The Relationship between Long-Term Blood Pressure Variability and Cortical Thickness in Older Adults

Gutteridge, Daria S.; Segal, Ashlea; McNeil, John J; Beilin, Lawrence J.; Brodtmann, Amy; Chowdhury, E.; Egan, Gary F.; Ernst, Michael E.; Hussain, Malik Asif; Reid, C.; Robb, Catherine; Ryan, Joanne; Woods, Robyn L.; Keage, Hannah; Jamadar, Sharna

doi:10.2139/ssrn.4341720

Cited by 2 publications

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“…This later result is consistent with that seen in cortical thickness. In Gutteridge et al, we found that long-term variability in diastolic, and not systolic, blood pressure was an important influence on cortical thickness in older age 66 . Of note, in the current study we obtained a single measure of blood pressure at a single timepoint, whereas in Gutteridge et al variability in blood pressure over three years was examined.…”

Section: Discussionmentioning

confidence: 45%

The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance

Deery,

Liang,

Di Paolo

et al. 2024

Sci Rep

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Rising rates of insulin resistance and an ageing population are set to exact an increasing toll on individuals and society. Here we examine the contribution of age and insulin resistance to the association of cerebral blood flow and glucose metabolism; both critical process in the supply of energy for the brain. Thirty-four younger (20–42 years) and 41 older (66–86 years) healthy adults underwent a simultaneous resting state MR/PET scan, including arterial spin labelling. Rates of cerebral blood flow and glucose metabolism were derived using a functional atlas of 100 brain regions. Older adults had lower cerebral blood flow than younger adults in 95 regions, reducing to 36 regions after controlling for cortical atrophy and blood pressure. Lower cerebral blood flow was also associated with worse working memory and slower reaction time in tasks requiring cognitive flexibility and response inhibition. Younger and older insulin sensitive adults showed small, negative correlations between relatively high rates of regional cerebral blood flow and glucose metabolism. This pattern was inverted in insulin resistant older adults, who showed hypoperfusion and hypometabolism across the cortex, and a positive correlation. In insulin resistant younger adults, the association showed inversion to positive correlations, although not to the extent seen in older adults. Our findings suggest that the normal course of ageing and insulin resistance alter the rates of and associations between cerebral blood flow and glucose metabolism. They underscore the criticality of insulin sensitivity to brain health across the adult lifespan.

show abstract

Section: Discussionmentioning

confidence: 45%

The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance

Deery,

Liang,

Di Paolo

et al. 2024

Sci Rep

View full text Add to dashboard Cite

show abstract

“…This later result is consistent with that seen in cortical thickness. In Gutteridge et al, we found that long-term variability in diastolic, and not systolic, blood pressure was an important influence on cortical thickness in older age [56]. Of note, in the current study we obtained a single measure of blood pressure at a single timepoint, whereas in Gutteridge et al variability in blood pressure over three years was examined.…”

Section: Discussionmentioning

confidence: 58%

Insulin resistance alters the coupling between cerebral blood flow and glucose metabolism in younger and older adults: Implications for neurovascular coupling

Deery,

Liang,

Di Paolo

et al. 2024

Preprint

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Rising rates of insulin resistance and an ageing population are set to exact an increasing toll on individuals and society. Here we examine the contribution of insulin resistance and age to the coupling of cerebral blood flow and glucose metabolism; a critical process in the supply of energy for the brain. Thirty-four younger (20-42 years) and 41 older (66-86 years) healthy adults underwent a simultaneous resting state MR/PET scan, including arterial spin labelling. Rates of cerebral blood flow and glucose metabolism were derived using a functional atlas of 100 brain regions. Older adults had lower cerebral blood flow than younger adults in 95 regions, reducing to 36 regions after controlling for cortical atrophy and blood pressure. Younger and older insulin sensitive adults showed small, negative correlations between relatively high rates of regional cerebral blood flow and glucose metabolism. This pattern was inverted in insulin resistant older adults, who showed hypoperfusion and hypometabolism across the cortex, and a positive coupling. In insulin resistant younger adults, coupling showed inversion to positive correlations, although not to the extent seen in older adults. Our findings suggest that the normal course of ageing and insulin resistance alter the rates and coupling of cerebral blood flow and metabolism. They underscore the criticality of insulin sensitivity to brain health across the adult lifespan.

show abstract

The Relationship between Long-Term Blood Pressure Variability and Cortical Thickness in Older Adults

Cited by 2 publications

References 0 publications

The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance

The association of regional cerebral blood flow and glucose metabolism in normative ageing and insulin resistance

Insulin resistance alters the coupling between cerebral blood flow and glucose metabolism in younger and older adults: Implications for neurovascular coupling

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