The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese

Furugen, Reiko; Hayashida, Hideaki; Yamaguchi, Noboru; Yoshihara, Akihiro; Ogawa, Hiroshi; Miyazaki, Hideo; Saito, Toshiyuki

doi:10.1111/j.1600-0765.2008.01085.x

Cited by 88 publications

(104 citation statements)

References 31 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…IL-6 promotes osteoclast differentiation. 16 Furugen et al 23 found no significant difference in serum IL-6 levels in individuals with and without periodontitis, while higher levels have also been reported in periodontitis. 24 There is research showing that IL-6 inhibits adiponectin gene expression and secretion in 3T3-L1 adipocytes, indicating that it is implicated in adiponectin regulation.…”

Section: Discussionmentioning

confidence: 99%

“…9 There are studies 23,27,28 that have not shown statistically significant differences in serum adiponectin levels in periodontitis patients compared with healthy control individuals, while a recent article 29 showed a lower ratio of high-molecular-weight adiponectin to total adiponectin in patients with periodontal pockets; this ratio was independently associated with periodontal condition.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

et al. 2012

View full text Add to dashboard Cite

The aim of the study was to compare the serum levels of adiponectin and interleukin-6 (IL-6) in insulin-treated diabetic rats with or without periodontitis. Forty male Wistar rats were randomly divided into 2 groups (20 rats each): a) insulin-treated diabetic group (control, DI) and b) insulin-treated diabetic periodontitis group (test, DIP). Diabetes was induced, and insulin treatment was initiated on day 5. On day 16, periodontitis was induced in the DIP group. All rats were euthanized on day 77. Adiponectin and IL-6 were assessed on days 16 and 77. At the end of the experiment, 14 and 11 rats survived in the DI and DIP groups, respectively. Adiponectin levels were statistically significantly higher at the end of the experiment compared with levels on day 16 in the periodontitis group (p < 0.05), but not in the control group. At the end of the experiment, adiponectin levels were statistically significantly higher in the periodontitis group compared with the control group (p < 0.05). Within-group and between-group comparisons of IL-6 levels showed no statistically significant difference. In conclusion, serum adiponectin was increased in insulin-treated diabetic rats with periodontitis in comparison with insulin-treated diabetic rats, while IL-6 levels did not differ between groups.

show abstract

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

et al. 2012

View full text Add to dashboard Cite

show abstract

“…On the other hand, Shimada et al (18) found a positive correlation between leptin levels and the following clinical parameters: PD, CAL, bone loss and BMI, which sustain the inflammatory role of this adipokine. Furugen et al (16) found a positive correlation between BOP and resistin, which indicates its presence in inflammation. They found a significant but weak negative correlation between adiponectin levels and CAL; this result the authors credited to the low levels of adiponectin observed in males with severe clinical attachment loss.…”

Section: Discussionmentioning

confidence: 99%

Serum Adipokine Levels and their Relationship with Fatty Acids in Patients with Chronic Periodontitis

et al. 2015

View full text Add to dashboard Cite

Adipokines are present in inflammatory processes and may be directly related to periodontal disease. Moreover, their activities may be regulated by fatty acids. The goal of this study was to quantify the concentrations of the main adipokines, leptin, adiponectin and resistin, and the docosahexaenoic (DHA), docosapentaenoic (DPA), eicosapentaenoic (EPA) and arachidonic (AA) fatty acids, in patients with generalized chronic periodontitis. As a secondary objective, the ratios of these substances in the blood of these patients were evaluated. The study included 15 systemically healthy patients with generalized chronic periodontitis (test group) and 15 patients with gingivitis (control group). Medical and periodontal parameters and blood samples were collected. Serum concentrations of fatty acids were analyzed by gas chromatography and adipokines by multiplex bead immunoassay. There was no significant difference in adipokines between groups. However, there was a tendency for lower values of adiponectin in periodontitis patients. Regarding the fatty acids, they were significantly higher in the test group compared with controls. The res/DHA, res/AA, adipon/DHA, adipon/AA and adipon/DPA ratios were significantly lower in the test group. There was no significant correlation between adipokines and clinical parameters and between adipokines and fatty acids levels. It was concluded that generalized chronic periodontitis patients showed significantly higher levels of fatty acids in comparison to gingivitis; adiponectin revealed a trend to lower values in the periodontitis group, even after Ancova correction. The ratios suggest a minor proportion of adiponectin and resistin in relation to the fatty acids in patients with generalized chronic periodontitis.

show abstract

“…33 Son 10 yılda resistin seviyesinin KP, T2DM ve obezite ile ilişkisini değerlendiren birçok çalışma yapılmıştır [34][35][36][37][38][39][40][41] (Tablo 1). Bunların bir kısmında, sadece KP'si olan bireylerde; 34,35 bazılarında ise KP'ye ilave olarak T2DM 36,38 veya obezite 37,39,41 varlığında resistin seviyeleri araştırılmıştır. Çalışmaların çoğunda sistemik olarak sağlıklı KP hastalarında serum resistin seviyesinin periodontal olarak sağlıklı bireylere kıyasla daha yüksek olduğu bildirilmiştir.…”

Section: Resim 1 Periodontitis Tip 2 Diabetes Mellitus Ve Insülin Dunclassified

Role of resistin in chronic periodontitis

Kalkan¹,

Dogan²

2018

Yeditepe J Dent

View full text Add to dashboard Cite

The relationship between periodontal condition and serum levels of resistin and adiponectin in elderly Japanese

Abstract: Background and Objective: Diabetes and periodontitis are associated with each other.

Cited by 88 publications

References 31 publications

Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

Adiponectin and interleukin-6 levels in insulin-treated diabetic rats with experimental periodontitis

Serum Adipokine Levels and their Relationship with Fatty Acids in Patients with Chronic Periodontitis

Role of resistin in chronic periodontitis

Contact Info

Product

Resources

About