The Relationship between Plasma ADAMTS 7 Level and Left Ventricular Remodeling after Acute Myocardial Infarction

Abstract

Background: Left Ventricular (LV) dysfunction is the single strongest predictor of mortality following ST elevation myocardial infarction and is one of the most frequent and deadly complications of non ST elevation myocardial infarction. Degradation of Extracellular Matrix (ECM) causes progressive thinning and dilatation of infarct zone and contributes to serious complication as ventricular dilatation, dysfunction, aneurysm and even rupture. The matrix metalloproteinase-mediated degradation and remodeling of ECM plays an essential role in these disease processes.Aim of the Study: It was to evaluate the relationship between plasma ADAMTS 7 level and left ventricular remodeling after acute myocardial infarction.Results: There was statistically significant increase in ADAMTS 7 concentration in group II (patients with ejection fraction <40) as compared with both group I (patients with ejection fraction >_40) and group III (controls), while there was no statistically significant difference between group I and group III. There was a statistically significant negative correlation between ADAMTS 7 concentration and both ejection fraction and fractional shortening in acute myocardial infarction patients. While there was a statistically significant positive correlation between ADAMTS 7 concentration and both left ventricular end diastolic diameter and left ventricular end systolic diameter in acute myocardial infarction patients. Conclusion:The results of this research showed that there was a significant increase in the mean value of ADAMTS 7 levels in patients with ejection fraction <40% than in patients with ejection fraction >_40%, so it may be used as a strong predictor for the development of left ventricular remodeling after acute myocardial infarction and this may be of a great value as a therapeutic target.