The Relationship Between Mitral Annular Calcification, Metabolic Syndrome and Thromboembolic Risk

Aksoy, Fatih; Güler, Serdar; Kahraman, Fatih; Kuyumcu, Mevlüt Serdar; Bağcı, Ali; Baş, Hasan Aydın; Uysal, Dinçer; Varol, Ercan

doi:10.21470/1678-9741-2019-0062

Cited by 12 publications

(9 citation statements)

References 25 publications

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“…In patients with MAC, doctors should inaugurate AF preventative measures and reduce adverse outcomes and associated burden if AF is evident. We observed that AF was more common in patients with MAC, consistent with left atrial dilatation 36,37 . MAC patients susceptible to AF may require rhythm control strategies, while patients with complicated AF may require more rigorous anticoagulation regimens.…”

Section: Discussionmentioning

confidence: 56%

Noncontrast cardiac computed tomography‐derived mitral annular calcification scores in mitral valve disease

Hou

Sun

Wang

et al. 2023

Clinical Cardiology

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Background and AimsMitral annular calcification (MAC) by computed tomography (CT) is reported as an independent predictor of poor outcomes. However, it currently remains unclear if quantitative MAC parameters provide more value for mitral valve disease (MVD) management, therefore, we examined the prognostic value of MAC scores using noncontrast cardiac‐CT in MVD patients.MethodsBetween January 2020 and December 2021, we prospectively enrolled 300 consecutive patients with MVD (MAC‐present = 80 and MAC‐absent = 220) undergoing preoperative cardiac‐CT and mitral valve (MV) surgery. Noncontrast cardiac‐CT images were used to qualitatively detect MAC (present or absent) and evaluate MAC scores. For analyses, we also collected baseline clinical data, intraoperative conversion (from MV repair to MV replacement), and follow‐up arrhythmia data.ResultsCompared with the MAC‐absent group, MAC‐present patients were older (62 ± 7 vs. 58 ± 9 years, p < .001), mostly women (55% vs. 39.5%, p = .017), and also had aortic valve calcification (57.5% vs. 23.2%, p < .001), mitral stenosis (82.5% vs. 61.8%, p < .001), atrial fibrillation (30% vs. 11.8%, p < .001), and larger left atrial end‐diastolic dimension (LADD, 49 [44–56] versus 46 [41–50], p = .001]. Furthermore, MAC‐present patients underwent more MV replacements (61.8% vs. 82.5%, p = .001) and experienced a higher intraoperative conversion prevalence (11.8% vs. 61.3%, p < .001). Multiple logistic regression analyses showed that the female gender (odds ratio [OR]/95% confidence interval [CI]/p = 2.001/1.042–3.841/0.037) and MAC scores (OR/95% CI/p = 10.153/4.434–23.253/p < .001) were independent predictors of intraoperative conversion. During a follow‐up of 263 ± 134 days, MAC‐present patients had more arrhythmias (42.5% vs. 9.5%, p < .001). Also, MAC‐scores (hazard ratio [HR]/95% CI/p = 6.841/3.322–14.089/p < .001) and LADD (HR/95% CI/p = 1.039/1.018–1.060/p < .001) were independently associated with arrhythmias by Cox regression analyses.ConclusionsNoncontrast cardiac CT‐derived MAC‐scores showed a high risk for intraoperative conversion and follow‐up arrhythmias in MVD‐patients.

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Section: Discussionmentioning

confidence: 56%

Noncontrast cardiac computed tomography‐derived mitral annular calcification scores in mitral valve disease

Hou

Sun

Wang

et al. 2023

Clinical Cardiology

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“…It has been previously reported that the presence of structural diseases such as mitral annular calcification and an increase in epicardial adipose tissue were associated with high CHA 2 DS 2 -VASc scores 9,10 . Additionally, the same studies also showed that echocardiographic left ventricular measurements were associated with high CHA 2 DS 2 -VASc scores.…”

Section: Discussionmentioning

confidence: 97%

A Simple Risk Scoring Systems to evaluate the presence of aneurysm and one-year mortality in patients with abdominal aortic aneurysm using CHA2DS2-VASc and ATRIA

Aksoy

Uysal

2021

Rev. Assoc. Med. Bras.

