The Relationship Between Serum Thiol Levels and Thiol/Disulfide Homeostasis with Head Trauma in Children

Giden, Ramazan; Gökdemir, Mehmet Tahir; Erel, Özcan; Büyükaslan, Hasan; Karabağ, Hamza

doi:10.7754/clin.lab.2017.170816

Cited by 15 publications

(14 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…72 fIGURE 1. miRNA expression in the most common cardiovascular diseases (CVDs). 56,[58][59][60][61][62][63][64][65][66] Moreover, numerous studies demonstrated that the activity of NF-κB has important implications on the he- in CVDs. From a molecular point of view, in the activation of TLR4 intervenes the myeloid differentiation factor 81 (MyD88), which is responsible of the connection between Toll/Interleukin-1 (Toll/IL-1) receptor (TIR) and TLR4.…”

Section: Mirnas and Acute Myocardial Infarctionmentioning

confidence: 99%

See 1 more Smart Citation

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

View full text Add to dashboard Cite

Worldwide, cardiovascular diseases (CVDs) represent one of the main causes of morbidity and mortality, and acute coronary syndromes are responsible for a large number of sudden cardiac deaths. One of the main challenges that still exist in this area is represented by the early detection and targeted monitoring of the pathophysiology involved in CVDs. During the last couple of years, researchers have highlighted the importance of molecular and epigenetic mechanisms involved in the initiation and augmentation of CVDs, culminating in their most severe form represented by acute myocardial infarction. One of the most studied molecular factors involved in this type of pathology is represented by nuclear transcription factor kappa B (NF-κB), as well as the involvement of microRNAs (miRNAs). It has been suggested that miRNAs can also be involved in the complex process of atheromatous plaque vulnerabilization that leads to an acute cardiac event. In this review paper, we describe the most important molecular mechanisms involved in the pathogenesis of CVDs and atheromatous plaque progression and vulnerabilization, which include molecular mechanisms dependent on NF-κB. For this paper, we used international databases (PubMed and Scopus). The keywords used for the search were “miRNAs biomarkers”, “miRNAs in cardiovascular disease”, “NF-κB in cardiovascular disease”, “molecular mechanism in cardiovascular disease”, and “myocardial NF-κB mechanisms”. Numerous molecular reactions that have NF-κB as a trigger are involved in the pathogenesis of CVDs. Moreover, miRNAs play an important role in initiating and aggravating certain segments of CVDs. Therefore, miRNAs can be used as biomarkers for early evaluation of CVDs. Furthermore, in the future, miRNAs could be used as a targeted molecular therapy in order to block certain mechanisms responsible for inducing CVDs and leading to acute cardiovascular events.

show abstract

Section: Mirnas and Acute Myocardial Infarctionmentioning

confidence: 99%

“…shows the most important changes in miRNA expression in the most common cardiovascular diseases 56,[58][59][60][61][62][63][64][65][66]. Nf-κB, INfLAmmATION, AND ATHEROSCLEROSISAnother important factor involved in the molecular mechanisms that lay at the basis of cardiovascular dis-eases is represented by nuclear factor kappa B (NF-κB) 15.…”

mentioning

confidence: 99%

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Buzaș

Rogobete

Popovici

et al. 2018

Journal of Cardiovascular Emergencies

View full text Add to dashboard Cite

show abstract

“…Following after withdrawn brain CTs, the risk of malignancies occurence associated with ionizing radiation in children increases (17). Exposure to ionizing radiation during CT scans has been shown to increase the risk of brain tumor and leukemia per mGy in children by 0.016 and 0.033, respectively (18). Also in another study which was made, radiation exposure after CT extractions in children creates a higher risk of cancer compared to adults (19).…”

