The Relationship between Selected Inflammation and Oxidative Stress Biomarkers and Carotid Intima-Media Thickness (IMT) Value in Youth with Type 1 Diabetes Co-Existing with Early Microvascular Complications

Peczyńska, Joanna; Klonowska, Bożenna; Żelazowska-Rutkowska, Beata; Polkowska, Agnieszka; Noiszewska, Klaudyna; Bossowski, Artur; Głowińska‐Olszewska, Barbara

doi:10.3390/jcm11164732

Cited by 4 publications

(3 citation statements)

References 73 publications

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“…The literature also describes the important role of systemic inflammation and oxidative stress in the pathogenesis of atherosclerosis. In a recent study of patients with type 1 diabetes, hsCRP and myeloperoxidase were useful biomarkers for assessing the risk of carotid atherosclerosis [18]. They could also be considered as potential makers of disease progression despite optimal medical treatment and traditional risk factor control, which in turn is associated with an increased risk of adverse cardiovascular events [19].…”

Section: Discussionmentioning

confidence: 99%

The FCGR2A Is Associated with the Presence of Atherosclerotic Plaques in the Carotid Arteries—A Case-Control Study

Szpakowicz,

Szum-Jakubowska,

Lisowska

et al. 2023

JCM

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Background. Atherosclerotic plaques in carotid arteries (APCA) are a prevalent condition with severe potential complications. Studies continuously search for innovative biomarkers for APCA, including those participating in cellular metabolic processes, cell adhesion, immune response, and complement activation. This study aimed to assess the relationship between APCA presence and a broad range of cardiometabolic biomarkers in the general population. Methods. The study group consisted of consecutive participants of the population study Bialystok PLUS. The proximity extension assay (PEA) technique from the Olink Laboratory (Uppsala, Sweden) was used to measure the levels of 92 cardiometabolic biomarkers. Results. The study comprised 693 participants (mean age 48.78 ± 15.27 years, 43.4% males, N = 301). APCA was identified in 46.2% of the participants (N = 320). Of the 92 biomarkers that were investigated, 54 were found to be significantly linked to the diagnosis of APCA. After adjusting for the traditional risk factors for atherosclerosis in multivariate analysis, the only biomarker that remained significantly associated with APCA was FCGR2A. Conclusion. In the general population, the prevalence of APCA is very high. A range of biomarkers are linked with APCA. Nonetheless, the majority of these associations are explained by traditional risk factors for atherosclerosis. The only biomarker that was independently associated with APCA was the FCGR2A.

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Section: Discussionmentioning

confidence: 99%

The FCGR2A Is Associated with the Presence of Atherosclerotic Plaques in the Carotid Arteries—A Case-Control Study

Szpakowicz,

Szum-Jakubowska,

Lisowska

et al. 2023

JCM

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“…The optimal point for early intervention would be during the identification of intima-media complex thickening or the presence of early plaques [127][128][129]. Increasing thickness of the carotid intima-media complex and carotid plaques is related to the extent and severity of atherosclerosis, in addition to polyvascular atherosclerosis [163][164][165][166][167][168][169][170][171]. Also, the role of mi-croRNAs in cardiovascular risk factor modification seems extremely important.…”

Section: Future Directions and Conclusionmentioning

confidence: 99%

Cardiac microRNAs: diagnostic and therapeutic potential

Kabłak-Ziembicka,

Badacz,

Okarski

et al. 2023

Arch Med Sci

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MicroRNAs are small non-coding post-translational biomolecules which, when expressed, modify their target genes. It is estimated that microRNAs regulate production of approximately 60% of all human proteins and enzymes that are responsible for major physiological processes. In cardiovascular disease pathophysiology, there are several cells that produce microRNAs, including endothelial cells, vascular smooth muscle cells, macrophages, platelets, and cardiomyocytes. There is a constant crosstalk between microRNAs derived from various cell sources. Atherosclerosis initiation and progression are driven by many pro-inflammatory and pro-thrombotic microRNAs. Atherosclerotic plaque rupture is the leading cause of cardiovascular death resulting from acute coronary syndrome (ACS) and leads to cardiac remodeling and fibrosis following ACS. MicroRNAs are powerful modulators of plaque progression and transformation into a vulnerable state, which can eventually lead to plaque rupture. There is a growing body of evidence which demonstrates that following ACS, microRNAs might inhibit fibroblast proliferation and scarring, as well as harmful apoptosis of cardiomyocytes, and stimulate fibroblast reprogramming into induced cardiac progenitor cells. In this review, we focus on the role of cardiomyocyte-derived and cardiac fibroblast-derived microRNAs that are involved in the regulation of genes associated with cardiomyocyte and fibroblast function and in atherosclerosis-related cardiac ischemia. Understanding their mechanisms may lead to the development of microRNA cocktails that can potentially be used in regenerative cardiology.

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“…The first caution that should attract the attention of clinicians is CIMT [ 103 , 104 , 105 ]. CIMT, in ranges above the 75th percentile for age and gender, can even be observed in teenagers and young adults, particularly if accompanied by atherosclerosis risk factors, such as diabetes or familial hypercholesterolemia [ 106 , 107 ]. This parameter is well correlated with risk of cardiovascular events, such as cardiovascular death (CVD), IS, and myocardial infarction (MI) [ 103 , 104 , 105 ].…”

Section: From Fatty Streaks and Foam Cells To Mature Plaquementioning

confidence: 99%

microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

Badacz

Przewłocki

Legutko

et al. 2022

IJMS

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Ischemic stroke (IS) related to atherosclerosis of large arteries is one of the leading causes of mortality and disability in developed countries. Atherosclerotic internal carotid artery stenosis (ICAS) contributes to 20% of all cerebral ischemia cases. Nowadays, atherosclerosis prevention and treatment measures aim at controlling the atherosclerosis risk factors, or at the interventional (surgical or endovascular) management of mature occlusive lesions. There is a definite lack of the established circulating biomarkers which, once modulated, could prevent development of atherosclerosis, and consequently prevent the carotid-artery-related IS. Recent studies emphasize that microRNA (miRNA) are the emerging particles that could potentially play a pivotal role in this approach. There are some research studies on the association between the expression of small non-coding microRNAs with a carotid plaque development and vulnerability. However, the data remain inconsistent. In addition, all major studies on carotid atherosclerotic plaque were conducted on cell culture or animal models; very few were conducted on humans, whereas the accumulating evidence demonstrates that it cannot be automatically extrapolated to processes in humans. Therefore, this paper aims to review the current knowledge on how miRNA participate in the process of carotid plaque formation and rupture, as well as stroke occurrence. We discuss potential target miRNA that could be used as a prognostic or therapeutic tool.

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The Relationship between Selected Inflammation and Oxidative Stress Biomarkers and Carotid Intima-Media Thickness (IMT) Value in Youth with Type 1 Diabetes Co-Existing with Early Microvascular Complications

Cited by 4 publications

References 73 publications

The FCGR2A Is Associated with the Presence of Atherosclerotic Plaques in the Carotid Arteries—A Case-Control Study

The FCGR2A Is Associated with the Presence of Atherosclerotic Plaques in the Carotid Arteries—A Case-Control Study

Cardiac microRNAs: diagnostic and therapeutic potential

microRNAs Associated with Carotid Plaque Development and Vulnerability: The Clinician’s Perspective

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