The relationship between the degree
of malnutrition and changes in selected
parameters of the immune response
in critically ill patients

Stelmasiak, Marta; Bałan, Barbara J.; Mikaszewska-Sokolewicz, Małgorzata; Niewiński, Grzegorz; Kosałka, Katarzyna; Szczepanowska, Ewelina; Słotwiński, Robert

doi:10.5114/ceji.2021.105248

Cited by 3 publications

(3 citation statements)

References 54 publications

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“…Furthermore, studies from Kenya, Ghana, and Turkey showed a significantly higher proinflammatory response, including elevated serum IL-6 levels, when comparing children with protein-energy deficiency to healthy counterparts (29)(30)(31) . Such increase in proinflammatory cytokines, including IL-6, was also described in malnourished patients in the intensive care unit, which was associated with higher mortality risk (22) . Of note, Manary et al (15) described higher serum cytokines, including IL-6, but, marasmic toddlers had lower amounts of acute phase proteins than well-nourished children who had infections.…”

Section: Discussionmentioning

confidence: 71%

“…SAM is a significant contributor to children's compromised immune systems, resulting in abnormalities related to opsonization, complement system and phagocytosis, chemotactic activity of neutrophils and monocytes, and antigen-presenting cell function. As part of its detrimental effects on the immune system, SAM may reduce the amount of amino acids and other cofactors needed for the production of cytokines and other acute phase reactants, which might impede the acute phase inflammatory response, including cytokines (13,15,22) . However, previous studies have reported inconsistent findings concerns children with SAM's capacity to produce an appropriate acute phase immune response (9,10,18,20)…”

Section: Discussionmentioning

confidence: 99%

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Serum Levels of Interleukins 6 And 8 In Malnourished Children with Acute Diarrhea: A Case-Control Study

2024

The Egyptian Journal of Hospital Medicine

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Background: Acute gastroenteritis continues to be a prevalent global health issue among children. The release of interleukin-6 (IL-6) and interleukin-8 (IL-8) from the gastrointestinal tract's epithelial cells is essential for protection against mucosal infections because it triggers the body's inflammatory reactions to infectious pathogens both locally and systemically. Objectives: To investigate serum levels of IL-6 and IL-8 in malnourished children with acute diarrhea. Patients and Methods: A case-control study that included three groups of 30 children each: children with severe acute malnutrition (SAM) and acute diarrhea (SAM-AD), well-nourished children with acute diarrhea (AD), and healthy controls (HC). Participants underwent clinical evaluation and routine laboratory investigations. Serum levels of IL-6 and IL-8 were measured within 72 hours of diarrheal onset using Luminex  Human Premixed Multi-Analyte kit. Results: Serum level of IL-6 in the SAM-AD group (median 1.0 [IQR 1-4.3] pg/ml) was comparable to the HC group (2.2 [1-4.6] pg/ml) but significantly lower than the AD group (12 [3.9-175.6] pg/ml). The SAM-AD group had significantly lower pg/ml) than the AD (612 [84.8-800] pg/ml) and HC (157.5 [23.8-298.7] pg/ml) group. IL-6, IL-8, and CRP showed significantly strong correlation with one another (r > 0.67; p <0.001). The presence of fever was significantly associated with higher levels of IL-6, IL-8, and CRP. Conclusion Our study found significantly lower serum levels of IL-6, IL-8, and CRP in malnourished children with acute diarrhea compared to well-nourished children with acute diarrhea, which indicates that malnutrition may impede the acute phase inflammatory response during acute diarrhea.

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Section: Discussionmentioning

confidence: 71%

Section: Discussionmentioning

confidence: 99%

Serum Levels of Interleukins 6 And 8 In Malnourished Children with Acute Diarrhea: A Case-Control Study

2024

The Egyptian Journal of Hospital Medicine

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“…The prevalence of malnutrition in patients is high, and this direct correlation has been well established in the literature (Fabretti et al, 2015;Niseteo et al, 2020;Arnau-Barrés et al, 2021). Malnourished organisms are immunosuppressed because of the lack of nutrients for the synthesis of cytokines, complement, and gamma globulins, and for the promotion of mitosis and phagocytosis by leukocytes (Stelmasiak et al, 2021). This results in atrophy of the organs related to the immune system, an increase in the frequency and severity of infections, and worsening of prognosis (Lombardi, 2019;Stelmasiak et al, 2021), as noted in G2 and G3.…”

Section: Disease Severity Markersmentioning

confidence: 99%

Avaliação nutricional e laboratorial como preditores do tempo de hospitalização, gravidade da doença de base e mortalidade em cães

Fabretti,

Siqueira,

Gomes

et al. 2023

Sem. Ci. Agr.

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Prognóstico é definido na medicina, como uma predição baseada no diagnóstico do paciente e nas possibilidades terapêuticas, acerca da duração da enfermidade, gravidade da doença e taxa de óbito. Os índices de prognóstico utilizados em medicina humana ou mesmo os poucos padronizados para medicina veterinária não são muito difundidos ou aplicados na clínica de pequenos animais. Dessa forma, esta pesquisa objetivou identificar variáveis de uso comum na rotina clínica que possam ser úteis como marcadoras de prognóstico, se correlacionando, especificamente como o tempo de internamento (TI), gravidade de doença e mortalidade. Para tal, foram avaliados 246 cães da rotina de um hospital veterinário escola do sul do Brasil, estudados em relação ao estado nutricional (EN) (por anamnese, exame físico e laboratorial), exames hematológicos e diversos parâmetros bioquímicos séricos. Foram calculadas as frequências, médias e desvios-padrões das variáveis, análises de correlação e análises comparativas (Kruskal-Wallis em α = 5%). Foram considerados marcadores relevantes de gravidade de doença em cães: presença de desnutrição, incluindo histórico de hiporexia, anorexia, escore de condição corporal (ECC) ≤3 e escore de massa muscular (EMM≤2); baixos valores de transferrina (TF), da capacidade total de ligação ao ferro (CTLF) e anemia; além de valores elevados de índice de saturação da transferrina (IST), lactato e da relação PCR/albumina. Nos animais sem doenças sistêmicas ou com doenças sistêmicas discretas a moderadas, os indicadores de elevado TI foram: baixos valores de albumina, relação Proteína-C-Reativa (PCR)/Albumina e hiporexia. Nos animais com doenças sistêmicas críticas, os indicadores de baixo TI (secundários a alta mortalidade) foram: baixos valores de índice de massa corporal (IMC) e hemoglobina (HB). Os indicadores de mortalidade em cães doentes foram: hipoalbuminemia e elevada concentração de ureia. Conclui-se que a constatação dessas alterações, especialmente quando ocorrem simultaneamente, embasa a determinação do prognóstico em cães de uma população hospitalar, de maneira objetiva, prática e acessível.

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From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity

Li,

2024

Ageing Research Reviews

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The relationship between the degree of malnutrition and changes in selected parameters of the immune response in critically ill patients

Cited by 3 publications

References 54 publications

Serum Levels of Interleukins 6 And 8 In Malnourished Children with Acute Diarrhea: A Case-Control Study

Serum Levels of Interleukins 6 And 8 In Malnourished Children with Acute Diarrhea: A Case-Control Study

Avaliação nutricional e laboratorial como preditores do tempo de hospitalização, gravidade da doença de base e mortalidade em cães

From biological aging to functional decline: Insights into chronic inflammation and intrinsic capacity

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