The relationship between the acute changes in the systemic inflammatory response, lipid soluble antioxidant vitamins and lipid peroxidation following elective knee arthroplasty

Gray, Andrew; McMillan, Donald C.; Wilson, Chris; Williamson, Cathy; O’Reilly, Denis St. J.; Talwar, Dinesh

doi:10.1016/j.clnu.2005.02.008

Cited by 29 publications

(29 citation statements)

References 11 publications

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“…30,31 In the present study there were no significant differences in cholesterol and triglyeride concentrations between the groups and therefore neither carotenoid nor malondialdehyde concentrations were corrected for these lipids.…”

Section: Resultsmentioning

confidence: 91%

“…[15][16][17] Both the tumour growth and progression and the systemic inflammatory response have the potential to produce free radicals and thus increase oxidative stress. Indeed, both the presence and progression of cancer [18][19][20][21] and the systemic inflammatory response [22][23][24][25] are associated with lower carotenoid concentrations. However, to date the majority of studies have only included relatively small number of cancer patients ( 30).…”

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confidence: 99%

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Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer

Leung

Crozier

Talwar

et al. 2008

Intl Journal of Cancer

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Both the tumour growth and progression and the systemic inflammatory response have the potential to increase oxidative stress. We therefore examined the relationship between lipid-soluble antioxidant vitamins, lipid peroxidation, the systemic inflammatory response and survival in patients with primary operable (n 5 53) and advanced inoperable (n 5 53) colorectal cancer. Compared with those patients with primary operable colorectal cancer, patients with unresectable liver disease had significantly lower median concentrations of a-tocopherol (p < 0.001), lutein (p < 0.001), lycopene (p < 0.001), a-carotene (p < 0.01) and b-carotene (p < 0.001) and higher malondialdehyde concentrations. An elevated systemic inflammatory response (Glasgow prognostic score, mGPS) was associated with a greater proportion of females (p < 0.05) and more advanced tumour stage (p < 0.05), lower circulating levels of retinol (p < 0.01), lutein (p < 0.01), lycopene (p < 0.01) and a-(p < 0.01) and b-carotene but not MDA (p 5 0.633). In the liver metastases group 41 patients died of their cancer and a further 1 patient died of intercurrent disease on follow-up. On univariate survival analysis, mGPS (p < 0.01), retinol (p < 0.001), atocopherol (p < 0.05) and a-carotene (p < 0.05) were associated significantly with cancer-specific survival. On multivariate survival analysis of these significant variables, only mGPS (p < 0.01) and retinol (p < 0.001) were independently associated with cancer-specific survival. The results of the present study showed that the systemic inflammatory response was associated with a reduction of lipid-soluble antioxidant vitamins, whereas advanced tumour stage was associated with increased lipid peroxidation in patients with colorectal cancer. Of the antioxidant vitamins measured, only retinol was independently associated with cancer-specific survival. ' 2008 Wiley-Liss, Inc.Key words: colorectal cancer; vitamin A; vitamin E; carotenoids; malonyldialdehyde; TNM stage; Glasgow prognostic score; survival Colorectal cancer remains the second commonest cause of cancer deaths in Western Europe and North America. Each year in the United Kingdom, there are 35,000 new cases and 16,000 deaths attributable to the disease.1 Overall survival is poor; even in those patients who undergo potentially curative resection, more than one-third die within 5 years. It is increasingly recognised that variations in outcome in cancer patients are not solely determined by the characteristics of the tumour but also by host-immune response factors. [3][4][5] It is now accepted that the host systemic inflammatory response can be assessed by examining the changes in the circulating concentrations of acute-phase proteins, such as an elevated concentration of C-reactive protein and a low concentrations of albumin 6 and that these have prognostic values in patients with cancer. 7,8 Recently, the combination of C-reactive protein and albumin, known as the Glasgow prognostic score (GPS), has been validated as a prognostic factor in patients with color...

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Section: Resultsmentioning

confidence: 91%

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confidence: 99%

Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer

Leung

Crozier

Talwar

et al. 2008

Intl Journal of Cancer

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“…The lack of evidence that raising of 25(OH)D concentration can modify the occurrence or clinical course of diseases is not causal and may explain why low vitamin D status is reported in a wide range of disorders. In fact, a fluctuation in vitamin D levels has been described after an inflammatory insult, such as surgical stress (Louw et al 1992;Gray et al 2005). In patients who underwent cardiac surgery, a transitory decline in 1-25-hydroxyvitamin D is observed together with a significant increase in inflammatory markers including IL-6.…”

Section: Discussionmentioning

confidence: 99%

“…On the contrary, the systemic inflammatory response, occurring after an inflammatory insult, could determine lower 25(OH)D concentration (Louw et al 1992;Gray et al 2005). Although a potential relationship between 25(OH)D and inflammation has been hypothesized, there is inconclusive evidence about the anti-inflammatory role of vitamin D, especially in the elderly.…”