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OBJECTIVE:We aimed to demonstrate the clinical utility of CHA 2 DS 2 -VASc and anticoagulation and risk factors in atrial fibrillation risk scores in the assessment of one year mortality in patients with abdominal aortic aneurysm. METHODS:We designed a retrospective cohort study using data from Suleyman Demirel University Hospital for the diagnosis of abdominal aortic aneurysm. The study included 120 patients with abdominal aortic aneurysm who underwent aortic computed tomography.Patients were divided into two groups according to presence of abdominal aortic aneurysm and the development of mortality. Predictors of mortality were determined by multiple logistic regression analysis.RESULTS: Multivariate regression analysis showed that CHA 2 DS 2 -VASc score, advanced age, female gender and elevated white blood cell counts were independent predictors of abdominal aortic aneurysm development while CHA 2 DS 2 -VASc score and elevated glucose levels were independent predictors of one year mortality in patients with abdominal aortic aneurysm. The concordance statistics for anticoagulation and risk factors in atrial fibrillation risk Score and CHA 2 DS 2 -VASc risk score respectively were 0.96 and 0.97 and could significantly predict one year mortality in patients with abdominal aortic aneurysm (p<0.001, and p<0.001, respectively).CONCLUSIONS: CHA 2 DS 2 -VASc and anticoagulation and risk factors in atrial fibrillation risk scores are easily obtained in an emergency setting and can accurately predict one year mortality as a noninvasive follow-up in patients with abdominal aortic aneurysm. These simple scores could be used as a point of care decision aid to help the clinician in counseling patients presenting with abdominal aortic aneurysm and their families on treatment protocols.

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“…Parallel results were attained by Chua et al [ 12 ] , based on a prospective study including 277 patients undergoing CABG and/or valve procedures. Moreover, we showed that CHA 2 DS 2 -VASC score have been predicting AF following ST-elevation myocardial infarction and associated with epicardial fat tissue and mitral annular calcification [ 13 - 15 ] . The data of the current study corroborate with the results of previous studies.…”

Section: Discussionmentioning

confidence: 99%

The Validation of the ATRIA and CHA2DS2-Vasc Scores in Predicting Atrial Fibrillation after Coronary Artery Bypass Surgery

Uysal

Aksoy

İbrişim

2020

Braz J Cardiovasc Surg

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Objective The aim of this study was to evaluate the value of CHA 2 DS 2 -VASc and Anticoagulation and Risk Factors in Atrial Fibrillation (ATRIA) risk scores for prediction of postoperative atrial fibrillation (AF) development in patients undergoing coronary artery bypass grafting (CABG) operation. Methods The population of this observational study consisted of 370 patients undergoing CABG operation. CHA 2 DS 2 -VASc and ATRIA risk scores were calculated for all patients and their association with postoperative AF (AF episode lasting > 5 min) were evaluated. Predictors of postoperative AF were determined by multiple logistic regression analysis. Results During follow-up, 110 patients (29.7%) developed postoperative AF. With multiple logistic regression analysis, risk factors for postoperative AF were determined: ATRIA risk score (odds ratio [OR] 1.23; 95% confidence interval [CI] 1.11-1.36; P <0.001), fasting glucose level (OR 1.006; 95% CI 1.004-1.009; P <0.001), and 24-hour drainage amount (OR 1.002; 95% CI; 1.001-1.004; P <0.001). Receiver operating characteristic curve analyses showed that CHA 2 DS 2 -VASc and ATRIA risk scores were signiﬁcant predictors for new-onset AF (C-statistic 0.648; 95% CI 0.59-0.69; P <0.001; and C-statistic 0.664; 95% CI 0.61-0.71; P<0.001, respectively). Conclusion CHA 2 DS 2 -VASc and ATRIA risk scores predict new AF in patients undergoing CABG.

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The Relationship Between Mitral Annular Calcification, Metabolic Syndrome and Thromboembolic Risk

Cited by 12 publications

References 25 publications

Noncontrast cardiac computed tomography‐derived mitral annular calcification scores in mitral valve disease

Noncontrast cardiac computed tomography‐derived mitral annular calcification scores in mitral valve disease

A Simple Risk Scoring Systems to evaluate the presence of aneurysm and one-year mortality in patients with abdominal aortic aneurysm using CHA2DS2-VASc and ATRIA

The Validation of the ATRIA and CHA2DS2-Vasc Scores in Predicting Atrial Fibrillation after Coronary Artery Bypass Surgery

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