The relationship between sensitivity to pain and conditioned pain modulation in healthy people

Grouper, Hadas; Eisenberg, Elon; Pud, Dorit

doi:10.1016/j.neulet.2019.134333

Cited by 13 publications

(20 citation statements)

References 34 publications

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“…A previous intermittent analysis revealed findings related to the role of the endogenous pain inhibition systems in determining sensitivity to pain in these groups. 39 The only similarity between both manuscripts relates to the approach by which the two groups were distinguished from each other in their sensitivity to pain. The method of classifying the two distinct groups according to cold pain tolerance is based on our previous observations 39 , 40 and on several other reports.…”

Section: Methodsmentioning

confidence: 99%

“…39 The only similarity between both manuscripts relates to the approach by which the two groups were distinguished from each other in their sensitivity to pain. The method of classifying the two distinct groups according to cold pain tolerance is based on our previous observations 39,40 and on several other reports. [41][42][43][44] Accordingly, healthy subjects typically demonstrate a large variability in enduring the CPT.…”

Section: Methodsmentioning

confidence: 99%

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More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

Grouper¹,

Eisenberg²,

Pud³

2021

JPR

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Purpose The present study aimed to assess the influence of personality traits on the variability of sensitivity to pain in two distinct groups of healthy subjects with low versus high sensitivity to pain (LSP vs HSP, respectively). Methods Healthy subjects (n=156) were allocated to two groups according to their tolerability to cold stimulation (cold pressor test, CPT, 1°C). Group LSP (n=76) reached the cut-off time of 180±0 sec, and a size matched group of HSP (n=80) tolerated the CPT for an average of 10.5±3.4 sec only. Subjects from both groups completed the self-reported pain sensitivity questionnaire (PSQ), the Pain Catastrophizing Scale (PCS), and the Neuroticism Extraversion Openness - Five Factor Inventory (NEO-FFI). Results In comparison to the LSP group, HSP individuals had higher scores of PSQ ( p <0.001), catastrophizing ( p =0.001), and extraversion ( p =0.01). By adjusting for age and gender, mediation analyses revealed that catastrophizing mediated the relationship between neuroticism and pain sensitivity, both in the allocation of subjects to a certain group of sensitivity to pain (LSP or HSP, B=0.02 95% CI: 0.006–0.040) and in the PSQ score (B=0.01 95% CI: 0.001–0.023). Conclusion These results, which were demonstrated by two different prisms (CPT and PSQ), point to the potential of the five-factor inventory and pain catastrophizing scale as tools for identifying specific personality traits associated with a high sensitivity to pain.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

Grouper¹,

Eisenberg²,

Pud³

2021

JPR

Self Cite

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“…It has also previously been proposed that previous pain experience and pain threshold are variables that can influence pain modulation [19,46]. Therefore, in this study, we analyzed the influence of the variables self-perceived tolerance to pain and previous history of pain.…”

Section: Discussionmentioning

confidence: 98%

Conditioned Pain Modulation Effectiveness: An Experimental Study Comparing Test Paradigms and Analyzing Potential Predictors in a Healthy Population

Ibancos-Losada¹,

Osuna-Pérez

Castellote-Caballero

et al. 2020

Brain Sciences

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Conditioned pain modulation (CPM) is an endogenous pain inhibition phenomenon that can be summarized simply as one type of pain being able to inhibit another, which must be in a remote area in relation to the first pain. We aimed to compare the effectiveness of four CPM test paradigms as well as the association of the CPM effect with potential predictors in 72 healthy volunteers. Pressure pain from an algometer was used as the test stimulus, and pain provoked by cold water or ischemic pressure was used as the conditioning stimulus, applied either sequentially or in parallel. No significant differences were found between the test paradigms, although the cold-parallel test showed the most significant effect size (ηP2 = 0.614). No association was found between the CPM effect and sociodemographic variables (age or sex), nor anxiety, depression, catastrophizing, previous history of pain or self-perceived pain tolerance. Nevertheless, a strong association was found between the CPM effect and individual affinity for the stimulus in participants who underwent the cold water test paradigm; this explained around 45% of the total CPM effect when the paradigm (cold water) coincided with personal affinity for the stimulus (“I prefer cold to heat”, “cold is not unpleasant”).

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“…Only few studies targeted the described problem empirically. For instance, in the study conducted by Grouper et al [22], participants were tested using a conditioned pain modulation (CPM) paradigm, which  As an example, in recent systematic review of offset analgesia 12/26 included studies (46%) used fixed intensity while remained were based on calibration procedure.…”

Section: The Dilemmamentioning

confidence: 99%

To Calibrate or not to Calibrate? A Methodological Dilemma in Experimental Pain Research

Adamczyk¹,

Szikszay²,

Nahman‐Averbuch³

et al. 2022

The Journal of Pain

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The relationship between sensitivity to pain and conditioned pain modulation in healthy people

Cited by 13 publications

References 34 publications

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

More Insight on the Role of Personality Traits and Sensitivity to Experimental Pain

Conditioned Pain Modulation Effectiveness: An Experimental Study Comparing Test Paradigms and Analyzing Potential Predictors in a Healthy Population

To Calibrate or not to Calibrate? A Methodological Dilemma in Experimental Pain Research

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