The Relationship Between Padi4 -94G/A Polymorphism and Rheumatoid Arthritis: A Meta-analysis in Multi Ethnic Groups

Abstract

Background: A number of studies have reported the association between peptidylarginine deiminase 4 (PADI4) -94G/A polymorphisms and rheumatoid arthritis (RA) risk in different populations, however, the results remained inconclusive. Objecitve: We therefore aim to address this association by performed an updated meta-analysis in multi ethnic groups. Methods: The PubMed and Chinese related databases were searched up to January 2019. The strength of association between PADI -94G/A polymorphism and RA susceptibility was assessed with odds ratios (ORs) and 95% confidence intervals (CIs). Results: A total of 22 studies with 14514 RA cases and 21138 controls were finally included in the analysis. Six ethnic groups such as China, Japan, USA, UK, Sweden and Spain were contained. In the overall population, it revealed that PADI -94G/A polymorphism was significantly associated with an increased risk of RA. In the subgroup analyses by ethnicity, significant association was found in China as well as in Japan and USA. Conclusions: This meta-analysis demonstrates that the PADI4 -94G/A polymorphisms may represent a significant risk factor for RA in China, in Japan and USA. Further studies are needed to clarify this finding, since most available studies were conducted among Chinese and Japanese in this study.

Polymorphism of protein tyrosine phosphatase non‐receptor type 22 and protein arginine deiminase 4 gene among Ghanaian rheumatoid arthritis patients: A case–control study

“…The role PAD4 plays in the pathogenesis of RA prompted researchers to investigate its association with the susceptibility of RA 18,19 . Jian et al in 2021 demonstrated a lack of association between PAD4 and RA susceptibility and severity in a UK population 18 . This finding was in agreement with the results of this study, where an association could not be made between PAD4 (rs220340) and RA susceptibility (Table 3).…”

“…In a study by Jian et al, PTPN22 (rs2476601) showed an association with RA in a UK population but failed to show an association among Africans. 18 This indicates the heterogenicity that exists across different populations. This outcome was similar to this study, where an association could not be made between PTPN22…”

“…PAD4 (rs2240340) is a gene with a strong association with RA, especially among Asians 17 . The role PAD4 plays in the pathogenesis of RA prompted researchers to investigate its association with the susceptibility of RA 18,19 . Jian et al in 2021 demonstrated a lack of association between PAD4 and RA susceptibility and severity in a UK population 18 .…”