The relationship between subclinical hypothyroidism and serum levels of uric acid and creatinine in children aged 2–14 years

Sayari, Saba; Molaei, Ziba; Torabi, Zohreh

doi:10.6065/apem.2018.23.1.38

Cited by 7 publications

(9 citation statements)

References 20 publications

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“…The significant (p < 0.05) decrease in TSH may suggest that oxidative stress might have occurred due to the intake of tartrazine and curcumin. Sayari et al (2018) reported heavy presence of ROS or free radicals on the follicular cells of the thyroid gland; whereas, T 3 and T 4 which are stored, could decrease TSH. The increase in T 3 Table 5.…”

Section: Thyroid Hormonesmentioning

confidence: 99%

“…The increased level of TSH cause hyper stimulation of the thyroid gland, thus resulting in high levels of T 3 and T 4 ; however, due to negative feedback mechanism, increased level of T 4 and T 3 stimulates reduced production of TSH from the pituitary (Sayari et al, 2018). Among female mice, ingestion of diets containing turmeric oleoresin (curcumin) was associated with an increased incidence of thyroid gland follicular cell hyperplasia (NTP, 1993); histopathological changes in thyroid gland have been recorded by Shakoor (2019) in the high tartrazine and curcumin treated groups.…”

Section: Thyroid Hormonesmentioning

confidence: 99%

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Impact of tartrazine and curcumin on mineral status, and thyroid and reproductive hormones disruption in vivo

Shakoor¹,

Ismail²,

Zia-ur-Rahman³

et al. 2022

IFRJ

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Endocrine disrupters (EDCs) are naturally occurring or man-made substances that either mimic or obstruct the functions of oestrogens and androgens, thyroid hormones, as well as microminerals in the body. The present work aimed to evaluate the effects of oral administration of tartrazine and curcumin, synthetic and natural dyes, respectively, on thyroid hormones (T3, T4, and TSH), female reproductive hormones (oestrogen, progesterone, LH, and FSH), and minerals (iron, copper, zinc, sodium, potassium, and chloride) in plasma, liver, and kidney of female rats after 15, 30, and 45 d of treatment. The rats were treated with admissible daily intake (ADI) and 10× ADI (9.6 and 96 mg/kg/body weight for tartrazine, 3.85 and 38.5 mg/kg/body weight for curcumin, respectively). Results showed significant changes in thyroid and female reproductive hormones, especially, in the tartrazine-treated groups as compared to the control. Low and high doses of tartrazine and curcumin significantly (p < 0.05) decreased iron, copper, and zinc concentrations in plasma, whereas, the concentrations of sodium and copper in liver and kidney increased. Both tartrazine and curcumin, at ADI and 10× ADI, resulted in lower LH levels after 30 and 45 d of treatment. After 30 d, low and high dose of tartrazine significantly decreased T4, oestrogen, and FSH levels; whereas, progesterone level increased. The results demonstrated that hormone secretion and mineral content in tissues are severely affected at ADI and higher concentrations of tartrazine and curcumin. These observations suggested that lower doses of these dyes might be a safer option for their usage in foods and pharmaceuticals.

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Section: Thyroid Hormonesmentioning

confidence: 99%

Section: Thyroid Hormonesmentioning

confidence: 99%

Impact of tartrazine and curcumin on mineral status, and thyroid and reproductive hormones disruption in vivo

Shakoor¹,

Ismail²,

Zia-ur-Rahman³

et al. 2022

IFRJ

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“…Both overtly hypothyroid and SHypo patients may have high serum urea and creatinine levels, and regular monitoring of renal function is suggested as the renal dysfunction in TD is often reversible [ 44 , 90 ]. Resolution of hypothyroidism is associated with significant reduction in serum creatinine levels [ 91 ].…”

