The relationship between synovial fluid <scp>VEGF</scp> and serum leptin with ultrasonographic findings in knee osteoarthritis

Kim, Hae-Rim; Lee, Jung-Hwa; Kim, Kyoung-Woon; Kim, Bomi; Lee, Sang‐Heon

doi:10.1111/1756-185x.12486

Cited by 20 publications

(20 citation statements)

References 35 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In agreement with our study Kim et al [23], they found that the level of VEGF was higher in patients with KL grade 4 than those with KL grade 2 and there was positive correlation between synovial VEGF and KL grades. In addition, Lee et al [27] who studied 34 OA patients, they found that the synovial fluid level of VEGF was higher in patients with KL grade 4 than those of KL grade 2 and synovial VEGF level was positively correlated with KL scores, however they differ from our study as they found no significant difference in plasma VEGF level among OA patients with different KL grades.…”

Section: Discussionsupporting

confidence: 93%

“…Rübenhagen et al [26] detected significant correlation between the synovial fluid level of VEGF and the age of patients. On the contrary Kim et al [23] found negative correlation between synovial fluid VEGF and total WOMAC, WOMAC stiffness and WOMAC function. Also there was negative correlation between synovial VEGF and total WOMAC, WOMAC pain and WOMAC stiffness.…”

Section: Discussionmentioning

confidence: 86%

See 1 more Smart Citation

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Abdel-Magied¹,

AbuOmar²,

Higazi³

et al. 2019

Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

Aim of the work: Detection of serum and synovial fluid level of Vascular Endothelial Growth Factor (VEGF) in patients with knee osteoarthritis (OA) and to determine its relation to radiological severity and function status. Patients and methods: Thirty OA patients and thirty controls were included. Function status was assessed using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Knee pain evaluated using the Visual Analogue Scale (VAS). Serum and synovial fluid level of VEGF were measured. Kellgren-Lawrence grading scale (KL) used to assess radiological severity. Results: The mean of patients' age was 50.33 ± 5.3 years (20 females and 10 males) with disease duration of 7.03 ± 2.12 years. Mean synovial fluid VEGF of OA patients was 964.1 ± 396.72, mean serum VEGF of OA patients was 219.1 ± 96.95. No difference between serum VEGF of patients and control groups (p=0.787). Significant positive correlation between serum and synovial VEGF in OA patients (r=0.58, p=0.001). Significant positive correlation between the synovial fluid VEGF and patients' age, disease duration, inactivity stiffness, ESR, VAS, WOMAC and KL grade scale (p‹0.0001,p=0.029,p‹0.0001,p‹0.0001,p=0.00 3,p‹0.0001,p‹0.0001). Significant positive correlation between serum VEGF and patients' age, inactivity stiffness, WOMAC, ESR and KL grade scale (p‹0.0001, p=0.005, p=0.001, p=0.001,p=0.010). Synovial fluid VEGF was the significant predictors for determining the function status (p‹0.0001); while for determining severity; synovial fluid VEGF, patients' age and VAS were significant predictors (p‹0.0001,p=0.001 and p=0.029 respectively). Conclusion: Serum and synovial fluid VEGF correlated with the clinical features, functional status and radiological features of Knee OA. Synovial VEGF can predict both functional impact and radiological severity in patients with knee OA.

show abstract

Section: Discussionsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 86%

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Abdel-Magied¹,

AbuOmar²,

Higazi³

et al. 2019

Int. J. Clin. Rheumatol

View full text Add to dashboard Cite

show abstract

“…VEGF is a secreted mitogen associated with angiogenesis that has been reported to regulate the vascular invasion of the hypertrophic cartilage in OA; one isoform of which, VEGF-A, promotes subsequent cartilage vascularization (32,33). A meta-analysis revealed that VEGF is upregulated in patients with OA (7) and that it contributes to the severity of knee OA (34,35). Intravenous and intra-articular administration of the anti-VEGF antibody bevacizumab facilitates articular cartilage repair and attenuates the severity of OA (36,37).…”

Section: Discussionmentioning

confidence: 99%

Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of rapamycin C1 signaling pathway

