The relationship between serum uric acid and lipid profile in Bangladeshi adults

Abstract

Background Although the link between elevated uric acid and metabolic syndrome has been reported in some studies; the relationship of serum uric acid (SUA) with lipid profile has not well studied or little is known so far. This study was conducted to assess the relationship between SUA and lipid profile among the general adults in Bangladesh. Methods In total, 280 blood samples were collected from general adult participants (male, n = 150 and female, n = 130) and analyzed for serum lipid profile (TC, TG, HDL and LDL) and SUA levels. The study subjects were divided by quartiles based on SUA levels (Q1: ≤225 μmol/L, Q2: 226–285 μmol/L, Q3: 286–340 μmol/L and Q4: > 340 μmol/L). Linear regression modeling was used to evaluate the relationship between SUA and lipid levels. Results The prevalence of hyperuricemia was 9.2% in males and 10.4% in females. The mean level of SUA was significantly higher in male (317 ± 90 μmol/L) than in the female (255 ± 65 μmol/L) subjects ( p < 0.001). An increasing trend for elevated lipid profile was observed in both gender with increasing levels of SUA in the quartiles ( p < 0.05). In regression analysis, a significant positive correlation was found between SUA and TG, TC and LDL ( p < 0.01) while an inverse correlation was observed between SUA and HDL ( p < 0.01). After adjusting for potential confounders, lipid profile was linearly associated with SUA levels ( p < 0.01 for trend). Conclusions Present study showed a significant positive relationship for SUA with TG, TC and LDL levels, and an inverse relationship for SUA with HDL. Early prevention of hyperuricemia and dyslipidemia may be helpful to reduce the incidence of associated cardiovascular diseases.

Association between dyslipidemia and serum uric acid levels in Korean adults: Korea National Health and Nutrition Examination Survey 2016-2017

“…In the present study, individual dyslipidemia components showed a statistically significant correlation with hyperuricemia even after adjusting for multiple laboratory & clinical confounders. Similar observations have been made in three previous cross-sectional studies [5,8]. In the study by Peng et al, the serum LDL-C levels, triglycerides, total cholesterol, apolipoprotein-B levels, ratio of triglycerides to HDL-C and ratio of apolipoprotein-B to apolipoprotein-A1 were significantly associated with serum uric acid levels, whereas serum HDL-C levels were inversely associated [5].…”

“…Although the risk factors for metabolic syndrome and cardiovascular disease are being thoroughly studied, only a few studies to date have linked dyslipidemia to serum uric acid, including those investigated with the adult population of Bangladeshi [8], India [9], Italy [10], China [11], and USA [5]. However, despite the high prevalence (11.4%) of hyperuricemia in Korean population [12], information is lacking on the association of dyslipidemia with serum uric acid within the community.…”

Prevalence of elevated liver enzymes and its association with type 2 diabetes: A cross‐sectional study in Bangladeshi adults

“…Trained medical personnel and graduate‐level students performed the anthropometric measurements according to the standard procedure described elsewhere . Individual's body weight and height were measured to calculate the body mass index (BMI), which was calculated as weight in kilogram divided by height in metres squared.…”

The comparison of dyslipidemia and serum uric acid in patients with gout and asymptomatic hyperuricemia: a cross-sectional study

“…For example, hypertriglyceridemia is more frequently observed in gouty patients than non-gouty individuals [3]. Over the last two decades, not only in gout patients, the association of hyperuricemia with cardiovascular risk factors has also been testified following the demonstration in animal models [4] and human studies [3,5]. Hyperuricemia has been reported to be associated with increased lipid levels [6] and decreased fibrous volume, potentially leading to raised plaque fragility [7].…”