The relationship between the erythrocyte sedimentation rate (ESR) and plasma proteins in clinical materials and models

Talstad, Ingebrigt; Haugen, Hans Fredrik

doi:10.3109/00365517909108829

Cited by 26 publications

(20 citation statements)

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“…These changes, however, would be canceled in the presence of an in crease in the dielectric coefficient of plasma («, equation 2) which is dependent on the concentration and charge of the glycopro teins. Indeed, the levels of some glycopro teins have been reported to be increased in plasma in many pathological conditions characterized by high ESR [2,5,14,15] and can also be deduced from our findings of elevated concentrations of sialic acid. In this connection, the importance of this resi due has been supported by the observation that treatment of serum with neuraminidase resulted in the lack of aggregation of eryth rocytes [11].…”

Section: Discussionsupporting

confidence: 57%

“…This, in our opinion, is not surprising since fibrinogen, which has been reported to play a role in ESR [4], has not been studied in this work and the various conditions with elevated ESR are associated with various types of glycoproteins [6,14] in which the sialic acid content is known to differ [5]. In addition, the contribution of many other factors as plasma viscosity, the number, size and deformability of erythrocytes as well as the possible involvement of pathology of the liver, which is held responsible for the bio synthesis of plasma glycoproteins, in the heterogenous group of patients included in this work has to be taken into consideration.…”

Section: Discussionmentioning

confidence: 90%

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Red Blood Cell Membrane and Serum Sialic Acid in Relation to Erythrocyte Sedimentation Rate

et al. 1980

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Sialic acid was determined in red blood cell (RBC) membrane and in serum, and correlated to erythrocyte sedimentation rate (ESR). For this purpose blood samples were obtained from 57 patients, regardless of their pathological condition, and divided into groups according to the ESR. 15 blood samples obtained from healthy individuals whose ESR was lower than 20 mm/h served as controls. Sialic acid was released from RBC membranes obtained by hemolysis, and from serum glycoproteins precipitated with ethanol by treatment with 0.1 TV HC1 at 80 °C for 1 h. The results showed the sialic acid contents of both membranes and serum to be higher in most of the groups with elevated ESR, as compared to the control group, although no quantitative correlation was noticed. Statistical evaluation showed highly significant differences between the group of pathological samples as a whole and the control group in the sialic acid content of both RBC membranes and sera.

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Section: Discussionsupporting

confidence: 57%

Section: Discussionmentioning

confidence: 90%

Red Blood Cell Membrane and Serum Sialic Acid in Relation to Erythrocyte Sedimentation Rate

et al. 1980

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“…The acceleration of sedimentation with increases in the concentration of fibrinogen and globulin has been documented by several authors (Gilligan and Ernstene 1934, Chien ef al 1971, Talstad and Haugen 1979, Bull 1981, Crawford et a1 1987. It is the elevation in these protein concentrations with inflammation or disease that results in the ESR test being such a widely used monitor of health.…”

Section: Discussionmentioning

confidence: 76%

“…Talstad and Haugen (1979) noted that an increase in albumin concentration inhibited the ESR. In terms of the 60 min ESR, the conventional measure, these data support that earlier finding.…”

Section: Discussionmentioning

confidence: 99%

Optimization of conditions for selective dissociation of trifluorobromomethane molecules in carbon isotope separation

Avatkov¹,

Laptev²,

Ryabov³

et al. 1985

Sov. J. Quantum Electron.

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Precise measurements have been made of the rate of sedimentation of whole blood in which the concentrations of red blood cells and the plasma proteins have been systematically varied. The contribution of each factor to the sedimentation process is expressed in terms of three parameters that describe the sedimentation c w e : the set-up time, and the slopes of the fint and second phases of settling. This analysis affords delination between the onset and the degree of aggregation of the red blood cells as contributors to the usual ESR value. the height of plasma in a 200 nm blood column after 60 min. In t e m of the 60 min ESR value, an increase in the haematocrit or albumin concentration inhibits sedimentation, the latter only slightly. whereas an increase in the concentration of globulin or fibrinogen accelerates sedimentation. with fibrinogen showing the more marked effect.

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“…In multiple myeloma of the IgG and IgA subtypes, significant correlations have been found between ESR and the monoclonal proteins and between the ESR and percentageof plasma cells in bone marrow. 23 Alexandrakis et al 24 suggest that ESR is an independent prognostic factor for survival in patients with MM. Patients with earlier-stage disease may also show elevated levels of this acute phase protein, as evident by the raised ESR in our MGUS/SMM cohort.…”

Section: Discussionmentioning

confidence: 99%

Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia)

et al. 2016

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Hypothesis. Prior studies on patients with early B-cell lymphoid malignancies suggest that early intervention with curcumin may lead to delay in progressive disease and prolonged survival. These patients are characterized by increased susceptibility to infections. Rice bran arabinoxylan (Ribraxx) has been shown to have immunostimulatory, anti-inflammatory, and proapoptotic effects. We postulated that addition of Ribraxx to curcumin therapy may be of benefit. Study design. Monoclonal gammopathy of undetermined significance (MGUS)/smoldering multiple myeloma (SMM) or stage 0/1 chronic lymphocytic leukemia (CLL) patients who had been on oral curcumin therapy for a period of 6 months or more were administered both curcumin (as Curcuforte) and Ribraxx. Methods. Ten MGUS/SMM patients and 10 patients with stage 0/1 CLL were administered 6 g of curcumin and 2 g Ribraxx daily. Blood samples were collected at baseline and at 2-month intervals for a period of 6 months, and various markers were monitored. MGUS/SMM patients included full blood count (FBC); paraprotein; free light chains/ratio; C-reactive protein (CRP)and erythrocyte sedimentation rate (ESR); B2 microglobulin and immunological markers. Markers monitored for stage 0/1 CLL were FBC, CRP and ESR, and immunological markers. Results. Of 10 MGUS/ SMM patients,5 (50%) were neutropenic at baseline, and the Curcuforte/Ribraxx combination therapy showed an increased neutrophil count, varying between 10% and 90% among 8 of the 10 (80%) MGUS/SMM patients. An additional benefit of the combination therapy was the potent effect in reducing the raised ESR in 4 (44%) of the MGUS/SMM patients. Conclusion. Addition of Ribraxx to curcumin therapy may be of benefit to patients with early-stage B-cell lymphoid malignancies. Keywords curcumin, rice bran arabinoxylan, monoclonal gammopathy of undetermined significance (MGUS), smoldering myeloma (SMM), stage 0/1 chronic lymphocytic leukemia (CLL), early stage B-cell lymphoid malignancies

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The relationship between the erythrocyte sedimentation rate (ESR) and plasma proteins in clinical materials and models

Cited by 26 publications

References 0 publications

Red Blood Cell Membrane and Serum Sialic Acid in Relation to Erythrocyte Sedimentation Rate

Red Blood Cell Membrane and Serum Sialic Acid in Relation to Erythrocyte Sedimentation Rate

Optimization of conditions for selective dissociation of trifluorobromomethane molecules in carbon isotope separation

Addition of Rice Bran Arabinoxylan to Curcumin Therapy May Be of Benefit to Patients With Early-Stage B-Cell Lymphoid Malignancies (Monoclonal Gammopathy of Undetermined Significance, Smoldering Multiple Myeloma, or Stage 0/1 Chronic Lymphocytic Leukemia)

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