The relationship between socioeconomic level, and the prevalence of masked hypertension and asymptomatic organ damage

Ateş, İhsan; Altay, Mustafa; Kaplan, Mustafa; Ozkayar, Nihal; Toprak, Güvenç; Alagüney, Mehmet Erdem; Özkara, Adem

doi:10.1530/endoabs.37.ep548

Cited by 3 publications

(6 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…We included 16 studies [4][5][6][7][8][9][10][11][12][13][14][15][16][17][18][19] in the meta-analysis; 10 studies had both treated and untreated patients [4,7,[9][10][11][12][13][14]17,19], four had untreated [5,6,15,18] and two had treated patients [8,16]. Moreover, of the 10 studies with mixed patients, it was possible to segregate untreated and treated patients in three studies [4,10,13].…”

Section: Epidemiology Prevalencesmentioning

confidence: 99%

Masked Hypertension: A Systematic Review

Thakkar

Pope

Anpalahan

2020

Heart, Lung and Circulation

View full text Add to dashboard Cite

Section: Epidemiology Prevalencesmentioning

confidence: 99%

Masked Hypertension: A Systematic Review

Thakkar

Pope

Anpalahan

2020

Heart, Lung and Circulation

View full text Add to dashboard Cite

“…Additionally, Ateş et al discovered in a different study that the mean 24 h SBP, LVMI, microalbuminuria level, and retinopathy stage all correlated favorably. In all the patients being treated for hypertension, the 24 h SBP was found to be a predictor of such indications of AOD as LVMI, CIMT, and microalbuminuria …”

Section: Discussionmentioning

confidence: 98%

“…Similar findings have been made by Ates et al, 26 who claim that factors such as sex, age, BMI, hypertension duration, mean 24 h SBP, and mean 24 h DBP can all independently predict an elevated risk of AOD. Additionally, Ateş et al 27 discovered in a different study that the mean 24 h SBP, LVMI, microalbuminuria level, and retinopathy stage all correlated favorably. In all the patients being treated for hypertension, the 24 h SBP was found to be a predictor of such indications of AOD as LVMI, CIMT, and microalbuminuria.…”

Section: Discussionmentioning

confidence: 98%

“…In all the patients being treated for hypertension, the 24 h SBP was found to be a predictor of such indications of AOD as LVMI, CIMT, and microalbuminuria. 27 The involvement of the Wnt/β-catenin pathway in numerous biological processes, such as embryogenic development, adult tissue homeostasis, and wound healing, has received a lot of attention recently. 28 According to our findings, patients had higher levels of β-catenin than controls.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

LncRNA-GAS5 and β-Catenin as Independent Predictors of Asymptomatic Organ Damage in Nondiabetic Hypertensive Patients

et al. 2023

View full text Add to dashboard Cite

Hypertension is a serious medical condition that can increase the risk of developing heart, brain, kidney, and other diseases. Many asymptomatic hypertension patients experience asymptomatic organ damage (AOD). The purpose of this study was to determine the roles of LncRNA-GAS5 and β-catenin in predicting AOD in hypertensive nondiabetic patients. This study included 256 subjects, 128 hypertension patients (75 of whom had AOD, and 53 of whom did not) and 128 healthy controls. qRT-PCR was used to assess LncRNA-GAS5, and ELISA was used to assess β-catenin. The LncRNA-GAS5 expression level was decreased in hypertensive patients compared to controls (p-value < 0.001). On the other hand, β-catenin levels showed higher levels in the patients in comparison with controls (p-value < 0.001). A 0.38-fold change in LncRNA-GAS5 expression predicted AOD with 86.6% sensitivity and 88.7% specificity. β-Catenin > 80.5 pg/mL predicted AOD with a sensitivity of 82.6% and specificity of 69.8%. LncRNA-GAS5 expression was a better diagnostic predictor of AOD than β-catenin. According to multivariate logistic regression analysis, decreased LncRNA-GAS5 expression independently increased the risk of AOD (adjusted odds ratio = 0.03 (95% CI: 0.01–0.1) (p < 0.001). Furthermore, elevated β-catenin levels may be an independent risk factor for AOD (adjusted odds ratio = 14.3 (95% confidence interval, 3.3–61.9) (p < 0.001). Collectively, in hypertensive patients, LncRNA GAS5 and β-catenin can distinguish patients with AOD from those who do not have AOD. LncRNA GAS5 and β-catenin can be used as independent predictors of AOD in hypertensive patients.

show abstract

“…After adjustment for baseline characteristics, OH was significantly associated with the riser type circadian rhythm (adjusted odds ratio 4.532, 95% CI: 2.579–7.966). The 24‐h ambulatory BP monitoring is a useful non‐invasive technique for evaluating patients with labile hypertension or episodes of hypotension, as it can reflect the patients’ BP fluctuations and circadian rhythms, and thus offers advantages over traditional office BP measurement. Elevated night‐time BP and non‐dipping profiles have been evaluated in several studies, and it has been shown that elevated night‐time BP, or inverted dippers, is associated with vascular damage, cardiovascular risk and mortality.…”

Section: Discussionmentioning

confidence: 99%

Blood pressure circadian rhythms and adverse outcomes in type 2 diabetes patients diagnosed with orthostatic hypotension

Chang

Hou

et al. 2017

J of Diabetes Invest

View full text Add to dashboard Cite

Aims/IntroductionPatients with diabetes frequently develop orthostatic hypotension (OH). The present study was designed to examine the relationship of blood pressure (BP) circadian rhythms and outcomes in diabetes with OH.Materials and MethodsIn the present study, 173 inpatients with type 2 diabetes were enrolled. Patients were divided into an OH group and a non‐OH group according to the BP changes detected in the supine and standing position. Then, 24‐h ambulatory BP was monitored. Patients were followed up for an average of 45 ± 10 months post‐discharge. Outcomes – death and major adverse cardiac and cerebrovascular events, including heart failure, myocardial infarction and stroke – were recorded.ResultsThere were 61 patients (35.26%) in the OH group and 112 patients (64.74%) in the non‐OH group. In the OH group, the night‐time systolic BP and night‐time diastolic BP were higher, the blood BP rhythms were predominantly of the riser type (67.21%). OH was as an independent marker of riser type circadian rhythm (adjusted odds ratio 4.532, 95% confidence interval 2.579–7.966). In the OH group, the incidence rates of mortality, and major adverse cardiac and cerebrovascular events were increased significantly compared with those in the non‐OH group (11.48 vs 2.68%, P = 0.014; 37.70 vs 8.93%, P < 0.01).ConclusionsIn patients who had type 2 diabetes diagnosed with OH, the BP circadian rhythm usually showed riser patterns, and they had increased rates of mortality, and major adverse cardiac and cerebrovascular events.

show abstract

The relationship between socioeconomic level, and the prevalence of masked hypertension and asymptomatic organ damage

Cited by 3 publications

References 0 publications

Masked Hypertension: A Systematic Review

Masked Hypertension: A Systematic Review

LncRNA-GAS5 and β-Catenin as Independent Predictors of Asymptomatic Organ Damage in Nondiabetic Hypertensive Patients

Blood pressure circadian rhythms and adverse outcomes in type 2 diabetes patients diagnosed with orthostatic hypotension

Contact Info

Product

Resources

About