The Relationship Between Liver Enzymes and Insulin Resistance in Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease

Sheng, Xia; Che, Hui; Ji, Qingming; Yang, Fan; Lv, Jie; Wang, Yueqiu; Xian, Huimin; Wang, Lihong

doi:10.1055/a-0603-7899

Cited by 41 publications

(37 citation statements)

References 31 publications

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“…However, not all the studies supported the above conclusion. Sheng et al reported that some NAFLD patients possessed the normal ALT value, and the residual NAFLD patients had the elevated level of ALT [13]. Amarapurkar et al reported that the histological and clinical manifestation of NAFLD and NASH patients with normal ALT value were not different with the NAFLD and NASH patients with elevated ALT value [22].…”

Section: Discussionmentioning

confidence: 99%

“…After removed the duplication, reviews, animal studies, and irrelevant resources, 34 potential studies were selected to further evaluation. After excluded 23 improper studies, a total of 11 studies with 4084 patients [13][14][15][21][22][23][24][25][26][27][28] which matched the inclusion criteria were included in this meta-analysis.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most of the time, only subjects who with increased ALT values were enrolled in the clinical investigation or trials. In most of the previous studies, the higher ALT values were tightly associated with the higher risk of NAFLD especially with the NASH [11,12], but some other studies showed that NAFLD or NASH patients which measured by histology, MRI and ultrasonography possessed the normal ALT value [13][14][15]. Moreover, some studies showed that patients with normal ALT levels had the histological features of disease progression [16,17].…”

Section: Introductionmentioning

confidence: 99%

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Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

et al. 2020

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Background: ALT value is often used to reflect the hepatic inflammation and injury in NAFLD patients, but many studies proved that ALT values were normal in many NAFLD patients. The aim of this study was to identify the summarized proportion of NAFLD patients with normal ALT value in the overall NAFLD patients. Methods: Electronic databases PubMed, EMBASE, Ovid, and the Cochrane Library were searched for potential studies published from . Studies that have reported the number of NAFLD or NASH patients with normal and abnormal ALT value were included and analyzed. Abstracts, reviews, case reports, and letters were excluded.Results: A total of 11 studies with 4084 patients were included for assessing the summarized proportion of NAFLD patients with normal ALT in overall NAFLD patients. As the results shown, the summarized proportion of NAFLD patients with normal ALT value in overall NAFLD patients was 25% (95%CI: 20-31%) which was calculated by the random-effects model. The summarized proportion of NASH patients with normal ALT value in overall NASH patients was 19% (95%CI: 13-27%). Subgroup analysis includes region, study type, diagnostic method, and group size were conducted to investigate the resource of heterogeneity in the summarized proportion of NAFLD and NASH patients with normal ALT value. Conclusions: 25% NAFLD patients and 19% NASH patients possess the normal ALT value in the clinical manifestation. The value of ALT in the clinical diagnosis of NAFLD and NASH remains need be further testified.

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Section: Discussionmentioning

confidence: 99%

Section: Study Characteristicsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

et al. 2020

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“…The pathogenesis of NAFLD can be introduced by a model, which is a two-hit theory, in which it is stated that the disease is caused by the first-hit due to insulin resistance, obesity and dyslipidemia, and due to the second-hits, such as oxidative stress, pro-inflammatory cytokines and intestinal bacterial toxins, ultimately inflammation and fibrosis of liver cells are occurred (37). On the other hand, liver enzymes, like ALT, as an indicator of oxidative stress and inflammation are factors resulting in insulin resistance (38).…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Predictors of Non-Alcoholic Fatty Liver Disease in Obese and Overweight Children in the Northwest of Iran

et al. 2019

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Background: Over recent decades, with the increase in the prevalence of childhood overweight/obesity, the prevalence of pediatric non-alcoholic fatty liver disease (NAFLD) has increased. Objectives: The aim of this study was to investigate the prevalence of NAFLD and its predisposing factors in overweight and obese children of Urmia, Northwest of Iran. Methods: In this cross-sectional study, a total of 843 children aged 2 to 19 years were recruited out of 10800 children referred to the Digestive Disease Clinic of Shahid Motahari Hospital during 2016-2017. Anthropometric and laboratory measurements and abdominal ultrasound were performed for the children. Demographic data and their medical history were collected by a questionnaire. Unconditional logistic regression was used to predict the predisposing factors of NAFLD. Results: Fatty liver was diagnosed by ultrasound in 9.5% of overweight and 21.4% of obese children. The prevalence of NAFLD in obese children was 9.26% for the 2-5.9-year age group, 22.3% for the 6-11.9-year age group and 35.5% for the 12-19-year age group. Compared to the normal liver group, the adjusted odds ratios (ORs) [95% confidence interval (CI)] for predictive factors of NAFLD were as follows: ALT

