The Relationship Between Milk Fatty Acid Profile and Expression Levels of Scd, Fasn and Srebpf1 Genes in Damascus Dairy Goats

Özkan, Hüseyin; Yakan, Akın

doi:10.30607/kvj.728554

Cited by 2 publications

(2 citation statements)

References 31 publications

(47 reference statements)

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“…Antioxidant status of colostrum is important for maternal physiology and offspring health 35 . COX-2 and NRF2 are the most related genes with the oxidative status of tissues and biological liquids and have tended to be upregulation in response to immunological activity 36,37 . It has been reported that NRF2 increases by triggering TLR2 in leukocytes and oxidative stress may decrease by overexpressing TLR2 in goats 38 .…”

Section: Resultsmentioning

confidence: 99%

Expression Patterns of Major Genes in Fatty Acid Synthesis, Inflammation and Oxidative Stress Related Pathways and Quality Parameters During the Transition From Colostrum to Milk in Dairy Goats

Yakan¹,

Özkan²,

Çamdeviren³

et al. 2020

Preprint

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Colostrum is quietly different from mature milk. The molecular regulation of milk secretion and quality in the transition period from colostrum to milk in goats is largely unknown. The present study, mammary gland secretion of goats was collected in 0th, 4th, 7th, 14th and 28th days after parturition. In addition to composition and fatty acid profile of colostrum or milk, FASN, SCD, ACACA, COX-2, NRF2, TLR2, NF-kB, LTF and PTX3 genes expression patterns were determined from milk somatic cells. While somatic cell count (SCC), malondialdehyde (MDA), fat, fat-free dry matter (FFDM), protein and lactose were highest as expression levels of the oxidative and inflammatory genes (P<0.05), freezing point and electrical conductivity were lowest in colostrum. With the continuation of lactation, most of the fatty acids, n3 ratio, and odour index had increased, on the other hand, C14:0 and C16:0 had decreased. In addition, FASN was upregulated almost 3 folds in 14th day (P<0.05). While SCD was similar, ACACA was upregulated more than 5 folds in 7th and 14th days (P<0.05). Furthermore, significant correlations were determined between studied genes. Although colostrum is important for offspring health in terms of inflammation and oxidative stress related pathways, further studies are needed on complex molecular pathways including fatty acid synthesis on goat mammary gland.

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Section: Resultsmentioning

confidence: 99%

Expression Patterns of Major Genes in Fatty Acid Synthesis, Inflammation and Oxidative Stress Related Pathways and Quality Parameters During the Transition From Colostrum to Milk in Dairy Goats

Yakan¹,

Özkan²,

Çamdeviren³

et al. 2020

Preprint

Self Cite

View full text Add to dashboard Cite

show abstract

“…Antioxidant status of colostrum is important for maternal physiology and offspring health 44 . COX-2 and NRF2 are the most related genes with the oxidative status of tissues and biological liquids and have tended to be upregulation in response to immunological activity 45 , 46 . It has been reported that NRF2 increases by triggering TLR2 in leukocytes and oxidative stress may decrease by overexpressing TLR2 in goats 47 .…”

Section: Discussionmentioning

confidence: 99%

Expression patterns of major genes in fatty acid synthesis, inflammation, oxidative stress pathways from colostrum to milk in Damascus goats

Yakan

Özkan

Çamdeviren

et al. 2021

Sci Rep

Self Cite

View full text Add to dashboard Cite

The molecular regulation of milk secretion and quality in the transition period from colostrum to milk in goats is largely unknown. In the present study, mammary gland secretion of goats was collected in 0th, 4th, 7th, 14th and 28th days after parturition. In addition to composition and fatty acid profile of colostrum or milk, FASN, SCD, ACACA, COX-2, NRF2, TLR2, NF-kB, LTF and PTX3 genes expression patterns were determined from milk somatic cells. While somatic cell count (SCC), malondialdehyde (MDA), fat, fat-free dry matter, protein and lactose were highest as expression levels of the oxidative and inflammatory genes, freezing point and electrical conductivity were lowest in colostrum. With the continuation of lactation, most of the fatty acids, n3 ratio, and odour index increased but C14:0 and C16:0 decreased. While FASN was upregulated almost threefolds in 14th day, ACACA was upregulated more than fivefolds in 7th and 14th days. Separately, the major genes in fatty acid synthesis, inflammation and oxidative stress were significantly associated with each other due to being positively correlated. MDA was positively correlated with SCC and some of the genes related inflammation and oxidative stress. Furthermore, significant negative correlations were determined between SCC and fatty acid synthesis related genes. With this study, transition period of mammary secretion was particularly clarified at the molecular levels in Damascus goats.

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The Relationship Between Milk Fatty Acid Profile and Expression Levels of Scd, Fasn and Srebpf1 Genes in Damascus Dairy Goats

Cited by 2 publications

References 31 publications

Expression Patterns of Major Genes in Fatty Acid Synthesis, Inflammation and Oxidative Stress Related Pathways and Quality Parameters During the Transition From Colostrum to Milk in Dairy Goats

Expression Patterns of Major Genes in Fatty Acid Synthesis, Inflammation and Oxidative Stress Related Pathways and Quality Parameters During the Transition From Colostrum to Milk in Dairy Goats

Expression patterns of major genes in fatty acid synthesis, inflammation, oxidative stress pathways from colostrum to milk in Damascus goats

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