The Relationship Between Serum 25(OH)D and Parathyroid Hormone Levels

Saliba, Walid; Barnett, Ofra; Rennert, Gad; Lavi, Idit; Rennert, Gad

doi:10.1016/j.amjmed.2011.07.009

Cited by 112 publications

(81 citation statements)

References 21 publications

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“…However, prolonged high levels of PTH can impair intestinal Ca absorption and stimulates osteoclasts to dissolve the mineralized collagen matrix in bone, causing many bone diseases (15) . Holick and co-workers (12) (62) . In obese individuals with low vitamin D status, secondary hyperparathyroidism and elevated serum PTH levels are also evident (63)(64)(65) .…”

Section: Discussionmentioning

confidence: 99%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

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Objective: To examine the vitamin D status, SNP of the vitamin D receptor gene (VDR) and the effects of vitamin D supplementation on parathyroid hormone and insulin secretion in adult males with obesity or normal weight in a subtropical Chinese city. Design: An intervention trial. Setting: Shenzhen City, Guangdong Province, China. Subjects: From a cross-sectional survey conducted from June to July, eighty-two normal-weight and ninety-nine obese males (18-69 years) were screened to analyse their vitamin D status and for five SNP of VDR. From these individuals, in the same season of a different year, obese and normal-weight male volunteers (twenty-one per group) were included for an intervention trial with oral vitamin D supplementation at 1250 µg/week for 8 weeks.Results: For the survey, there was no significant difference (P > 0·05) in baseline circulating 25-hydroxyvitamin D concentrations or in the percentages of participants in different categories of vitamin D status between the two groups. The VDR SNP, rs3782905, was significantly associated with obesity (P = 0·043), but none of the examined SNP were correlated with serum 25-hydroxyvitamin D when adjusted for age, BMI and study group. After vitamin D supplementation, serum 25-hydroxyvitamin D concentration, hypersecretions of parathyroid hormone and insulin, and insulin resistance in the obese were changed beneficially (P < 0·05); however, the increase in serum 25-hydroxyvitamin D was less than that of the normal-weight men. Conclusions: For obese and normal-weight men of subtropical China, the summer baseline vitamin D status was similar. However, oral vitamin D supplementation revealed a decreased bioavailability of vitamin D in obese men and ameliorated their hypersecretion of parathyroid hormone and insulin resistance. KeywordsVitamin D Obesity Chinese male Parathyroid hormone Insulin resistanceIn China, approximately 12 % of adult males are considered to be obese (1,2) . Since vitamin D nutritional status may be important in regulating obesity (3)(4)(5)(6) , interest was aroused to study Chinese obese males in this regard. Circulating 25-hydroxyvitamin D (25(OH)D; calcidiol), a metabolite of vitamin D having a half-life of 2-3 weeks, is recommended as a reliable marker of vitamin D nutritional status (7)(8)(9)(10) . The US Institute of Medicine (11) reports that a circulating 25(OH)D concentration equal to 50 nmol/l (20 ng/ml) meets the vitamin D requirements of 97·5 % of the population, and this threshold is widely accepted for hypovitaminosis D (10,(12)(13)(14) . Not satisfied with that basic requirement, many researchers claim that improvement of circulating 25(OH)D concentrations to much higher than 50 nmol/l can prevent a broad range of diseases (4,(15)(16)(17) .In addition, 25(OH)D ≤25 nmol/l (10 ng/ml) is considered to be 'severe vitamin D deficiency', 75-250 nmol/l (30-100 ng/ml) a 'sufficient or optimal' level and 50-75 nmol/l (21-29 ng/ml) an 'insufficient' level (12,13,18) , although these reference ranges are not defined by the Inst...

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Section: Discussionmentioning

confidence: 99%

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Zhou

Zhu²,

Chen³

et al. 2014

Public Health Nutr.

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“…An opposite trend has observed in PTH levels that is attributed to the seasonal change in 25-hydroxyvitamin D [16,17]. Few studies with small number of patients examined 25-hydroxyvitamin D seasonality in PHPT and reported conflicting results [6][7][8]12].…”

Section: Introductionmentioning

confidence: 89%

Seasonal changes in serum calcium, PTH and vitamin D levels in patients with primary hyperparathyroidism

Nevo-Shor

Kogan

Joshua

et al. 2016

Bone

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“…Данное сочета-ние симптомов возможно как при нормокальцие-мическом варианте ПГПТ, так и при недостаточно-сти витамина D, а также других состояниях [34][35][36]. В целях дифференциальной диагностики между нормокальциемическим вариантом первичного ги-перпаратиреоза и вторичным гиперпаратиреозом, возникшим в результате недостаточности витами-на D, необходимо проведение функциональных проб (табл.…”

Section: 6unclassified

Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment

Dedov

Иванович²,

Мельниченко

et al. 2017

Probl Endokrinol (Mosk)

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Primary hyperparathyroidism (PHT) is the third most common endocrine disorder in men and women after diabetes mellitus and thyroid disease and one of the most frequent causes of osteoporosis and fractures among the secondary osteopathy. PHT refers to socially significant problems in connection with involvement in the pathological process of the majority of organs and system In recent years, the conception of epidemiology, clinic and tactics of management of patients with PHT has changed due to significant increase of morbidity at the expense of identification of mild forms of disease. The modern management concept tactics depends on clinical manifestations. Bearing in mind the importance of the problem under consideration, the working group was set up for the development of federal recommendations on the treatment of PHT based on the principles of evidence-based medicine. The experience accumulated by the domestic and international experts was summarized in the federal clinical guidelines on PHT.

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The Relationship Between Serum 25(OH)D and Parathyroid Hormone Levels

Cited by 112 publications

References 21 publications

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Oral vitamin D supplementation has a lower bioavailability and reduces hypersecretion of parathyroid hormone and insulin resistance in obese Chinese males

Seasonal changes in serum calcium, PTH and vitamin D levels in patients with primary hyperparathyroidism

Primary hyperparathyroidism: the clinical picture, diagnostics, differential diagnostics, and methods of treatment

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