The Relationship Between Serum Fetuin‐A, Cystatin‐C Levels, and Microalbuminuria in Patients With Metabolic Syndrome

Huddam, Bülent; Azak, Alper; Koçak, Gülay; Bayraktar, Nilüfer; Sezer, Sıren

doi:10.1002/jcla.21605

Cited by 15 publications

(10 citation statements)

References 31 publications

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“…In addition, a decline in the renal function of patients with diabetes was not always accompanied by an increased microalbuminuria . While considerable studies have been verified that the serum levels of cystatin C was positively correlated with microalbuminuria and eGFR in diabetic or metabolic syndrome patients . Our study results further confirmed that cystain C could be quite an ideal indicator that represents renal function in diabetic patients instead of serum creatinine.…”

Section: Discussionsupporting

confidence: 81%

Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta‐Analysis

et al. 2016

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This study aimed to evaluate the diagnostic value of serum cystatin C for renal dysfunction in diabetic patients. Eligible trials were searched from multiple databases, the data were extracted into a 2 × 2 table after the quality assessment of included articles. The pooled sensitivity, specificity and other parameters of accuracy of cystatin C were analyzed using Stata version 12.0. Seventeen studies involving 2173 patients were included. The pooled sensitivity and specificity of serum cystatin C for the diagnosis of renal dysfunction were 0.88 (95% CI: 0.83-0.91) and 0.87 (95% CI: 0.82-0.91), respectively. The positive likelihood ratio was 6.69 (95% CI: 4.83-9.26), negative likelihood ratio was 0.14 (95% CI: 0.10-0.20) and diagnostic odds ratio (DOR) was 46.57 (95% CI: 27.76-78.13). The area under the receiver operating characteristic curve was 0.94. Analysis of the 12 studies that investigated serum creatinine indicated that serum cystatin C was more accurate than serum creatinine for the diagnosis of renal dysfunction. Our results indicate that serum cystatin C is an effective index in diagnosing renal dysfunction comparing serum creatinine, serum cystatin C is more sensitivity for evaluation of renal function in diabetic patients.

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Section: Discussionsupporting

confidence: 81%

Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta‐Analysis

et al. 2016

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“…In contrast to some previous reports in non-T1D cohorts, fetuin A levels were not associated with dyslipidemia, any single lipid parameter [8, 9, 14, 55], or microalbuminuria [57]. The missing association with blood pressure has also been reported in nondiabetic adults [54].…”

Section: Discussioncontrasting

confidence: 51%

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

et al. 2017

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Background and Aim: The hepatokine fetuin A is upregulated in the metabolic syndrome and in type 2 diabetes (T2D), while its role in adolescent type 1 diabetes (T1D) is unclear. We assessed the relationship between circulating fetuin A levels and metabolic control, comorbidities, and complications in adolescent T1D patients. Methods: We studied the relationship between serum fetuin A and clinical diabetes-related data from the DPV registry (Diabetes-Patienten-Verlaufsdokumentation) in 172 adolescent T1D patients with early-onset (<5 years) long-standing (>10 years) T1D. Fetuin A levels were further compared between adolescent T1D and T2D patients. Results: Serum fetuin A levels in T1D patients (mean 0.267 ± 0.043 g/L) did not correlate with age, diabetes duration, gender, body mass index (BMI), glycated hemoglobin, serum lipid levels, blood pressure, celiac or thyroid disease, nephropathy, or retinopathy. An association of fetuin A levels with insulin requirements was only evident within the subgroup of overweight T1D patients (r_s = 0.439, p = 0.028, n = 25, BMI >90th percentile), disappearing after adjustment for multiple testing. Adolescent T1D patients showed distinctly lower fetuin A levels than patients with T2D (p ≤ 0.001). Conclusion: Overall, we did not observe a clinically relevant association of fetuin A levels with surrogate parameters for insulin sensitivity in our juvenile T1D cohort. A correlation with insulin requirements was detectable in overweight patients only. We hypothesize that multiple factors, such as obesity, puberty, inadequate metabolic control, and hepatic steatosis, have to add up before a clinically relevant effect of fetuin A on insulin sensitivity becomes evident.

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“…Bu çalışmalarda, nefroloji bilim dalında sık takip edilen böbrek hastalıkları ile yapılan on adet bilimsel yayının olması dikkat çekmekteydi (3)(4)(5)(6)(7)(8)(9)(10)(11)(12).…”

Section: Türk Nefroloji Diyaliz Ve Transplantasyon Dergisi Turkish Neunclassified

Scientific Publications Concerning Cystatin C: A Glimpse from Turkey

Ulu¹,

Polat²,

Ahsen³

et al. 2014

Turk Neph Dial Transpl

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ÖzSistatin C, sabit oluşum hızı olan, serum düzeyleri yaşa ve cinsiyete bağlı olarak değişiklik göstermeyen küçük molekül ağırlıklı bir proteindir. Glomerüllerden serbestçe filtre edilip, sekrete edilmez ve tübuler epitel hücrelerinde reabsorbe edilerek böbreklerden metabolize olur. Glomerül filtrasyon hızı için yeni bir marker olarak kullanılması söz konusudur. Son yıllarda sistatin C 'nin kullanıldığı çalışmaların sayısı ve ne kadarının nefroloji uzmanlarınca gerçekleştirildiği önem taşımaktadır. Makalemizde, dünyada ve Türkiye'de sistatin C kullanılarak gerçekleştirilen çalışmaların sayı ve konularının, yıllara göre dağılımlarının incelenmesi ve Türkiye'deki sistatin C kullanılarak yapılan çalışmaların değerlendirilmesi amaçlanmıştır.anahtaR SÖzcükleR: Sistatin C, Glomerül filtrasyon hızı, Nefroloji abStRact Cystatin C is a small molecular weight protein with a constant production rate and plasma levels that remain unchanged with age or gender. Cystatin C is filtered freely from the glomeruli and is not secreted; it is reabsorbable from the tubular epithelial cells and metabolized from the kidney rapidly. It is seen as a new marker for calculating the glomerular filtration rate. The number of studies in which cystatin C was used in recent years and the percentage that has been published by nephrology professionals is an important matter to consider. Our aim was to investigate the number of scientific studies using cystatin C from Turkey and the world, and the issues and publication details of the journals they appeared in by year, and to evaluate the use of cystatin C by nephrology experts in our country.

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The Relationship Between Serum Fetuin‐A, Cystatin‐C Levels, and Microalbuminuria in Patients With Metabolic Syndrome

Abstract: In our study, we found that MS patients with microalbuminuria had high levels of fetuin-A and cystatin-C. In conclusion, we suggest that determination of fetuin-A and cystatin C levels could be useful marker as an early indicator of renal injury in patients with MS.

Cited by 15 publications

References 31 publications

Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta‐Analysis

Diagnostic Accuracy of Serum Cystatin C for the Evaluation of Renal Dysfunction in Diabetic Patients: A Meta‐Analysis

Relationship of Serum Fetuin A with Metabolic and Clinical Parameters in German Children and Adolescents with Type 1 Diabetes

Scientific Publications Concerning Cystatin C: A Glimpse from Turkey

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