The relationship between oxidative stress and cytogenetic abnormalities in B-cell chronic lymphocytic leukemia

Жевак, Т. Н.; Shelekhova, Tatiana; Чеснокова, Н. П.; Царева, О. Е.; CHANTURIDZE, A.V.; Litvitsky, P.F.; Andriutsa, Natalia; Samburova, N. A.; Budnik, Ivan

doi:10.1016/j.yexmp.2020.104524

Cited by 8 publications

(10 citation statements)

References 51 publications

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“…Several other metabolic fluxes, most notably the pentose phosphate pathway and mitochondrial metabolism, are emerging as important for cancer in maintaining redox balance, in addition to the extensively studied glycolytic metabolism. [27].The results in figure (1)(2)(3) are in agree with several recently studies , Zhevak et al ., indicated that patients with B-CLL experience increased oxidative stress (OS) by concomitantly increasing reactive oxygen metabolites production and the relative deficiency of the antioxidant defence system [28]. and also agree with Bakan et al, they demonstrated increasing MDA levels in the plasma of CLL patients, which may not only be the result of increased production but also a failure of the antioxidant defence [29].…”

Section: Discussionsupporting

confidence: 69%

“…[32,33]. The decreased antioxidant capacity found in the sera of our B-CLL patients may be related to a consumption of antioxidants and/or to a reduced efficacy of antioxidant defences due to the systemic excess of ROS that is common in cancer [34].Accumulating evidence by two important studies suggested that increased OS and the relative deficiency of the antioxidant defence system are involved in crucial steps of B-CLL development [28,35]. Resultantly, it may be involved in initiation and enhancement of multiple stage carcinogenesis, cell apoptosis , proliferation, differentiation, and immune function suppression, and it contributes to genomic DNA, RNA instability that resulted in gene mutations through cell division, and a final result is development of B-CLL [36][37][38].…”

Section: Discussionmentioning

confidence: 89%

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Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Saleem¹,

Awad²,

Alwan³

2022

ijhs

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Due to the importance of increasing the incidence conditions of B cell chronic lymphocytic leukemia (B-CLL) that requiring accurate knowledge of the biology behind the pathogenesis and risks of this disease of each individual patient, this study was designed to investigate if hormonal alterations such as Hepcidin, Erythropoietin, and oxidant-antioxidant status may be useful in the understanding of B-CLL development in addition the relationship of these parameters with anemia in advance clinical stage in newly diagnosed patients with B-CLL. This study was conducted on 60 newly diagnosed patients with B-CLL and 30 control group .The socio-demographic information including (age and sex) and clinical data were collected for the period from 20 February until 25 December 2021. The result of the present study showed that out of the 60 newly diagnosed B-CLL patients, 39 was male and 21 was females, with the mean age ( 64.04 ± 5.6 ) years and out of the 30 controls group ,12 was males and 18 was females with the mean age of ( 63.33 ± 4.70) years .therefore, it was a higher prevalence p value ≤0.05 of newly diagnosed B-CLL patients in males (65.0 %) compare to females (35.0 % ).

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Section: Discussionsupporting

confidence: 69%

Section: Discussionmentioning

confidence: 89%

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Saleem¹,

Awad²,

Alwan³

2022

ijhs

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“…CP is a multi-function glycoprotein and has been reported to play crucial roles in various pathological conditions, such as Wilson disease, inflammation, fibrosis, and neurodegenerative disorders (16)(17)(18). In addition to its role in non-malignant diseases, CP is a well-known tumor (19)(20)(21)(22)(23). Furthermore, high CP mRNA levels are associated with malignant potential in esophageal cancer, bile duct cancer, renal cell carcinoma, and adrenocortical carcinoma (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Pathological Features and Outcome in Bladder Cancer

et al. 2021

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Background/Aim: Α previous report showed that immune complex-ceruloplasmin (CP) in urine is associated with carcinogenesis and malignant behavior in bladder cancer (BC). We investigated the pathological significance and prognostic roles of urine and tissue levels of CP protein in BC patients. Materials and Methods: Urine CP levels were measured using an enzyme-linked immunosorbent assay in 97 patients. CP expression in BC tissues was evaluated by immunohistochemical analysis in 176 patient samples. Results: Urine CP levels were positively associated with tumor grade and pT stage in non-muscle invasive BC (NMIBC). CP expression in BC tissues was positively associated with tumor growth and progression. Multivariate analysis demonstrated that high urine CP levels was an independent predictor of recurrence in the urinary tract in NMIBC (hazard ratio=2.87, p=0.016). Conclusion: CPrelated markers, especially urine CP levels, are useful biomarkers of malignant potential and prognosis in NMIBC.

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“…In addition, MDA is one of the end products of lipid peroxidation in the body, which can promote the occurrence and development of tumors. In tumor and vascular diseases, the MDA levels are significantly increased ( Zińczuk et al, 2019 ; Cerdá-Bernad et al, 2020 ; Zhevak et al, 2020 ). Our results also showed that the MDA levels in serum and liver tissue of the DEN group were significantly upregulated, and febuxostat reversed the upregulation of MDA to the level of the healthy control group.…”

Section: Discussionmentioning

confidence: 99%

Elevated Serum Uric Acid is Associated With Poor Survival in Advanced HCC Patients and Febuxostat Improves Prognosis in HCC Rats

Yang

et al. 2021

Front. Pharmacol.

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Objective: Serum uric acid is associated with tumor progression and hepatocarcinogenesis. Here, we aimed to determine whether serum uric acid is related to the survival time of patients with hepatocellular carcinoma (HCC) and whether the inhibition of uric acid production affects the progression and survival of rats with HCC.Methods: The follow-up data of 288 patients with advanced HCC were analyzed. Ten purine metabolites in serum and liver samples of diethylnitrosamine (DEN)-induced HCC rats were quantitatively determined by an established UPLC-MS/MS method. On this basis, febuxostat, a specific inhibitor of xanthine oxidase (XOD), was used to interfere with HCC rats.Results: The serum uric acid level of HCC patients was significantly negatively correlated with survival days (r = -0.155). The median survival time was 133.5 days in the high uric acid group (>360 μmol/L, n = 80) and 176.0 days in the normal serum uric acid group (<360 μmol/L, n = 208, p = 0.0013). The levels of hypoxanthine, guanine, and uric acid; XOD activity; and xanthine dehydrogenase mRNA expression in the serum or liver samples of HCC rats were significantly upregulated compared with those in the control group. After febuxostat intervention in DEN-induced HCC rats, the number of atypical cells and inflammatory cells decreased significantly; the serum alpha fetoprotein level and Fisher’s ratio tended to return to normal; the median survival time increased from 36 to 96 days (p = 0.08). In addition, serum malondialdehyde, superoxide dismutase, and glutathione activity nearly returned to the level of the healthy control group.Conclusion: The elevation of serum uric acid implies a risk of poor survival in advanced HCC patients and Febuxostat can reduce the generation of reactive oxygen species, thereby playing a role in delaying the progression of liver cancer.

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The relationship between oxidative stress and cytogenetic abnormalities in B-cell chronic lymphocytic leukemia

Cited by 8 publications

References 51 publications

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Risk factors for iron metabolic disorders in newly diagnosed B-chronic lymphocytic leukemia patients

Ceruloplasmin Levels in Cancer Tissues and Urine Are Significant Biomarkers of Pathological Features and Outcome in Bladder Cancer

Elevated Serum Uric Acid is Associated With Poor Survival in Advanced HCC Patients and Febuxostat Improves Prognosis in HCC Rats

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