The relationship between physical activity level and cardiovascular disease biomarkers in healthy, normal-weight 3- to 6-year-old children and their parents

Abstract

To determine if physical activity is linked to cardiovascular biomarkers in preschool children at risk, we need information on these biomarkers in healthy normal weight children. In this population, multi-level modeling analyses found no correlation between accelerometer recorded physical activity and fasting lipids, adiponectin, or insulin sensitivity. Exploratory analyses found positive correlations between adiponectin and time spend in light physical activity, and between triglyceride and time spent in sedentary behavior, findings to be confirmed in longitudinal prospective studies.

Relationships between sedentary behaviour, physical activity levelsand red blood cell distribution width in children and adolescents

“…It is well known that prolonged sedentary behavior (SB) and reduced physical activity (PA) are risk factors for CVD and major contributors to CVD mortality. 10 - 12 There are several possible biological mechanisms by which increased PA contributes to reducing CVD risk including improved body composition, enhanced lipid metabolism, 13 reduced blood pressure (BP) 14 and reduced systemic inflammation. 15 Specifically, C-reactive protein (CRP), a protein associated with chronic inflammation, is a strong predictor of CVD risk that can be decreased with increased PA and reduced SB.…”