2020
DOI: 10.1177/0960327120925891
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The relationship between PNP, GSTO-1, AS3MT and ADRB3 gene polymorphisms and urinary arsenic concentration among copper smelter and refinery employers

Abstract: Introduction: The aim of this study was to assess the relationship between polymorphisms of genes encoding enzymes involved in arsenic metabolism and urinary arsenic concentration in people occupationally exposed to arsenic. Materials and Methods: The data from 113 employers directly exposed to lead, cadmium, and arsenic in copper smelter in Legnica and Glogow were collected. Urinary arsenic concentration was measured. In addition, blood level of cadmium, lead, and zinc protoporphyrins was assayed. Genetic ana… Show more

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(1 citation statement)
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“…ARR has been detected in arsenic-contaminated soil and organisms expressing ARR can promote the reduction of dissolved arsenate [ 7 ]. The absorption and metabolism of arsenic depends on the polymorphism of the gene encoding purine nucleoside phosphorylase (PNP) [ 8 ]. In addition, nicotinamide adenine dinucleotide (NAD), as one of the coenzymes of glycolysis metabolism, greatly enhances the reduction of As 5+ [ 9 ].…”
Section: Introductionmentioning
confidence: 99%
“…ARR has been detected in arsenic-contaminated soil and organisms expressing ARR can promote the reduction of dissolved arsenate [ 7 ]. The absorption and metabolism of arsenic depends on the polymorphism of the gene encoding purine nucleoside phosphorylase (PNP) [ 8 ]. In addition, nicotinamide adenine dinucleotide (NAD), as one of the coenzymes of glycolysis metabolism, greatly enhances the reduction of As 5+ [ 9 ].…”
Section: Introductionmentioning
confidence: 99%