The relationship between skin aging and steady state ultraweak photon emission as an indicator of skin oxidative stress <i>in vivo</i>

Gabe, Yu; Osanai, Osamu; Takema, Y.

doi:10.1111/srt.12121

Cited by 12 publications

(9 citation statements)

References 30 publications

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“…Therefore, the applications of SPE for the detection of metabolic processes in biological system are widely used. Present studies have suggested that the biophoton emission is a meaningful indicator of physiological state in biological systems [ 8 – 16 , 16 – 20 , 51 – 53 ]. In this view, we measured the SPE and contents of specific active compounds of roots and flowers buds with different growth ages and varieties of several fresh Chinese herbal medicines in order to prove whether the growth ages and varieties of fresh herbs could affect their SPE intensity and whether there was a close relationship between the bioactive constituents of fresh herbs and their SPE intensities.…”

Section: Discussionmentioning

confidence: 99%

Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

Zhao

Pang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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Ultraweak photon emission emitted by all living organisms has been confirmed to be a noninvasive indicator for their physiological and pathological characteristics. In this study, we investigated the characteristics of spontaneous photon emission (SPE) and the contents of specific active compounds of roots and flowers buds of several fresh Chinese herbal medicines (natural medicines) with different growth ages and varieties. The results revealed that the contents of specific active compounds from same species herbs with different growth ages and varieties were significantly different, and this difference could be reflected by their SPE. Because the contents of specific bioactive constituents in Chinese herbs are closely related to their quality and curative effect, the SPE measurement technique may contribute to the quality control of Chinese herbal medicine in the future.

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Section: Discussionmentioning

confidence: 99%

Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

Zhao

Pang

et al. 2017

Evidence-Based Complementary and Alternative Medicine

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“…ROS can inappropriately activate signaling pathways, interfere with genome maintenance and affect apoptosis. Numerous studies have tested the effects of solar radiation and oxidative stress on the skin [ 29 , 83 , 84 , 85 ], and oxidative stress has been linked to age-related loss of skin elasticity [ 86 , 87 , 88 ], defective cellular signaling [ 68 ] and photoaging [ 89 , 90 ]. Because it triggers cellular damage pathways, oxidative stress activates cellular senescence which is thought to directly lead to photoaging [ 91 , 92 , 93 , 94 ].…”

Section: Oxidative Stress and Agingmentioning

confidence: 99%

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

2014

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Being the largest and most visible organ of the body and heavily influenced by environmental factors, skin is ideal to study long-term effects of aging. Throughout our lifetime, we accumulate damage generated by UV radiation. UV causes inflammation, immune changes, physical changes, impaired wound healing and DNA damage that promotes cellular senescence and carcinogenesis. Melanoma is the deadliest form of skin cancer and among the malignancies of highest increasing incidence over the last several decades. Melanoma incidence is directly related to age, with highest rates in individuals over the age of 55 years, making it a clear age-related disease. In this review, we will focus on UV-induced carcinogenesis and photo aging along with natural protective mechanisms that reduce amount of “realized” solar radiation dose and UV-induced injury. We will focus on the theoretical use of forskolin, a plant-derived pharmacologically active compound to protect the skin against UV injury and prevent aging symptoms by up-regulating melanin production. We will discuss its use as a topically-applied root-derived formulation of the Plectranthus barbatus (Coleus forskolii) plant that grows naturally in Asia and that has long been used in various Aryuvedic teas and therapeutic preparations.

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“…A variety of other damages, involved in apoptosis, inflammation, carcinogenesis, and photoaging, are indirectly induced by UVinduced oxidative stress (Kulms et al, 2002;Nishisgori, 2015;Synowiec et al, 2015). Numerous studies have reported that UV-induced reactive oxygen species trigger damage response pathways by oxidative DNA damages (Gabe et al, 2014;Naylor et al, 2011;Prunier et al, 2012).…”

Section: Introductionmentioning

confidence: 99%

A Protective Mechanism of Visible Red Light in Normal Human Dermal Fibroblasts: Enhancement of GADD45A-Mediated DNA Repair Activity

Kim

et al. 2017

Journal of Investigative Dermatology

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The phototherapeutic effects of visible red light on skin have been extensively investigated, but the underlying biological mechanisms remain poorly understood. We aimed to elucidate the protective mechanism of visible red light in terms of DNA repair of UV-induced oxidative damage in normal human dermal fibroblasts. The protective effect of visible red light on UV-induced DNA damage was identified by several assays in both two-dimensional and three-dimensional cell culture systems. With regard to the protective mechanism of visible red light, our data showed alterations in base excision repair mediated by growth arrest and DNA damage inducible, alpha (GADD45A). We also observed an enhancement of the physical activity of GADD45A and apurinic/apyrimidinic endonuclease 1 (APE1) by visible red light. Moreover, UV-induced DNA damages were diminished by visible red light in an APE1-dependent manner. On the basis of the decrease in GADD45A-APE1 interaction in the activating transcription factor-2 (ATF2)-knockdown system, we suggest a role for ATF2 modulation in GADD45A-mediated DNA repair upon visible red light exposure. Thus, the enhancement of GADD45A-mediated base excision repair modulated by ATF2 might be a potential protective mechanism of visible red light.

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The relationship between skin aging and steady state ultraweak photon emission as an indicator of skin oxidative stress in vivo

Abstract: These results suggest that steady state UPE reflects not only intrinsic skin aging and cutaneous color but also the current oxidative status independent of skin aging.

Cited by 12 publications

References 30 publications

Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

Application of Spontaneous Photon Emission in the Growth Ages and Varieties Screening of Fresh Chinese Herbal Medicines

Ultraviolet Radiation, Aging and the Skin: Prevention of Damage by Topical cAMP Manipulation

A Protective Mechanism of Visible Red Light in Normal Human Dermal Fibroblasts: Enhancement of GADD45A-Mediated DNA Repair Activity

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