The relationship between microRNAs and Rab family GTPases in human cancers

Shahabi, Arman; Naghili, Behrooz; Ansarin, Khalil; Zarghami, Nosratollah

doi:10.1002/jcp.28038

Cited by 13 publications

(11 citation statements)

References 135 publications

(184 reference statements)

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“…MicroRNAs (miRNAs) are small (20-23 nucleotides) noncoding RNAs that are conserved evolutionarily [1] Currently, over 28,000 identified mature miRNAs do not encode proteins, but they can regulate gene expression of approximately 30% of biological proteins [2]. These epigenetic molecules regulate the expression of various genes that are involved in critical physiological processes, including differentiation, proliferation, and apoptosis by binding to the 3 -untranslated region region (3'-UTR) of a mRNA molecule [3]. f MiRNAs indicate a new perspective in the study of cancers.…”

Section: Introductionmentioning

confidence: 99%

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MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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MicroRNAs (miRNAs) are small and non-coding RNAs that display aberrant expression in the tissue and plasma of cancer patients when tested in comparison to healthy individuals. In past decades, research data proposed that miRNAs could be diagnostic and prognostic biomarkers in cancer patients. It has been confirmed that miRNAs can act either as oncogenes by silencing tumor inhibitors or as tumor suppressors by targeting oncoproteins. MiR-144s are located in the chromosomal region 17q11.2, which is subject to significant damage in many types of cancers. In this review, we assess the involvement of miR-144s in several cancer types by illustrating the possible target genes that are related to each cancer, and we also briefly describe the clinical applications of miR-144s as a diagnostic and prognostic tool in cancers.Int. J. Mol. Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers. More than 50% of miRNA genes were discovered to be located within the genomic regions that are involved in cancers, suggesting their role in human cancer pathogenesis. In pathological conditions, MiRNAs can negatively regulate gene expression and they are associated with tumor growth, apoptosis, invasion, and metastasis. In the past, several studies have indicated the ability of miRNAs in the inhibition of tumors as a critical option for the improvement of cancer therapy [4,5]. Tumor activator miRNAs, called oncomiRs, are overexpressed in various cancers. On the contrary, suppressive tumor miRNAs are underexpressed [6][7][8]. Among several miRNAs assessed, miR-144s seem to have a role in several cancers. These miRNAs are located in the chromosomal region 17q11.2, being significantly destroyed in many types of cancers. The predicted stem-loop structure of miR-144s recognized by the miRBase (http://mirbase.org/) is shown in Figure 1A. The miR-144 hairpin gives rise to the "guide strand" miR-144-5p and the sister "passenger" strand miR-144-3p ( Figure 1B).

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Section: Introductionmentioning

confidence: 99%

“…Sci. 2020, 21, 2578 2 of 23 of a mRNA molecule [3]. MiRNAs indicate a new perspective in the study of cancers.…”

mentioning

confidence: 99%

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Kooshkaki

Rezaei

Rahmati

et al. 2020

IJMS

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“…Previous studies have demonstrated that Rab family and the related signalling pathways have been used as therapeutic targets for the treatment of cancers . Increasing evidence has reported that miRNA/Rab interactions play a crucial role in the pathogenesis of cancer, the interaction is considered as potential therapeutics for cancer therapy . Rab10 is one of the multiple Rab isoforms that are implicated in the development of cancers.…”

Section: Discussionmentioning

confidence: 99%

Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA‐422a/Rab10 axis

Zhi²,

Zhao³

et al. 2020

Clin Exp Pharma Physio

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Esophageal squamous cell carcinoma (ESCC) is a major type of esophageal cancer, accounting for about 90% of cases. Circular RNA UBAP2 (circUBAP2) is involved in the progression of several types of cancers. However, the role of circUBAP2 in ESCC remains unclear. In the present study, circUBAP2 expression was found to be upregulated in ESCC tumour tissues. Knockdown of circUBAP2 through infection with lentiviral vector encoding shRNA targeting circUBAP2 (sh-circUBAP2) inhibited the proliferation, migration and invasion of ESCC cells. In addition, circUBAP2 significantly promoted the proliferation, migration and invasion of ESCC cells. In vivo xenograft assay demonstrated that circUBAP2 downregulation suppressed the tumour growth of ESCC. Further mechanism investigations proved that circUBAP2 exerted its role via sponging microRNA (miR)-422a, and miR-422a directly targeted Rab10 in ESCC cells. These findings suggested that circUBAP2 acted as oncogene through regulating the miR-422a/Rab10 axis in ESCC. K E Y W O R D ScircUBAP2, esophageal squamous cell carcinoma (ESCC), miR-422a, oncogene, Rab10

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“…Recent studies have reported that the reduction of some miRNAs was found to be related to higher levels of (Shahabi et al, 2019;Yan et al, 2019). First, to ascertain the miRNAs targeting Rab25, we excavated target genes through two bioinformatics databases (miRDB and Target Scan) and provided a list of miRNAs targeting Rab25.…”

Section: Correlation Between Let-7d and Mir-185 And Rab25 In Bc Tissuesmentioning

confidence: 99%

Let-7d and miR-185 Impede Epithelial-Mesenchymal Transition by Downregulating Rab25 in Breast Cancer

Shahabi

Naghili

Ansarin

et al. 2021

Asian Pac J Cancer Prev

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Despite the noticeable progress in the diagnosis of the early BC stage, most of the patients diagnosed with BC (~90%) die as a result of metastasis (Hosseini et al., 2016). Metastasis occurs through multi-step processes such as local invasion, migration, transport, and colonization (Montazeri et al., 2017;Mellatyar et al., 2018). One of the crucial factors for metastatic dissemination of cancer is a developmental process termed epithelial-mesenchymal transition (EMT) (Brabletz et al., 2018;Bahmanpour et al., 2019). EMT is a phenomenon in which cells lose their epithelial features and exhibit the migratory phenotype of mesenchymal cells (Aiello et al., 2018;Mittal, 2018). Snail, a master EMT-transcription factor, plays essential roles in multiple stages of embryonic development and

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The relationship between microRNAs and Rab family GTPases in human cancers

Cited by 13 publications

References 135 publications

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

MiR-144: A New Possible Therapeutic Target and Diagnostic/Prognostic Tool in Cancers

Knockdown of circular RNA UBAP2 inhibits the malignant behaviours of esophageal squamous cell carcinoma by microRNA‐422a/Rab10 axis

Let-7d and miR-185 Impede Epithelial-Mesenchymal Transition by Downregulating Rab25 in Breast Cancer

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