The relationship between serum apelin level and different grades of diabetic nephropathy in type 2 diabetic patients

Dawood, Alaa; Abdel-Raof, M; Ghobashy, Yasser El

doi:10.4103/2356-8062.205205

Cited by 7 publications

(5 citation statements)

References 6 publications

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“…In the present study, weight and BMI were significantly higher in DN group than control group and T1DM without DN. This is in agreement with study of Dawood et al (16) who found that BMI was significantly higher in DN groups compared with the control group. In disagreement with our study, Jabar (17) found that there was no significant difference concerning the body mass index between the patients (24.31 ± 0.54 kg/cm 2 ) and the control (26.18 ± 0.57 kg/cm 2 ).…”

Section: Discussionsupporting

confidence: 93%

Serum Level of Preptin in Children with Type-1 Diabetes Mellitus and Its Relation to Diabetic Nephropathy

Elsaeed¹,

Rahman²,

Sasi³

et al. 2021

The Egyptian Journal of Hospital Medicine

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Background: Type 1 diabetes is one of the most prevalent long-term diseases of childhood globally. Objective: This study aimed to evaluate a new biomarker such as preptin in patients with type 1 diabetes and to assess its relation to diabetic nephropathy. Patients and methods: This study was a case-control study that carried on 34 children and adolescents with type 1 diabetes mellitus in addition to 17 healthy children at the Pediatric Endocrinology Unit, Pediatric Department, Zagazig University Hospitals, from June 2020 to April 2021. All patients were subjected to laboratory investigations including fasting blood glucose levels, HbA1c, kidney function tests, lipid profile, serum albumin, urinary albumin, albumin creatinine ratio, glomerular filtration rate (GFR) and serum preptin. Results: This study showed that age, weight and BMI were significantly higher among group II with no significant difference between group I and II by LSD. Also, there was no significant difference among groups regarding gender or family history of DM. Conclusion:Serum preptin is significantly lower in patients with diabetic nephropathy compared with diabetic patients without nephropathy and healthy subjects.

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Section: Discussionsupporting

confidence: 93%

Serum Level of Preptin in Children with Type-1 Diabetes Mellitus and Its Relation to Diabetic Nephropathy

Elsaeed¹,

Rahman²,

Sasi³

et al. 2021

The Egyptian Journal of Hospital Medicine

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“…In the present study there were increases in ACRs in diabetic children in comparison to the healthy controls and there were positive correlations between APLN and chemerin blood levels with alp/creatinine ratio. Correlation of serum APLN with microalbuminuria was confirmed by another study by Guo et al,31 which reported that APLN and chemerin may induce glomerular endothelial cell proliferation and then nephropathy, also there was a negative correlation between serum APLN and GFR, which was stated in the study on type 2 diabetes 32. The cutoff point of APLN and chemerin was >126.45 and 92.18, respectively, with 100% sensitivity and specificity for APLN and 74%, 100% for chemerin in the prediction of nephropathy in diabetic children (Table 3, Figure 1).…”

Section: Discussionmentioning

confidence: 52%

“…Correlation of serum APLN with microalbuminuria was confirmed by another study by Guo et al, 31 which reported that APLN and chemerin may induce glomerular endothelial cell proliferation and then nephropathy, also there was a negative correlation between serum APLN and GFR, which was stated in the study on type 2 diabetes. 32 The cutoff point of APLN and chemerin was >126.45 and 92.18, respectively, with 100% sensitivity and specificity for APLN and 74%, 100% for chemerin in the prediction of nephropathy in diabetic children ( Table 3 , Figure 1 ). To our knowledge this is the first study to mention the cutoff for both markers in diabetic children.…”

Section: Discussionmentioning

confidence: 92%

<p>Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus</p>

Elsehmawy

El-Toukhy

Seliem

et al. 2019

DMSO

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BackgroundType 1 diabetes mellitus (T1DM) is one of the most common chronic diseases in children that may be due to micro or macrovascular complications. Diabetic renal disease or nephropathy is a common complication of DM, clinically silent and the only detectable abnormality due to the presence of microalbuminuria.Subjects and methodsThis study was a case–control study. Participants were classified into two groups. The first group included 40 children with T1DM and the second group included 30 matched healthy controls. Serum apelin (APLN), chemerin, cholesterol, and triglycerides (TG) levels were measured for each case. Also, albumin/creatinine ratio was analyzed in random urine sample.ResultsComparison between T1DM patients and controls revealed that serum apelin, chemerin, cholesterol, TG levels, and albuminuria were significantly increased in cases compared to their controls. Significant positive correlations were found between HbA1c% and albuminuria for APLN and chemerin in the diabetic group. Whereas significant negative correlations were found between apelin and glomerular filtration rate (GFR).ConclusionIncreased levels of serum apelin and chemerin in T1DM patients may be considered as promising adipokines for the development of diabetic complication.

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“…What is more, it has been observed that the inhibitory impact of histone acetylation prevents increasing kidney matrix size, lowers glomerular filtration rate, and decreases proteinuria. Numerous vascular problems in diabetics have been linked to this mechanism [28,29].…”

Section: Discussionmentioning

confidence: 99%

Correlation of apelin with microalbuminuria in type 2 diabetic patients

Shaik

Mahendran

Sheela

et al. 2023

Current Issues in Pharmacy and Medical Sciences

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Introduction. Type 2 diabetes mellitus is the root cause of diabetic nephropathy, a condition affecting the kidneys (T2DM). The number of people who have type 2 diabetes is growing. Aim. To evaluate the differences in Apelin 13 levels between patients with T2DM who had normal or microalbuminuria and those who had microalbuminuria, as well as between these patients and healthy controls. The intent is to better understand its link to microalbumin, haemoglobin A1c, insulin resistance (IR), and other standard measures. Materials and methods. Sixty individuals with type 2 diabetes, aged 35 to 45, were selected, and their microalbuminuria and normoalbuminuria were compared. Thirty age-matched healthy volunteers were selected to serve as controls. The concentrations of Apelin 13 and insulin in the plasma were measured with ELISA kits. The Turbilatex assay was used to calculate microalbumin concentrations. Measurements of glycosylated haemoglobin (HbA1C) were made via high-performance liquid chromatography. Results. Patients with type 2 diabetes mellitus had higher levels of the protein Apelin 13 in their plasma than did healthy controls. T2DM patients with microalbuminuria were different from normoalbuminuric patients in another important way. Correlations between plasma Apelin 13 and albuminuria, HbA1c, and HOMA-IR were all positive. Conclusion. Considering that plasma Apelin 13 is a critical risk factor in Type 2 diabetes mellitus and frequently arises in the early stages of nephropathy, it may be useful for the assessment of vascular issues in type 2 diabetic patients.

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The relationship between serum apelin level and different grades of diabetic nephropathy in type 2 diabetic patients

Cited by 7 publications

References 6 publications

Serum Level of Preptin in Children with Type-1 Diabetes Mellitus and Its Relation to Diabetic Nephropathy

Serum Level of Preptin in Children with Type-1 Diabetes Mellitus and Its Relation to Diabetic Nephropathy

<p>Apelin and chemerin as promising adipokines in children with type 1 diabetes mellitus</p>

Correlation of apelin with microalbuminuria in type 2 diabetic patients

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