The Relationship between Serum Lipids and Breast Cancer in Libya

Jarari, AM

doi:10.4172/2161-1009.1000117

Cited by 23 publications

(26 citation statements)

References 22 publications

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“…Difference in results obtained in our study and previous research in breast cancer and alteration of lipid profile levels in patients may be due to the progression of the cancer and the side effect of chemotherapy, in addition to environmental, behavioral, and genetic differences [29].…”

Section: Discussioncontrasting

confidence: 98%

Alteration in Serum Lipid Profile Levels in Iraqi Women With Breast Cancer Before and After Chemotherapy

Hamoode

Al-Ani

2018

Asian J Pharm Clin Res

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Objective: Investigating the role of alterations in lipid profile in Iraqi women with breast cancer before and after chemotherapy.Methods: A total number of 100 patients aged 25-47 years were enrolled in this study, including 35 breast cancer treatment patients, 30 treatment patients, and 10 and 25 healthy women benefactor. All samples were collected from August 2016 to February 2017 from Oncology Hospital/Medical city in Baghdad; however, control group samples were collected from outside the hospital. Serum total cholesterol, serum triglyceride, and serum high-density lipoprotein cholesterol (HDL-C) were measured by spectrophotometer using a kit provided by Linear Chemicals. Results:The results show a highly significant increment (p˂0.01) in lipid profile in breast cancer, especially in diagnosis group as compared with other groups. Conclusion:The alteration in cholesterol, triglyceride, HDL-C, and very low-density lipoprotein is highly connected with breast cancer in Iraqi women, progression of disease and treatment effect.

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Section: Discussioncontrasting

confidence: 98%

Alteration in Serum Lipid Profile Levels in Iraqi Women With Breast Cancer Before and After Chemotherapy

Hamoode

Al-Ani

2018

Asian J Pharm Clin Res

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“…The previous studies conducted on breast cancer patients reported unchanged or slightly decreased HDLcholesterol level in breast cancer patients as compared to control group [9,20,21]. A few other studies reported significantly decreased HDL-cholesterol level in breast cancer patients [18,23,26].In contradict to our study; Peela et alfound significantly increased level of HDLcholesterol in breast cancer patients as compared to control [19]. Non-HDL cholesterol level in the present study was found to be increased in breast cancer patients as compared to control group.…”

Section: Discussioncontrasting

confidence: 95%

“…We found increased level of serum TC in both pre and postmenopausal breast cancer patients as compared to their respective control group. Our findings were in accordance to the several other studies [18][19][20][21].An increased level of TC was observed in breast cancer patients on chemotherapy as compared to control but the differences were not statistically significant [9,26].In contrast to our finding, a study by Timovska et al found decreased level of serum total cholesterol after two courses of neoadjuvant chemotherapy [22].In the present study, we observed decreased HDL-cholesterol level in breast cancer patient but the difference was statistically non significant as compared tocontrol group. The previous studies conducted on breast cancer patients reported unchanged or slightly decreased HDLcholesterol level in breast cancer patients as compared to control group [9,20,21].…”

Section: Discussionsupporting

confidence: 94%

Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy

Basnyat

Gyawali

Jha

et al. 2017

Ann. Clin. Chem. & Lab. Med.

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“…There are also the results of the study by Hu et al (36) who found that higher TCC increases the risk of breast cancer (OR=1.45; 95% CI: 1.14-1.85). Likewise, the study by Peela et al (37) found significantly increased TCC in patients with breast cancer. Llaverias et al (38) state that in general the role of cholesterol in the initiation and development of tumors is very controversial.…”

Section: Discussionmentioning

confidence: 82%

Hormonal contraception increases risk of breast tumor based on clinical breast examination among adult women

Darjoko¹,

Sapardin

2017

Universa Medicina

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Background In Indonesia, cancer prevalence according to the Basic Health Research 2013 was 1.4 per 1000 inhabitants and the most common cancer in hospitalized patients in 2010 was breast cancer (28.7%). Hormonal contraception (HC) use increases the breast cancer risk, even though HC has been used by 210 million women in the world. We aimed to define the association of HC with breast tumors based on clinical breast examination (CBE).Methods A case-control design using secondary data from the baseline of the Cohort Study on the Risk Factors of Non-Communicable Disease (RFNCD) in 2011-2012 in 5 villages in Central Bogor District, Bogor City. Samples consisted of 152 cases and 152 controls. Cases comprised palpable tumors in one or both breasts CBE (+). Controls had no tumors in both breasts /CBE(-). Data were analyzed by logistic regression.Results Odds Ratio (OR) of CBE + was 1.83 (95% CI: 1.11-3.04; p=0.019) for HC user and 1.62 (95% CI: 1.01-2.60; p=0.044) for blood total cholesterol level <200 mg/dL. OR of group CBE(+) was 1.01 (current smoking) and 0.49 (former smoking) compared with nonsmoking (p=0.082); OR was also 1.21 for subjects with one child and 1.77 for those without children, compared with those who had ³2 children (p=0.454).Conclusion Hormonal contraception use increases breast tumor risk 1.8-fold after controlling for total cholesterol, smoking status and parity. With the several limitations of this advanced analysis, investigations focused on types and duration of HC use are still necessary.

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The Relationship between Serum Lipids and Breast Cancer in Libya

Cited by 23 publications

References 22 publications

Alteration in Serum Lipid Profile Levels in Iraqi Women With Breast Cancer Before and After Chemotherapy

Alteration in Serum Lipid Profile Levels in Iraqi Women With Breast Cancer Before and After Chemotherapy

Evaluation of Serum Lipids and C-peptide among Breast Cancer Patients with Chemotherapy

Hormonal contraception increases risk of breast tumor based on clinical breast examination among adult women

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