The relationship between the cornea and the optic disc

Abstract

Objective To evaluate the structural relationship between the cornea and the optic disc in normal subjects. Methods This hospital-based observational study included 205 eyes from 205 individuals who were diagnosed as normal at our glaucoma clinic. The subjects underwent an eye examination, optic disc imaging with optic disc photography, optical coherence tomography, IOL master, specular microscopy, and ultrasound corneal pachymetry. Results In univariate regression models (Pearson's correlation coefficient), the cup-to-disc (CD) ratio showed a negative correlation with corneal curvature (r ¼ À0.315, Po0.001) and central corneal thickness (r ¼ À0.206, P ¼ 0.005), and a positive correlation with white-to-white diameter (horizontal limbus to limbus distance, r ¼ 0.215, P ¼ 0.003). In multiple linear regression models with CD ratio as the dependant parameter, the CD ratio was still significantly associated with corneal curvature (b ¼ À0.205, P ¼ 0.011) and white-to-white diameter (b ¼ 0.207, P ¼ 0.010). The central corneal thickness failed to show statistical significance, but did show a negative correlation with borderline significance (b ¼ À0.133, P ¼ 0.075). Conclusions Eyes with a large CD ratio have large and flat corneas; this may suggest that there is a structural relationship between the cornea and the optic disc. These results can be helpful in analysing the anatomical relationship between the cornea and the optic disc.

Correlation between central corneal thickness and visual field defects, cup to disc ratio and retinal nerve fiber layer thickness in primary open angle glaucoma patients

“…We found negative and statistically significant correlation between CCT and CDR, demonstrating thicker corneas to be having less CDR. This is consistent with findings by Kim JM et al who found negative and significant correlation between CCT and CDR, though after multiple regression analysis the correlation appeared to be not statistically significant 8. Wangsupadilok and associates also found negative and significant relation between CCT and CDR 11.…”

Associations between Optic Cup-to-disc Ratio and Systemic Factors in the Healthy Korean Population

“…However, in this study, we observed no significant differences among patients with myopia, emmetropia, and hyperopia, perhaps because we excluded subjects with glaucoma. The Singapore Malay Eye Study [ 6 ] also showed similar results, while Kim et al [ 27 ] noted that CDR was not correlated with axial length in normal subjects. Jonas et al [ 28 ] and Wang et al [ 29 ] reported that optic disc size was correlated with myopic refractive error.…”

The Association Between Ocular Rigidity and Neuroretinal Damage in Glaucoma

“…1,24,25,[30][31][32][33]45 Various studies have found associations between these parameters and optic nerve parameters, including rim area. 27,31,34,[46][47][48][49][50][51] More specifically, Jonas et al 51 found a significant correlation between CCT and the neuroretinal rim area (r = 0.13, P < 0.001) as measured from stereo optic disc slides in a cohort regrouping normal, OAG, and OHT eyes. Park et al 49 showed that low CCT, CH, and CRF were associated with a smaller rim area (r = 0.256, P = 0.012; r = 0.347, P = 0.001; and r = 0.227, P = 0.027, respectively), as measured using the HRT (Heidelberg Retina Tomograph), in eyes with normotensive glaucoma (NTG) but not in normal eyes.…”