Ouyang

Jiang

Fang

et al. 2017

Molecular Medicine Reports

View full text Add to dashboard Cite

Osteoarthritis (OA) is the most common disease of the joints, and is characterized by the breakdown of cartilage and degradation of the extracellular matrix. OA causes a high level of patient suffering and incurs large societal costs; however, the current strategies for treating OA are restricted due to limited understanding of the underlying molecular and cellular mechanisms. In the present study, the beneficial effects of isoimperatorin (Iso) were investigated using an experimental mouse model of OA, and its mechanism of action on primary chondrocytes was elucidated. Destabilization of the medial meniscus was performed on 8‑week‑old male mice to induce OA in the knees. Iso (500 mg/g/day) was intragastrically administered for 4 weeks. Degeneration of articular cartilage was assessed by histology using the Osteoarthritis Research Society International scoring system. The expression of matrix metalloproteinase (MMP)13, Runt‑related transcription factor (Runx)2, type X collagen (Col X) and vascular endothelial growth factor (VEGF) in the knee joints was examined by immunohistochemistry. In vitro, murine primary chondrocytes were treated with various concentrations of Iso, followed by 10 ng/ml interleukin‑1. The mRNA expression levels of MMP13, Runx2, Col X and VEGF were determined by reverse transcription‑quantitative polymerase chain reaction. The levels of autophagy and mammalian target of rapamycin (mTOR) signaling were determined by western blotting. Iso significantly ameliorated the severity of articular cartilage degradation in mice with experimental OA. The expression levels of MMP13, Runx2, Col X and VEGF were reduced in Iso‑treated mice. In murine primary chondrocytes, Iso also reduced MMP13, Runx2, Col X and VEGF expression, and activated autophagy by downregulating the mTOR complex 1 (mTORC1) signaling pathway. Therefore, the results of the present study demonstrated that Iso ameliorates OA‑induced pathological alterations by delaying chondrocyte deterioration, activating autophagy and inhibiting mTORC1, which suggests that Iso may have therapeutic potential for attenuating articular cartilage degradation and treating OA.

show abstract

“…Angiogenesis is an extremely important process in normal development and tissue homeostasis and repair, besides contributes directly also to various forms of pathology, such as tumor development and metastasis, psoriasis, rheumatoid arthritis, and wet macular degeneration [37]. One of the most important proangiogenic mediators is vascular endothelial growth factor (VEGF), responsible for stimulating new blood vessels formation, tissue proliferation, migration, differentiation, and survival, which contribute to the angiogenesis process, in addition to influencing the repair and wound closure and granulation tissue formation [38]. The VEGF family has several members, and one of its members such as VEGF-A begins the process of wound healing promoting biological events linked to angiogenesis and migration of endothelial cells [39].…”

Section: Growth Factorsmentioning

confidence: 99%

Regulatory Mechanisms and Chemical Signaling of Mediators Involved in the Inflammatory Phase of Cutaneous Wound Healing

Beserra¹,

Gushiken²,

Hussni³

et al. 2019

Wound Healing - Current Perspectives

View full text Add to dashboard Cite

Wound healing is a highly complex biological process composed of three overlapping phases: inflammatory, proliferative, and remodeling. The acute inflammatory response has being an integral role in tissue healing and fundamental for the homeostasis and reestablishment. This phase depends on the interaction of cytokines, growth factors, chemokines, and chemical mediators from cells to perform regulatory events and complex interactions of the extracellular matrix, extracellular molecules, soluble mediators, various resident cells such as fibroblasts and keratinocytes, and infiltrated leukocyte subtypes that act to restore or replace the integrity of the skin. If this well-orchestrated response becomes deregulated, the wound can become chronic or progressively fibrotic, with both outcomes impairing tissue function, which can ultimately lead to organ failure and death. In this chapter, we will review the pathway in the skin healing cascade, relating the major chemical inflammatory mediators, cellular and molecular, as well as demonstrating the local and systemic factors that interfere in healing and disorders associated with tissue repair deficiency in chronic inflammations, burns and hypertrophy.

show abstract

The relationship between synovial fluid VEGF and serum leptin with ultrasonographic findings in knee osteoarthritis

Abstract: Synovial fluid VEGF level was correlated with radiographic grading, ultrasonographic findings and functional statues in knee osteoarthritis, and serum leptin level also correlated with the ultrasonographic findings and functional status of knee osteoarthritis.

Cited by 20 publications

References 35 publications

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Synovial fluid level of vascular endothelial growth factor (VEGF) can predict functional status and radiological severity in patients with knee osteoarthritis (OA)

Isoimperatorin ameliorates osteoarthritis by downregulating the mammalian target of rapamycin C1 signaling pathway

Regulatory Mechanisms and Chemical Signaling of Mediators Involved in the Inflammatory Phase of Cutaneous Wound Healing

Contact Info

Product

Resources

About