The relationship between major dietary patterns and disease activity of rheumatoid arthritis

Elahi, N Abd; Elahi, Homayoun; Navashenaq, Jamshid Gholizadeh; Abdollahzad, Hadi; Mahaki, Behzad; Soleimani, Davood; Mostafaei, Roghayeh; Samadi, Mehnoosh; Bagheri, Amir; Nachvak, Seyed Mostafa

doi:10.1016/j.clnesp.2022.08.016

Cited by 2 publications

(1 citation statement)

References 25 publications

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“…There is evidence that a low-fiber dietary pattern may be linked to increased RA disease activity. For example, Elahi and associates showed that patients with RA on a low-fiber diet exhibited greater disease activity compared with those adhering to diets of higher-fiber contents [ 59 ].…”

Section: Discussionmentioning

confidence: 99%

Mediterranean Diet and Physical Activity Nudges versus Usual Care in Women with Rheumatoid Arthritis: Results from the MADEIRA Randomized Controlled Trial

Παπανδρέου

Gioxari

Daskalou³

et al. 2023

Nutrients

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In rheumatoid arthritis (RA), diet quality and nutritional status have been shown to impact the disease activity and adherence to the Mediterranean diet (MD) has been suggested as an anti-inflammatory regime to improve disease status and reduce cardiovascular risk. The Mediterranean DiEt In Rheumatoid Arthritis (MADEIRA) was a single-blind (statistician), two-arm randomized clinical trial, investigating the effects of a 12-week lifestyle intervention, including a personalized isocaloric MD plan with the promotion of physical activity (PA), supported through a clinical decision support systems (CDSS) platform, versus usual care in women with RA. Forty adult women with RA on remission were randomly allocated (1:1 ratio) to either the intervention or the control arm. The intervention group received personalized MD plans and lifestyle consultation on improving PA levels, whereas the controls were given generic dietary and PA advice, based on the National Dietary Guidelines. The primary outcome was that the difference in the MD adherence and secondary outcomes included change in disease activity (DAS28), anthropometric indices (BodPod), dietary intake, PA, vitamin D concentrations, and blood lipid profiles after 12 weeks from the initiation of the trial. At 3 months post-baseline, participants in the MD arm exhibited greater adherence to the MD compared with the controls (p < 0.001), lower DAS28 (p < 0.001), favorable improvements in dietary intake (p = 0.001), PA (p = 0.002), body weight and body composition (p < 0.001), blood glucose (p = 0.005), and serum 1,25(OH)2D concentrations (p < 0.001). The delivery of the MD and PA promotion through CDSS nudges in women with RA in an intensive manner improves the MD adherence and is associated with beneficial results regarding disease activity and cardiometabolic-related outcomes, compared with the usual care.

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Section: Discussionmentioning

confidence: 99%

Mediterranean Diet and Physical Activity Nudges versus Usual Care in Women with Rheumatoid Arthritis: Results from the MADEIRA Randomized Controlled Trial

Παπανδρέου

Gioxari

Daskalou³

et al. 2023

Nutrients

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Gut Dysbiosis and Dietary Interventions in Rheumatoid Arthritis—A Narrative Review

Bakinowska,

Stańska,

Kiełbowski

et al. 2024

Nutrients

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Rheumatoid arthritis (RA) is a chronic and progressive autoimmune disease. The pathogenesis of RA is complex and involves interactions between articular cells, such as fibroblast-like synoviocytes, and immune cells. These cells secrete pro-inflammatory cytokines, chemokines, metalloproteinases and other molecules that together participate in joint degradation. The current evidence suggests the important immunoregulatory role of the gut microbiome, which can affect susceptibility to diseases and infections. An altered microbiome, a phenomenon known as gut dysbiosis, is associated with the development of inflammatory diseases. Importantly, the profile of the gut microbiome depends on dietary habits. Therefore, dietary elements and interventions can indirectly impact the progression of diseases. This review summarises the evidence on the involvement of gut dysbiosis and diet in the pathogenesis of RA.

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The relationship between major dietary patterns and disease activity of rheumatoid arthritis

Cited by 2 publications

References 25 publications

Mediterranean Diet and Physical Activity Nudges versus Usual Care in Women with Rheumatoid Arthritis: Results from the MADEIRA Randomized Controlled Trial

Mediterranean Diet and Physical Activity Nudges versus Usual Care in Women with Rheumatoid Arthritis: Results from the MADEIRA Randomized Controlled Trial

Gut Dysbiosis and Dietary Interventions in Rheumatoid Arthritis—A Narrative Review

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