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“…The extract of Erythrina abyssinica had significant effects on the serum alanine amino-transferase levels (ALT) which are a recognized marker of hepatocellular injury. Indeed, several epidemiologic association studies have shown that this enzyme is elevated in, and consequently can be used as a biomarker of NAFLD [52][53][54].…”

Section: Discussionmentioning

confidence: 99%

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

Yenesew

et al. 2019

Preprint

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Background: Non-alcoholic fatty liver disease (NFLD) is the hepatic manifestation of the metabolic syndrome recognized as the most prevalent chronic liver disease across all age groups. NFLD is strongly associated with obesity, insulin resistance, hypertension and dyslipidemia. Extensive research efforts are geared, through pharmacological approach, towards preventing or reversing this. Erythrina abyssinica Lam ex DC is an indigenous tree used widely used in traditional medicine, including for the treatment of liver related diseases, and has been shown to possess hypoglycemic, anti-oxidant, antimicrobial and anti-plasmodia effects. The present study is aimed at establishing the effects of E. abyssinica on the development of Non-alcoholic fatty liver disease induced by a high-fat and high-sugar diet in rats, in-vivo model. (40) were randomly divided into five groups: positive control (pioglitazone), Negative control (high fat/high sugar diet), low test dose (200 mg/kg), high test dose (400 mg/kg) and normal group (standard chow pellets and fresh water). Methods: Forty ratsThe inhibitory effect of the stem bark extract of E. abyssinica on the development of NAFLD was evaluated by chronic administration the herb extracts to rats on a high-fat/high-sugar diet.Biochemical indices of hepatic function including serum lipid profile, serum aspartate transaminase and alanine transaminase levels were then determined. Histological analysis of liver samples was carried out to quantify the degree of steato-hepatitis. Liver weights were taken and used to determine the hepatic index. The data was analyzed using one-way ANOVA, and Tukey's post-hoc tests were done in cases of significance. Histology data was analyzed using Kruskal-Wallis and Dunn's post-hoc test was done in cases of significance. Significance was set at p<0.05. Results:The freeze dried extract of E. abyssinica had significant effects on fasting blood glucose [5.43 ± 0.17 (HF/HSD) vs 3.8 ± 0.15 (E 400 mg/kg) vs 4.54 ± 0.09 (E 200 mg/kg) vs. 4.16 ± 0.13 (PIOG) vs. 2.91 ± 0.16 (normal control): P value < 0.0001], and insulin sensitivity [329.4 ± 13.48 mmol/L · min (HF/HSD) vs. 189.8 ± 12.11 mmol/L · min (E 400 mg/kg) vs. 233.8 ± 6.55 mmol/L · min (E 200 mg/kg) vs. 211.1 ± 7.35 mmol/L · min (PIOG) vs. 142.9 ± 11.94 mmol/L · min: P value < 0.0001],The extract had significant effects on hepatic indices including, hepatic triglycerides (P value < 0.0001), liver weights (P value < 0.0001), liver weight-body weight ratio (P value < 0.0001), serum ALT levels (P value < 0.0001), serum AST (P value < 0.0017), serum total cholesterol (P value < 0.0001), serum triglycerides (P value < 0.0001), and serum LDL-cholesterol (P value < 0.0001). The extracts however showed no significant effects on HDL-cholesterol (P value = 0.4759).Histological analysis showed that the extract appears to possess protective effects against steatosis, inflammation and hepatic ballooning, with the high dose (400mg/kg) being more hepatoprotective. Conclusion:The freeze dried stem bark extract of Eryth...

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The Relationship Between Liver Enzymes and Insulin Resistance in Type 2 Diabetes Patients with Nonalcoholic Fatty Liver Disease

Cited by 41 publications

References 31 publications

Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

Proportion of NAFLD patients with normal ALT value in overall NAFLD patients: a systematic review and meta-analysis

Prevalence and Predictors of Non-Alcoholic Fatty Liver Disease in Obese and Overweight Children in the Northwest of Iran

Hepatoprotective effects ofErythrina abyssinicaLam Ex Dc against Non Alcoholic Fatty Liver Disease in Sprague Dawley Rats

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