Section: Discussionmentioning

confidence: 98%

Prognostic Value of Leukocytosis in Pediatric Head Trauma

Şahin¹,

Kayabaş²,

Aras³

2020

jmbas

View full text Add to dashboard Cite

Introduction: The most common cause of the morbidity and mortality in the childhood period age group is head traumas. In emergency departments computed tomography (CT) for diagnostic purposes is used more frequently in head traumas that are occurred in pediatric patients than in adults. Different protocols have been defined for brain CT in children with head trauma, clinical evaluations come to the fore in these protocols; however, there is no biomarker. Objective: Our aim in this study is to investigate the relationship between age, gender, trauma etiology, presence of symptoms at the time of admission, Glasgow Coma Scale (GCS), brain CT findings and blood WBC levels at admission. Method: 305 pediatric patients [between 0 and 18 years old] who applied to the emergency department of Kafkas University Medical Faculty Hospital between 2016 and 2019 after head trauma were included in the study. The data of these patients were analyzed retrospectively from the hospital records. Age, gender, head trauma etiology, GCS scores at the time of presentation, their symptoms, their brain CT findings and blood WBC levels were examined. Chi-square test was performed between patients with and without leukocytosis and independent variables. Results: After applying exclusion factors, the data of 173 patients who underwent CT in the emergency room after head trauma and whose blood tests were studied were examined. When patients were analyzed according to gender, 111 (64.2%) were male and 62 (35.8%) were found to be female. In terms of age, it was seen that those between the ages of 0 and 2 were 54 (31.2%), and those between the ages of 2- and 18 were 119 (68.8%). Among the etiological causes of traumas, the most frequent (n = 113) 65.3% falls were seen. The number of patients with symptoms was 57 (32.9%). Patients with GCS 14 ≥ constituted 69.4% of the total patients (n = 120). There was a pathological finding in 19.0% of the brain CT' s (n = 33) taken. Leukocytosis was detected in 17.3% of the patients [n = 30]. Conclusion: As a result of this study, it was found statistically significant that the blood WBC levels were higher in children who had head trauma, whose GCS was 13 ≤ at the time of application, who had symptoms and who had pathology in brain CT compared to other groups.

show abstract

“…In recent years, some biomarkers (lymphocyte, hemoglobin, hemotocrit, S100B, lactate, thiol) have been thought to assist in determining the prognosis in childhood head traumas and studies have been conducted associated with this [9,10,11]. In our study, the relationship between age, gender, trauma etiology, presence of symptoms at the time of admission, GCS, brain CT ndings and blood WBC levels at the time of application in cases of head trauma between the ages of 0-18, who were admitted to the emergency department in Turkey's Kars province were examined.…”

Section: Introductionmentioning

confidence: 99%

Prognostic Value Of Leukocytosis In Pediatric Head Trauma

Şahin

Kayabaş

Aras

2020

Preprint

View full text Add to dashboard Cite

Purpose Our aim in this study is to investigate the relationship between age, gender, trauma etiology, presence of symptoms at the time of admission, Glasgow Coma Scale (GCS), brain CT findings and blood WBC levels at admission. Methods 305 pediatric patients [between 0 and 18 years old] who applied to the emergency department of Kafkas University Medical Faculty Hospital between 2016 and 2019 after head trauma were included in the study. The data of these patients were analyzed retrospectively from the hospital records. Age, gender, head trauma etiology, GCS scores at the time of presentation, their symptoms, their brain CT findings and blood WBC levels were examined. Chi-square test was performed between patients with and without leukocytosis and independent variables. Results After applying exclusion factors, the data of 173 patients who underwent CT in the emergency room after head trauma and whose blood tests were studied were examined. When patients were analyzed according to gender, 111 (64.2%) were male and 62 (35.8%) were found to be female. In terms of age, it was seen that those between the ages of 0 and 2 were 54 (31.2%), and those between the ages of 2- and 18 were 119 (68.8%). Among the etiological causes of traumas, the most frequent (n = 113) 65.3% falls were seen. The number of patients with symptoms was 57 (32.9%). Patients with GCS 14 ≥ constituted 69.4% of the total patients (n = 120). There was a pathological finding in 19.0% of the brain CT' s (n = 33) taken. Leukocytosis was detected in 17.3% of the patients [n = 30]. Conclusion As a result of this study, it was found statistically significant that the blood WBC levels were higher in children who had head trauma, whose GCS was 13 ≤ at the time of application, who had symptoms and who had pathology in brain CT compared to other groups.

show abstract

The Relationship Between Serum Thiol Levels and Thiol/Disulfide Homeostasis with Head Trauma in Children

Abstract: Analysis of serum thiol levels and SH/SS homeostasis might be useful in order to determine the head trauma in pediatric patients.

Cited by 15 publications

References 0 publications

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Nuclear Transcription Factor Kappa B (NF-кB) and Molecular Damage Mechanisms in Acute Cardiovascular Diseases. A Review

Prognostic Value of Leukocytosis in Pediatric Head Trauma

Prognostic Value Of Leukocytosis In Pediatric Head Trauma

Contact Info

Product

Resources

About