2010
DOI: 10.1507/endocrj.k10e-015
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The relationship between Receptor Activator of Nuclear Factor-.KAPPA.B Ligand (RANKL) gene polymorphism and aortic calcification in Korean women

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Cited by 20 publications
(20 citation statements)
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“…Similar to previous studies [33,34], in the present work, no significant differences were observed in the circulating levels of OPG, sRANKL, or the sRANKL/OPG ratio and the genotypes of OPG, RANKL, RANK SNPs. Although the balance between OPG and RANKL play an important role in osteoclast activity and bone resorption, the regulation of OPG, RANKL, and RANK expression depends on a variety of factors such as cytokines, glucocorticoid, growth factors, and hormones [35].…”
Section: Discussionsupporting
confidence: 91%
“…Similar to previous studies [33,34], in the present work, no significant differences were observed in the circulating levels of OPG, sRANKL, or the sRANKL/OPG ratio and the genotypes of OPG, RANKL, RANK SNPs. Although the balance between OPG and RANKL play an important role in osteoclast activity and bone resorption, the regulation of OPG, RANKL, and RANK expression depends on a variety of factors such as cytokines, glucocorticoid, growth factors, and hormones [35].…”
Section: Discussionsupporting
confidence: 91%
“…On the contrary, RANKL polymorphisms showed an association with aortic calcification. 48 Several limitations of our study need to be addressed. Whether OPG is causally related with advanced AAA disease remains unclear from this study.…”
Section: Discussionmentioning
confidence: 96%
“…Genetic variants in the OPG locus have previously been implicated with osteoporotic fracture [38], bone turnover [39], bone mineral density [40], osteonecrosis [41], diabetic neuroarthropathy [42] as well as ankylosing spondylitis [43]. Alterations at the RANK locus and/or functionally related genes, such as RANKL , have also been reported to be associated with rheumatoid arthritis [30], aortic calcification [44], bone mineral density [39] and Paget's disease of bone [31]. Recently, emerging evidence has indicated an association between OPG / RANK / RANKL gene polymorphisms with carcinogenesis.…”
Section: Discussionmentioning
confidence: 99%