles in pregnancy and preterm delivery: a systematic review

Cited by 3 publications

References 38 publications

Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

Effect of gestational diabetes mellitus on lipid profile: A systematic review and meta-analysis

Assessment of oxidative and cardiovascular changes in pregnant women attending antenatal clinic at Federal Medical Centre, Owerri Nigeria

Research Progress on Abnormal Lipid Metabolism in Pregnancy

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