The relationship between plasma microRNAs and serum trace elements levels in primary hyperlipidemia

Yerlikaya, Fatma Hümeyra; Can, Unal; Alpaydın, Mehmet Sertaç; Arıbaş, Alpay

doi:10.4149/bll_2019_056

Cited by 8 publications

(9 citation statements)

References 25 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is quite certain that many new glycosylation disorders are awaiting their identifi cation since it is estimated that more than 500 genes, approximately 0.5 to 1% of the translated human genome, participate in oligosaccharide synthesis and function. For that reason, defects in glycosylation pathway need to be considered more often as the cause of these disorders and physicians need to be aware of them, know their limitations and appropriate way of management (19). Furthermore, the development of animal models offers the potential to test therapeutic approaches and will be helpful in understanding the pathogenesis of these disorders (6).…”

Section: Resultsmentioning

confidence: 99%

Congenital disorders of glycosylation – an umbrella term for rapidly expanding group of rare genetic metabolic disorders – importance of physical investigation

Lekka¹,

Brucknerová²,

Šalingová³

et al. 2021

BLL

View full text Add to dashboard Cite

AIM: Congenital disorders of glycosylation (CDG) belong to an expanding group of rare genetic metabolic disorders caused by defects in the complex chemical enzymatic process of glycosylation. The study is aimed at presenting a case report of a premature dysmorphic newborn, clinical presentation of the condition, the way it was diagnosed and treated, as well as its comparison with the known cases. RESULTS: The result of glycan analysis supports the assumption of a supposed glycosylation disorder and also specifi es a specifi c subtype: CDG-1, subtype ALG12-CDG (Ig). CONCLUSION: CDG have an extremely wide clinical spectrum and should be considered in any child with unexplained developmental delay, failure to thrive, seizures, and abnormalities in liver enzymes, coagulation and immunologic factors. The treatment of most forms of CDG depends upon numerous factors such as specifi c symptoms present, severity of the disorder, age and overall health of the patients and tolerance to certain medications or procedures. For these reasons, the treatment is specifi c for every individual. It is based on the symptoms and requires a coordination of efforts of a team of specialists (Tab. 4, Fig. 3, Ref. 19).

show abstract

Section: Resultsmentioning

confidence: 99%

Congenital disorders of glycosylation – an umbrella term for rapidly expanding group of rare genetic metabolic disorders – importance of physical investigation

Lekka¹,

Brucknerová²,

Šalingová³

et al. 2021

BLL

View full text Add to dashboard Cite

show abstract

“…Obesity-associated exosomal miRNAs are important in the pathogenic mechanism of glucose intolerance and dyslipidemia [16]. Overexpression of miR-27a-3p may cause obesity and dyslipidemia [17]. Overexpression of miR-107 may regulate the insulin signaling pathway and cause the imbalance of glucose homeostasis [18].…”

Section: Expression and Role Of Pdk4 On Childhood Dyslipidemia And Li...mentioning

confidence: 99%

Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice

Cai,

Wang,

Deng

et al. 2023

Horm Metab Res

View full text Add to dashboard Cite

Hyperlipidemia is a common metabolic disorder that can lead to cardiovascular disease. PDK4 is a key enzyme that regulates glucose and fatty acid metabolism and homeostasis. The aim of this study is to explore the correlation between PDK4 expression and dyslipidemia in obese children, and to find new therapeutic targets for hyperlipidemia in children. The expression of PDK4 in serum was detected by qRT-PCR. Receiver operating characteristic curve was used to analyze the relationship between PDK4 and dyslipidemia. Upstream miRNAs of PDK4 were predicted by the database and verified by dual luciferase reporter gene assay and detected by qRT-PCR. The hyperlipidemia mouse model was established by high-fat diet (HFD) feeding, and the metabolic disorders of mice were detected. PDK4 is poorly expressed in the serum of obese children. The upstream of PDK4 may be inhibited by miR-107, miR-27a-3p, and miR-106b-5p, which are highly expressed in the serum of obese children. Overexpression of PDK4 improves lipid metabolism in HFD mice. miR-27a-3p silencing upregulates PDK4 to improve lipid metabolism. In conclusion, PDK4 has a diagnostic effect on dyslipidemia in children, while lipid metabolism in hyperlipidemic mice could be mitigated by upregulation of PDK4, which was inhibited by miR-107, miR-27a-3p and miR-106b-5p on upstream.

show abstract

“…In the last decade, very few ionomics studies have been conducted for hyperlipidemia patients. Yerlikaya et al found that lower levels of essential elements (Cr, Fe, Mn, Mo, and Se) as well as higher levels of Co, Ni, and Cd in serum are associated with an increased risk of primary hyperlipidemia, suggesting an important role of these elements in the regulation of lipid homeostasis ( 224 ). On the other hand, several studies have either confirmed previous observations or revealed additional elements that are associated with hyperlipidemia.…”

Section: Recent Progress In Ionomics Of Metabolic Diseasesmentioning

confidence: 99%

Recent advances in the application of ionomics in metabolic diseases

et al. 2023

View full text Add to dashboard Cite

Trace elements and minerals play a significant role in human health and diseases. In recent years, ionomics has been rapidly and widely applied to explore the distribution, regulation, and crosstalk of different elements in various physiological and pathological processes. On the basis of multi-elemental analytical techniques and bioinformatics methods, it is possible to elucidate the relationship between the metabolism and homeostasis of diverse elements and common diseases. The current review aims to provide an overview of recent advances in the application of ionomics in metabolic disease research. We mainly focuses on the studies about ionomic or multi-elemental profiling of different biological samples for several major types of metabolic diseases, such as diabetes mellitus, obesity, and metabolic syndrome, which reveal distinct and dynamic patterns of ion contents and their potential benefits in the detection and prognosis of these illnesses. Accumulation of copper, selenium, and environmental toxic metals as well as deficiency of zinc and magnesium appear to be the most significant risk factors for the majority of metabolic diseases, suggesting that imbalance of these elements may be involved in the pathogenesis of these diseases. Moreover, each type of metabolic diseases has shown a relatively unique distribution of ions in biofluids and hair/nails from patients, which might serve as potential indicators for the respective disease. Overall, ionomics not only improves our understanding of the association between elemental dyshomeostasis and the development of metabolic disease but also assists in the identification of new potential diagnostic and prognostic markers in translational medicine.

show abstract

The relationship between plasma microRNAs and serum trace elements levels in primary hyperlipidemia

Cited by 8 publications

References 25 publications

Congenital disorders of glycosylation – an umbrella term for rapidly expanding group of rare genetic metabolic disorders – importance of physical investigation

Congenital disorders of glycosylation – an umbrella term for rapidly expanding group of rare genetic metabolic disorders – importance of physical investigation

Expression and Role of PDK4 on Childhood Dyslipidemia and Lipid Metabolism in Hyperlipidemic Mice

Recent advances in the application of ionomics in metabolic diseases

Contact Info

Product

Resources

About