The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

Mărginean, Cristina Oana; Bănescu, Claudia; Meliţ, Lorena Elena; Tripon, Florin; Iancu, Mihaela

doi:10.1038/s41390-019-0347-2

Cited by 18 publications

(20 citation statements)

References 36 publications

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“…New blood vessels formed from preexisting cell connections through mitosis, sprouting, proliferation, and migration of ECs and growth of new capillaries (Longchamp et al, 2018; Nowak-Sliwinska et al, 2018; Zhang et al, 2018). Matrix metallopeptidase 9 enhances tissue remodeling by degrading the extracellular matrix and plays an important role in angiogenesis (Mărginean et al, 2019). Vascular endothelial growth factor promotes EC migration, proliferation, and vessel formation by acting on ECs and combining with the cell-surface tyrosine kinase receptor VEGFR2, initiating an orchestrated cascade of signal transduction via the PI3K and MAPK pathways (Longchamp et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Bao

Alyafeai

et al. 2019

Front. Pharmacol.

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Random-pattern skin flap replantation is commonly used to repair skin defects during plastic and reconstructive surgery. However, flap necrosis due to ischemia and ischemia–reperfusion injury limits clinical applications. Betulinic acid, a plant-derived pentacyclic triterpene, may facilitate flap survival. In the present study, the effects of betulinic acid on flap survival and the underlying mechanisms were assessed. Fifty-four mice with a dorsal random flap model were randomly divided into the control, betulinic acid group, and the betulinic acid + 3-methyladenine group. These groups were treated with dimethyl sulfoxide, betulinic acid, and betulinic acid plus 3-methyladenine, respectively. Flap tissues were acquired on postoperative day 7 to assess angiogenesis, apoptosis, oxidative stress, and autophagy. Betulinic acid promoted survival of the skin flap area, reduced tissue edema, and enhanced the number of microvessels. It also enhanced angiogenesis, attenuated apoptosis, alleviated oxidative stress, and activated autophagy. However, its effects on flap viability and angiogenesis, apoptosis, and oxidative stress were reversed by the autophagy inhibitor 3-methyladenine. Our findings reveal that betulinic acid improves survival of random-pattern skin flaps by promoting angiogenesis, dampening apoptosis, and alleviating oxidative stress, which mediates activation of autophagy.

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Section: Discussionmentioning

confidence: 99%

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Bao

Alyafeai

et al. 2019

Front. Pharmacol.

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“…8 Previous studies by our team showed that, in Romanian women, the prevalence of pregnant women with excessive GWG has also increased during recent years. 14 , 33 , 34 …”

Section: Discussionmentioning

confidence: 99%

“…Short-term complications of excessive GWG include gestational diabetes, gestational arterial hypertension 4 , 9 , 10 that should be differentiated by other conditions, 11 an increased risk of cesarean section delivery, 12 and neonatal complications, such previously giving birth to a macrosomic neonate or other life-threatening conditions. 13 – 16 Long-term consequences of excessive GWG include maternal weight retention and excessive neonatal adiposity, which eventually lead to a continuous increase in the obesity rate in the general population. 17 – 19 Excessive GWG is difficult to be reduced after delivery, resulting in maternal adiposity and weight retention.…”

Section: Introductionmentioning

confidence: 99%

Relationships between excessive gestational weight gain and energy and macronutrient intake in pregnant women

et al. 2020

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Objective This study aimed to compare energy and macronutrient intake, birth weight, and anthropometric parameters (mid-upper arm circumference or tricipital skin-fold thickness) between women who had adequate and excessive gestational weight gain (GWG) during pregnancy. Methods We studied 115 pregnant women and divided them according to GWG into two groups: adequate GWG (n = 49) and excessive GWG (n = 66). We assessed the medical history, clinical examinations, and dietary habits through a detailed 7-day dietary recall using myfitnesspal software. Results Weight, body mass index, mid-upper arm circumference, and tricipital skin-fold thickness were significantly higher at the time of delivery in women with excessive GWG compared with those with adequate GWG. A lipid-based diet was a risk factor for excessive GWG (relative risk: 1.488, 95% confidence interval: 1.112–1.991), whereas a protein-based diet was a protective factor (relative risk: 0.6723, 95% confidence interval: 0.4431–1.020). We found no significant relationship between a carbohydrate-based diet and GWG. The total energy intake was significantly higher in the excessive GWG group than in the adequate GWG group. Conclusions Mainly a lipid-based diet in pregnant women might represent a risk factor for excessive GWG. However, a protein-based diet is a protective factor for excessive GWG.