Section: Pragmatic Thyrovigilancementioning

confidence: 99%

Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies

Kalra

Aggarwal²,

Khandelwal

2021

International Journal of Endocrinology

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Thyroid dysfunction (TD) is common in metabolic disorders such as diabetes mellitus (DM), cardiovascular disease (CVD), obesity, dyslipidemia, hyperuricemia, kidney and liver dysfunctions, and polycystic ovary syndrome (PCOS). Subclinical hypothyroidism (SHypo) worsens glycemic control in patients with DM, and these patients, especially those with Type-1DM, have higher prevalence of TD. Both TD and DM increase CVD risk. Even minor alteration in thyroid hormone (TH) levels can alter cardiovascular function. While hyperthyroidism increases systolic blood pressure and leads to high-output heart failure, hypothyroidism increases diastolic blood pressure and leads to low-output heart failure. Chronic subclinical hyperthyroidism (SHyper) and SHypo both increase the risk of hypertension, coronary artery disease (CAD) events, CAD deaths, and total deaths. SHyper alters cardiac morphology and function. SHypo causes dyslipidemia and endothelial dysfunction and increases the risk for weight gain and obesity. Overweight and obese patients often have hyperleptinemia, which increases the secretion of thyroid stimulating hormone (TSH) and induces TD. Dyslipidemia associated with TD can increase serum uric acid levels. Hyperuricemia promotes inflammation and may increase the risk for dyslipidemia, atherosclerosis, and CVD. TD increases the risk for developing chronic kidney disease. In nephrotic syndrome, proteinuria is associated with urinary loss of TH leading to TD. Some correlation between TD and severity of liver disease is also seen. TD and PCOS have common risk factors and pathophysiological abnormalities. Hypothyroidism must be excluded before diagnosing PCOS. Current guidelines do not strongly recommend thyroid screening in the presence of all metabolic disorders. However, pragmatic thyrovigilance is required. Clinicians must stay alert to signs and symptoms of TD, maintain high clinical suspicion, and investigate thoroughly. Drug-induced TD should be considered when TH levels do not match clinical findings or when patients are on medications that can alter thyroid function.

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“…In some of the studies, serum uric acid levels failed to show any significant elevation, especially in the pediatric patients with subclinical hypothyroidism. In one such study, Sayari et al 12 found that children with subclinical hypothyroidism did not have significantly different serum uric acid levels (p>0.05), although serum creatinine levels were significantly elevated, signifying a decline in the clearance of this substance.…”

Section: Discussionmentioning

confidence: 99%

Serum uric acid in patients with abnormal thyroid functions: a cross-sectional study

Bhattarai¹,

Manandhar²

2019

J Chitwan Med Coll

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Background: Hyperuricemia, a pathologic consequence of over-production or under-excretion of uric acid, is a common biochemical picture in thyroid dysfunctions. This study was designed to determine the serum uric acid levels and the prevalence rates of hyperuricemia in thyroid dysfunctions. Methods: A cross-sectional study was conducted at College of Medical Sciences and Teaching Hospital, Chitwan in which Serum uric acid concentrations of male and female participants, 30 years or older with the diagnosis of hypothyroidism or hyperthyroidism were estimated. Hyperuricemia was defined as uric acid levels >6.8mg/dL (males) and >6.0 mg/dL (females). Descriptive statistics using frequency with percentage and inferential statistics using parametric and non-parametric tests were used. Results: In the total 249 participants, the prevalence of hyperuricemia was 30.5% (32.9% in hyperthyroid and 26.1% in hypothyroid patients). Similarly, the mean serum uric acid levels in these patients was 5.46 ± 1.88mg/dL (5.60 ± 1.71 in hyperthyroid and 5.20 ± 2.13mg/dL in hypothyroid patients). Hyperuricemia was present in 32.6% of the female and 27.6% of the male patients. Likewise, the rate was 28.1% in 30–40 years old, 30.0% in 40–50 years old, 30.9% in 50–60 years old, and 32.8% in >=60 years old participants. There was no significant association between hyperuricemia and age or gender in overall participants and in participants of either of the two groups of thyroid dysfunctions (p>0.05). Conclusions: The reported prevalence of hyperuricemia in thyroid dysfunctions justifies the need of further studies to understand the causal relationship between thyroid status and serum uric acid.

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The relationship between subclinical hypothyroidism and serum levels of uric acid and creatinine in children aged 2–14 years

Cited by 7 publications

References 20 publications

Impact of tartrazine and curcumin on mineral status, and thyroid and reproductive hormones disruption in vivo

Impact of tartrazine and curcumin on mineral status, and thyroid and reproductive hormones disruption in vivo

Thyroid Dysfunction and Dysmetabolic Syndrome: The Need for Enhanced Thyrovigilance Strategies

Serum uric acid in patients with abnormal thyroid functions: a cross-sectional study

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