Section: Introductionmentioning

confidence: 93%

Relationship between vitamin D and inflammatory markers in older individuals

Vita

Lauretani

Bauer

et al. 2014

AGE

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In older persons, vitamin D insufficiency and a subclinical chronic inflammatory status frequently coexist. Vitamin D has immune-modulatory and in vitro anti-inflammatory properties. However, there is inconclusive evidence about the anti-inflammatory role of vitamin D in older subjects. Thus, we investigated the hypothesis of an inverse relationship between 25-hydroxyvitamin D (25(OH)D) and inflammatory markers in a population-based study of older individuals. After excluding participants with high-sensitivity C-reactive protein (hsCRP)≥10 mg/dl and those who were on chronic anti-inflammatory treatment, we evaluated 867 older adults ≥65 years from the InCHIANTI Study. Participants had complete data on serum concentrations of 25(OH)D, hsCRP, tumor necrosis factor (TNF)-α, soluble TNF-α receptors 1 and 2, interleukin (IL)-1β, IL-1 receptor antagonist, IL-10, IL-18, IL-6, and soluble IL-6 receptors (sIL6r and sgp130). Two general linear models were fit (model 1-adjusted for age, sex, and parathyroid hormone (PTH); model 2-including covariates of model 1 plus dietary and smoking habits, physical activity, ADL disability, season, osteoporosis, depressive status, and comorbidities). The mean age was 75.1±17.1 years±SD. In model 1, AGE (2014) log(25OH-D) was significantly and inversely associated with log(IL-6) (β±SE=−0.11±0.03, p=<0.0001) and log (hsCRP) (β±SE=−0.04±0.02, p=0.04) and positively associated with log(sIL6r) (β±SE=0.11±0.04, p=0.003) but not with other inflammatory markers. In model 2, log (25OH-D) remained negatively associated with log (IL-6) (β±SE=−0.10±0.03, p=0.0001) and positively associated with log(sIL6r) (β±SE=0.11± 0.03, p = 0.004) but not with log(hsCRP) (β ±SE= −0.01±0.03, p=0.07). 25(OH)D is independently and inversely associated with IL-6 and positively with sIL6r, suggesting a potential anti-inflammatory role for vitamin D in older individuals.

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“…We also examined the relationship between phylloquinone and triglyceride concentrations in plasma to establish a phylloquinone population reference interval expressed as a ratio to the triglyceride concentration. Because systemic inflammatory response is associated with a decrease in plasma triglyceride concentrations (28 ) and may lower vitamin concentrations independently of tissue stores (28,29 ), we also examined the effect of acute systemic inflammatory response on phylloquinone concentrations in plasma.…”

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confidence: 99%

HPLC Method for Plasma Vitamin K1: Effect of Plasma Triglyceride and Acute-Phase Response on Circulating Concentrations

et al. 2007

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Background:The plasma concentration of vitamin K 1 (phylloquinone) is the most reliable index for assessing vitamin K status. Our aim was to analytically validate an HPLC method for quantifying phylloquinone in plasma and to examine the effect of plasma triglyceride concentration on the phylloquinone reference interval. We also examined the effect of acute-phase response on phylloquinone concentration in plasma. Methods: Phylloquinone was extracted from fasting plasma samples by deproteinization and C18 solidphase extraction, separated by reversed-phase HPLC, and detected fluorometrically after postcolumn reduction with a platinum catalyst. We synthesized a novel internal calibrator, docosyl naphthoate. Results: The recovery of phylloquinone was >90%. Between-run imprecision was 8.7%-9.0%, and withinrun imprecision was 3.8%-7.0%. The linearity was up to 44.8 nmol/L, limit of detection 0.08 nmol/L, and limit of quantification 0.14 nmol/L. The correlation between plasma phylloquinone and triglyceride concentrations was r ‫؍‬ 0.7 in the reference population. The 95% reference interval for the phylloquinone:triglyceride ratio was 0.20 to 2.20 nmol/mmol. Plasma concentrations of C-reactive protein were significantly increased, whereas triglyceride and phylloquinone but not the phylloquinone:triglyceride ratio were transiently decreased >50% after surgery.

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The relationship between the acute changes in the systemic inflammatory response, lipid soluble antioxidant vitamins and lipid peroxidation following elective knee arthroplasty

Cited by 29 publications

References 11 publications

Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer

Vitamin antioxidants, lipid peroxidation, tumour stage, the systemic inflammatory response and survival in patients with colorectal cancer

Relationship between vitamin D and inflammatory markers in older individuals

HPLC Method for Plasma Vitamin K1: Effect of Plasma Triglyceride and Acute-Phase Response on Circulating Concentrations

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