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“…Several studies underlined the role of genetic determinism in the development of obesity or DM, pre-pregnancy weight, GWG, and postpartum persistence weight gain. [13,41–43] It was proved that the T allele of GNB3 rs5443 SNP is associated with obesity, atherosclerosis, hypertension, or DM, [27–29] while other alleles were not found to be related with this disorders. [31,32,44] The contradictory results were most likely due to the small number of cases, ethnicity or assessed genes.…”

Section: Discussionmentioning

confidence: 99%

“…Among these, matrix metalloproteinase (MMP) gene polymorphisms like MMP9 rs17577, MMP9 rs17576, and alfa 2 adrenergic receptor rs553668 single nucleotide polymorphism (SNP) are involved in birth weight determinism. [13] Moreover, the studies performed on obese children and healthy controls proved that gene polymorphisms of interleukin 6, leptin receptor, tumor necrosis factor alpha own a major role in the development of childhood obesity. [14–17]…”

Section: Introductionmentioning

confidence: 99%

The relationship among GNB3 rs5443, PNPLA3 rs738409, GCKR rs780094 gene polymorphisms, type of maternal gestational weight gain and neonatal outcomes (STROBE-compliant article)

Mărginean¹,

Bănescu

Meliţ

et al. 2019

Medicine

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The gestational weight gain is determined by food habits, environmental and genetic factors. The aims of this paper were to establish relationships between maternal gene polymorphisms (patatin-like phospholipase domain-containing protein 3 rs738409 [ PNPLA3 rs738409], glucokinase regulatory protein rs780094 [ GCKR rs780094], and guanine nucleotide-binding protein rs5443 [ GNB3 rs5443]) and mothers’ gestational weight gain, but also neonatal outcomes (birth weight, length, and ponderal index [PI]). We performed a cross-sectional study in a sample of 158 mothers and their product of conception’ in an Obstetrics-Gynecology Clinic from Romania. We divided the pregnant women according to the Institute of Medicine recommendations into 3 subgroups: (1) insufficient gestational weight gain; (2) normal gestational weight gain; and (3) excessive gestational weight gain. The gestational weight gain among pregnant women included in this study was classified as insufficient (10.1%), normal (31%), and excessive (58.9%). We found a tendency towards statistical significance for mothers that were overweight or obese before pregnancy to present an excessive gestational weight gain as compared to the normal weight ones. Similarly, we identified a tendency for statistical significance regarding the association between the variant genotype of GNB3 rs5443 and excessive gestational weight gain. We noticed differences that tended to be statistical significant concerning aspartate aminotransferase values between the 3 subgroups, mothers with excessive gestational weight gain having higher values than mothers with normal gestational weight gain (median, IQR: 22.89[17.53; 31.59] for mothers with excessive gestational weight gain versus 22.71[18.58; 27.37] for mothers with normal gestational weight gain). In mothers with excessive gestational weight gain, we found a significant association between the variant genotype of PNPLA3 rs738409 polymorphism and neonatal PI noticing a decrease of this index in case of newborns from mothers carrying the variant genotype. Excessive gestational weight gain was noticed in pregnant women that were obese and overweight before pregnancy. We found a positive association between the variant genotype of GNB3 rs5443 polymorphism and excessive gestational weight gain. Similarly, the presence of variant genotype of PNPLA3 rs738409 in mothers was associated with a lower PI in their newborns. Our study pointed out the most important factors that influence gestational weight gain and related birth outcomes.

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The relationship between MMP9 and ADRA2A gene polymorphisms and mothers–newborns’ nutritional status: an exploratory path model (STROBE compliant article)

Cited by 18 publications

References 36 publications

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Betulinic Acid Enhances the Viability of Random-Pattern Skin Flaps by Activating Autophagy

Relationships between excessive gestational weight gain and energy and macronutrient intake in pregnant women

The relationship among GNB3 rs5443, PNPLA3 rs738409, GCKR rs780094 gene polymorphisms, type of maternal gestational weight gain and neonatal outcomes (STROBE-compliant article)

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